Effects of Chinese Medicine on Symptoms, Syndrome Evolution, and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-Up after Hospital Discharge: A Prospective Cohort and Nested Case-Control Study

Li LI; Chun-yan GOU; Xue-mei LI; Wen-yan SONG; Xiao-jun WANG; Hong-ying LI; Hong-yan LI; Xiu-hui LI

doi:10.1007/s11655-021-3328-3

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Effects of Chinese Medicine on Symptoms, Syndrome Evolution, and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-Up after Hospital Discharge: A Prospective Cohort and Nested Case-Control Study

Original Article | Updated：2021-08-16

- Effects of Chinese Medicine on Symptoms, Syndrome Evolution, and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-Up after Hospital Discharge: A Prospective Cohort and Nested Case-Control Study
- Effects of Chinese Medicine on Symptoms, Syndrome Evolution, and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-Up after Hospital Discharge: A Prospective Cohort and Nested Case-Control Study
- Chinese Journal of Integrative Medicine 2021年27卷第4期页码：245-251
- Affiliations：
  
  1.Integrated Traditional Chinese and Western Medicine Center, Beijing Youan Hospital, Capital Medical University, Beijing(100069), China
  2.Chronic Disease Management Center, Beijing Youan Hospital, Capital Medical University, Beijing(100069), China
  3.Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing (100069), China
- Author bio：
  
  Correspondence to: Prof. LI Xiu-hui, E-mail: lixiuhui@sohu.com
- Funds：
  
  the National Key Research and Development Project;National Science and Technology Major Project;Project of Beijing Administration of Traditional Chinese Medicine
- DOI：10.1007/s11655-021-3328-3
  中图分类号：
- 纸质出版日期：2021-04-01，
  
  网络出版日期：2021-02-03，
  
  录用日期：2020-10-19
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Li LI, Chun-yan GOU, Xue-mei LI, 等. Effects of Chinese Medicine on Symptoms, Syndrome Evolution, and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-Up after Hospital Discharge: A Prospective Cohort and Nested Case-Control Study[J]. Chinese Journal of Integrative Medicine, 2021,27(4):245-251.

Li LI, Chun-yan GOU, Xue-mei LI, et al. Effects of Chinese Medicine on Symptoms, Syndrome Evolution, and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-Up after Hospital Discharge: A Prospective Cohort and Nested Case-Control Study[J]. Chinese Journal of Integrative Medicine, 2021,27(4):245-251.
Li LI, Chun-yan GOU, Xue-mei LI, 等. Effects of Chinese Medicine on Symptoms, Syndrome Evolution, and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-Up after Hospital Discharge: A Prospective Cohort and Nested Case-Control Study[J]. Chinese Journal of Integrative Medicine, 2021,27(4):245-251. DOI： 10.1007/s11655-021-3328-3.

Li LI, Chun-yan GOU, Xue-mei LI, et al. Effects of Chinese Medicine on Symptoms, Syndrome Evolution, and Lung Inflammation Absorption in COVID-19 Convalescent Patients during 84-Day Follow-Up after Hospital Discharge: A Prospective Cohort and Nested Case-Control Study[J]. Chinese Journal of Integrative Medicine, 2021,27(4):245-251. DOI： 10.1007/s11655-021-3328-3.

摘要

Abstract

Objective:

To observe the changes of symptoms

Chinese medicine (CM) syndrome

and lung inflammation absorption during convalescence in patients with coronavirus disease 2019 (COVID-19) who had not totally recovered after hospital discharge and whether CM could promote the improvement process.

Methods:

This study was designed as a prospective cohort and nested case-control study. A total of 96 eligible patients with COVID-19 in convalescence were enrolled from Beijing Youan Hospital and Beijing Huimin Hospital and followed up from the hospital discharged day. Patients were divided into the CM (64 cases) and the control groups (32 cases) based on the treatment with or without CM and followed up at 14

and 84 days after discharge. In the CM group

patients received the 28-day CM treatment according to two types of CM syndrome. Improvements in clinical symptoms

CM syndrome

and absorption of lung inflammation were observed.

Results:

All the 96 patients completed the 84-day follow-up from January 21 to March 28

2020. By the 84th day of follow-up

respiratory symptoms were less than 5%. There was no significant difference in the improvement rates of symptoms

including fatigue

sputum

cough

dry throat

thirst

and upset

between the two groups (

0.05). Totally 82 patients (85.42%) showed complete lung inflammation absorption at the 84-day follow-up. On day 14

the CM group had a significantly higher absorption rate than the control group (

0.05) and the relative risk of absorption for CM vs. control group was 3.029 (95% confidence interval: 1.026–8.940). The proportions of CM syndrome types changed with time prolonging: the proportion of the pathogen residue syndrome gradually decreased

and the proportion of both qi and yin deficiency syndrome gradually increased.

Conclusions:

Patients with COVID-19 in convalescence had symptoms and lung inflammation after hospital discharge and recovered with time prolonging. CM could improve lung inflammation for early recovery. The types of CM syndrome can be transformed with time prolonging. (Registration No. ChiCTR2000029430)

关键词

Keywords

COVID-19convalescent patientChinese medicinesyndrome evolutionpneumonia absorption

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