没食子酸：一种潜在的抗癌药物

Yuan JIANG; Jin PEI; Yan ZHENG; Yu-jing MIAO; Bao-zhong DUAN; Lin-fang HUANG

doi:10.1007/s11655-021-3345-2

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没食子酸：一种潜在的抗癌药物

Review | Updated：2022-06-27

- 没食子酸：一种潜在的抗癌药物
- Gallic Acid: A Potential Anti-Cancer Agent
- Chinese Journal of Integrative Medicine 2022年28卷第7期页码：661-671
- Affiliations：
  
  1.Key Laboratory of Chinese Medicine Resources Conservation,State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (100193), China
  2.State Key Laboratory of Southwestern Chinese Medicine Resources,Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu (611137), China
  3.College of Pharmaceutical Science, Dali University, Dali, Yunnan Province (671000), China
- Author bio：
  
  Prof. HUANG Lin-fang, E-mail: lfhuang@implad.ac.cn
- Funds：
  
  the National Natural Science Foundation of China(U1812403-1-1);National Science and Technology Fundamental Resources Investigation Program of China(2018FY100701)
- DOI：10.1007/s11655-021-3345-2
  中图分类号：
- 纸质出版日期：2022-07-01，
  
  网络出版日期：2021-11-10，
  
  录用日期：2021-09-17
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Yuan JIANG, Jin PEI, Yan ZHENG, 等. 没食子酸：一种潜在的抗癌药物[J]. Chinese Journal of Integrative Medicine, 2022,28(7):661-671.

Yuan JIANG, Jin PEI, Yan ZHENG, et al. Gallic Acid: A Potential Anti-Cancer Agent[J]. Chinese Journal of Integrative Medicine, 2022,28(7):661-671.
Yuan JIANG, Jin PEI, Yan ZHENG, 等. 没食子酸：一种潜在的抗癌药物[J]. Chinese Journal of Integrative Medicine, 2022,28(7):661-671. DOI： 10.1007/s11655-021-3345-2.

Yuan JIANG, Jin PEI, Yan ZHENG, et al. Gallic Acid: A Potential Anti-Cancer Agent[J]. Chinese Journal of Integrative Medicine, 2022,28(7):661-671. DOI： 10.1007/s11655-021-3345-2.

摘要

癌症是世界范围内最具毁灭性的疾病之一

尽管进行了广泛的研究

但目前尚无确切的癌症治疗方法. 主要挑战包括与传统化疗相关的限制因素

主要是耐药性、低应答率和不良副作用. 因此

对新型抗癌药物的需求量很大

这些药物对癌症预防和治疗既有效又安全. 没食子酸 (GA) 是一种天然的植物酚类化合物

可以调节多种治疗特性

包括抗炎、减肥和抗癌活性. 最近

GA通过多种生物途径发挥抗癌活性

包括迁移、转移、凋亡、细胞周期阻滞、血管生成和癌基因表达. 本文从两个方面进行了综述

一是GA对不同类型癌症的抗癌潜力及其潜在的分子机制

二是GA在癌症和肿瘤研究中的文献计量学分析. 结果表明

肺癌、前列腺癌、胃癌和结肠癌可能成为进一步研究的热点. 总的来说

这篇综述提供了证据表明GA是一种有希望的新型、有效和安全的抗癌候选药物

用于治疗癌症.

Abstract

Cancer is one of the most devastating diseases worldwide and definitive therapeutics for treating cancer are not yet available despite extensive research efforts. The key challenges include limiting factors connected with traditional chemotherapeutics

primarily drug resistance

low response rates

and adverse side-effects. Therefore

there is a high demand for novel anti-cancer drugs that are both potent and safe for cancer prevention and treatment. Gallic acid (GA)

a natural botanic phenolic compound

can mediate various therapeutic properties that are involved in anti-inflammation

anti-obesity

and anti-cancer activities. More recently

GA has been shown to exert anti-cancer activities via several biological pathways that include migration

metastasis

apoptosis

cell cycle arrest

angiogenesis

and oncogene expression. This review discusses two aspects

one is the anti-cancer potential of GA against different types of cancer and the underlying molecular mechanisms

the other is the bibliometric analysis of GA in cancer and tumor research. The results indicated that lung cancer

prostate cancer

stomach cancer

and colon adenocarcinoma may become a hot topic in further research. Overall

this review provides evidence that GA represents a promising novel

potent

and safe anti-cancer drug candidate for treating cancer.

关键词

Keywords

gallic acidcancertumorbibliometricapplication

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