针刺辅助体外受精胚胎移植的疗效及安全性：概况性评价

Wen-cui XIU; Wei-juan GANG; Rui-min JIAO; Lan-jun SHI; Ji-wei YANG; Xiang-hong JING; Xiao-shuang SHI

doi:10.1007/s11655-021-3459-6

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针刺辅助体外受精胚胎移植的疗效及安全性：概况性评价

Review | Updated：2022-06-27

- 针刺辅助体外受精胚胎移植的疗效及安全性：概况性评价
- Effect of Acupuncture on Outcomes of in vitro Fertilisation: A Scoping Review
- Chinese Journal of Integrative Medicine 2022年28卷第5期页码：472-480
- Affiliations：
  
  Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing (100700), China
- Author bio：
  
  Prof. SHI Xiao-shuang, E-mail:massxs@163.com
- Funds：
  
  Innovation Fund of China Academy of Chinese Medical Sciences(CI2021A03503);"The Belt and Road"TCM Cooperation Project of China Academy of Chinese Medical Sciences(GH201901);the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ13-024-9)
- DOI：10.1007/s11655-021-3459-6
  中图分类号：
- 纸质出版日期：2022-05-01，
  
  网络出版日期：2021-12-12，
  
  录用日期：2021-08-09
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Wen-cui XIU, Wei-juan GANG, Rui-min JIAO, 等. 针刺辅助体外受精胚胎移植的疗效及安全性：概况性评价[J]. Chinese Journal of Integrative Medicine, 2022,28(5):472-480.

Wen-cui XIU, Wei-juan GANG, Rui-min JIAO, et al. Effect of Acupuncture on Outcomes of in vitro Fertilisation: A Scoping Review[J]. Chinese Journal of Integrative Medicine, 2022,28(5):472-480.
Wen-cui XIU, Wei-juan GANG, Rui-min JIAO, 等. 针刺辅助体外受精胚胎移植的疗效及安全性：概况性评价[J]. Chinese Journal of Integrative Medicine, 2022,28(5):472-480. DOI： 10.1007/s11655-021-3459-6.

Wen-cui XIU, Wei-juan GANG, Rui-min JIAO, et al. Effect of Acupuncture on Outcomes of in vitro Fertilisation: A Scoping Review[J]. Chinese Journal of Integrative Medicine, 2022,28(5):472-480. DOI： 10.1007/s11655-021-3459-6.

摘要

目的:

系统梳理和总结分析针刺对体外受精 (IVF) 疗效和安全性的现有临床研究证据.

方法:

计算机检索8个中英文数据库

包括PubMed、EMBASE、Cochrane系统评价数据库、Cochrane随机对照试验数据库、中国知网、万方数据库、中国生物医学数据库以及维普数据库

并手动检索所有纳入文献的相关参考文献列表作为补充. 两位研究者独立完成了文献筛选、数据提取和系统综述方法学质量的评估. 纳入研究的一般信息及其具体特征以定性描述为主

采用气泡图来直观地显示针灸对IVF结果的总体影响.

结果:

共纳入82篇研究

包括64篇原始研究和18篇系统综述. 大多数研究都采用了经皮穴位电刺激、电针和手针

对照不针刺、假针刺或安慰剂针刺. 有63篇 (98.4%) 原始研究报告了临床妊娠率

其中在34篇 (54.0%) 研究中发现了针刺对临床妊娠率的积极作用. 只有18篇 (28.1%) 原始研究报告了活产率

其中10篇 (55.6%) 显示了积极的效果. 此外

在系统综述中

显示针刺可以增加临床妊娠事件和活产事件的研究分别为8篇和2篇

但这些系统综述的方法学质量都不高.

结论:

现有研究倾向于支持在IVF-ET过程中进行针刺可以提高临床妊娠率. 但由于报告活产率的原始研究数量较少

这为判断针刺是否能够增加活产事件带来了一定的难度. 此外

此外

大多数系统综述的方法学质量都为极低

这可能在一定程度上限制了证据的推广和传播. 因此

我们鼓励应实施更严格的研究设计以获得更为可靠的结果. 与此同时

应着重提高研究方法学质量

促进高透明和标准化的报告.

Abstract

Objectives:

To identify

examine and summarize the available evidence on the effectiveness and safety of acupuncture for

in vitro

fertilisation (IVF) outcomes.

Methods:

Eight electronic databases

including PubMed

EMBASE

Cochrane Database of Systematic Review

Cochrane Central Register of Controlled Trials

China National Knowledge Infrastructure

Wanfang Database

Chinese Biomedical Database and VIP Database

were searched

supplemented by manual searches. Two researchers independently conducted the literature screening

data extraction

and methodological quality assessments. A narrative description was provided to show the general information and specific characteristics of the included studies. A bubble plot was used to visually display the overall effects of acupuncture on IVF outcomes.

Results:

Eighty-two studies were identified

including 64 primary studies and 18 systematic reviews. Transcutaneous electrical acupoint stimulation

electric acupuncture and manual acupuncture were applied in most studies and compared with no acupuncture

sham acupuncture and placebo acupuncture control groups. Sixty-three (98.4%) primary studies reported clinical pregnancy rate

and positive effects of acupuncture were found in 34 studies (54.0%). Live birth rate was reported in only 18 (28.1%) primary studies

of which 10 (55.6%) showed positive results. In addition

only 8 and 2 systematic reviews showed that acupuncture could increase clinical pregnancy events and live birth events

respectively. However

none of these reviews was of high methodological quality.

Conclusions:

Available evidence suggests that acupuncture therapy could improve clinical pregnancy rates. However

whether acupuncture could increase live birth events was difficult to determine based on the few studies that have reported this outcome indicator. Furthermore

the methodological quality of most systematic reviews was assessed as critically low or low. Studies with a rigorous design and standardized implementation should be performed to refine the available evidence.

关键词

Keywords

acupuncturein vitro fertilisationclinical pregnancy ratelive birth ratescoping review

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