Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women:A Randomized Controlled Trial*

Hao-xu DONG; Qing WANG; Zhi WANG; Xiao-ke WU; Ling CHENG; Zhong-ming ZHOU; Li YANG; Ping YI; Dong-mei HUANG

doi:10.1007/s11655-021-3482-z

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Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women:A Randomized Controlled Trial*

Original Article | Updated：2021-10-18

- Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women:A Randomized Controlled Trial*
- Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women:A Randomized Controlled Trial*
- Chinese Journal of Integrative Medicine 2021年27卷第10期页码：737-743
- Affiliations：
  
  1.Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan (430030), China
  2.Department of Traditional Chinese Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan (430030),China
  3.Department of Rehabilitation Center of Wuhan Puren Hospital, Affiliated Hospital of Wuhan University of Science and Technology, Wuhan (430081), China
  4.Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin (150040), China
  5.Department of Acupuncture and Moxibustion, East Hospital,Tongji University, Shanghai (200120), China
  6.Department of Obstetrics and Gynecology, Hubei University of Traditional Chinese Medicine, Wuhan (430060), China
- Author bio：
  
  Prof. HUANG Dong-mei, E-mail:hdmjcr@163.com
- Funds：
  
  the National Natural Science Foundation of China(81573787;81803913)
- DOI：10.1007/s11655-021-3482-z
  中图分类号：
- 纸质出版日期：2021-10-01，
  
  网络出版日期：2021-07-28，
  
  录用日期：2019-11-11
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Hao-xu DONG, Qing WANG, Zhi WANG, 等. Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women:A Randomized Controlled Trial*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):737-743.

Hao-xu DONG, Qing WANG, Zhi WANG, et al. Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women:A Randomized Controlled Trial*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):737-743.
Hao-xu DONG, Qing WANG, Zhi WANG, 等. Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women:A Randomized Controlled Trial*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):737-743. DOI： 10.1007/s11655-021-3482-z.

Hao-xu DONG, Qing WANG, Zhi WANG, et al. Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women:A Randomized Controlled Trial*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):737-743. DOI： 10.1007/s11655-021-3482-z.

摘要

Abstract

Objective:

To explore the effect of electro-acupuncture (EA) on glucose and lipid metabolism in unmarried patients with polycystic ovary syndrome (PCOS).

Methods:

Fifty-four PCOS patients were equally randomized into true acupuncture group and sham acupuncture group (control) for totally 16 weeks of treatment by random method with a computerized randomization program. Patients in true acupuncture group accepted traditional acupuncture methods with EA and two sets of acupoint groups were used alternatively. The first set consisted of Zhongji (CV 3)

Qihai (CV 6)

Guilai (ST 29)

Sanyinjiao (SP 6)

Yinlingquan (SP 9)

Hegu (LI4) and Baihui (GV 20)

and the second set consisted of Tianshu (ST 25)

ST 29

CV 3

CV 6

SP 6

Taichong (LR 3)

Neiguan (PC) 6 and GV 20. Patients in the sham acupuncture group accepted shallow acupuncture methods through EA without electricity at 4 non-meridian points in each shoulder and upper arm. Outcome measures included body mass index (BMI)

waist-hip-ratio (WHR)

oral glucose tolerance test (OGTT)

insulin release test

glucose and lipid metabolism indicators such as total cholesterol (TC)

triglycerides

high-density lipoprotein cholesterol (HDL-C)

low-density lipoprotein cholesterol

adiponectin

leptin

visfatin

resistin

and interleukin (IL-6).

Results:

Twenty-six subjects in the true acupuncture group and 20 subjects in the sham group completed the clinical trial. After 16 weeks of treatment

no significant difference in the outcome measures were observed between the two groups (

0.05). However

as compared with baseline data

a reduction in weight

BMI

hipline

WHR

fasting glucose

homeostatic model assessment of insulin sensitivity

visfatin and HDL-C

and an increase in resistin and IL-6 were observed in the true acupuncture group (

0.05). In addition

a reduction in visfatin and an increase in TC were also observed in the sham group (

0.05).

Conclusions:

Acupuncture may have a beneficial effect in the treatment of PCOS by improving glucose and lipid metabolism. Moreover

the sham acupuncture may be not completely ineffective. Sham acupuncture may improve some of the aspects of the glucose and lipid metabolism of PCOS patients through a placebo effect. (Registration Nos. ChiCTR-TRC-12002529 and NCT01812161)

关键词

Keywords

electro-acupunctureglucose and lipid metabolismsham acupuncturevisfatinpolycystic ovary syndrome

references

Ding T, Baio G, Hardiman PJ, Petersen I, Sammon C.Diagnosis and management of polycystic ovary syndrome in the UK (2004–2014): a retrospective cohort study. BMJ Open 2016;6:e012461.

Joham AE, Teede HJ, Ranasinha S, Zoungas S, Boyle J. Prevalence of infertility and use of fertility treatment in women with polycystic ovary syndrome: data from a large community-based cohort study. J Womens Health (Larchmt)2015;24:299-307.

Jiao J, Fang Y, Wang T, Wang Z, Zhou M, Wang X.Epidemiologic investigation of polycystic ovarian syndrome(PCOS) in Han ethnic women of reproductive age in Liaoning Province, China. Clin Exp Obstet Gynecol 2014;41:304-309.

Kim JJ, Choi YM. Dyslipidemia in women with polycystic ovary syndrome. Obstet Gynecol Sci 2013;56:137-142.

Jamilian M, Razavi M, Fakhrie Kashan Z, Ghandi Y,Bagherian T, Asemi Z. Metabolic response to selenium supplementation in women with polycystic ovary syndrome:a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf) 2015;82:885-891.

Majid H, Masood Q, Khan AH. Homeostatic model assessment for insulin resistance (HOMA-IR): a better marker for evaluating insulin resistance than fasting insulin in women with polycystic ovarian syndrome. J Coll Physicians Surg Pak 2017;27:123-126.

Yamamoto Y, Hirose H, Saito I, Nishikai K, Saruta T. Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population. J Clin Endocrinol Metab 2004;89:87-90.

Polak K, Czyzyk A, Simoncini T, Meczekalski B. New markers of insulin resistance in polycystic ovary syndrome.J Endocrinol Invest 2017;40:1-8.

Yamashita S, Matsuzawa Y. Adiponectin: a key player in obesity related disorders. Curr Pharm Des 2010;16:1896-1901.

Allahbadia GN, Merchant R. Polycystic ovary syndrome and impact on health. Middle East Fertili Soc J 2011;16:19-37.

Jedel E, Labrie F, Oden A, Holm G, Nilsson L, Janson PO,et al. Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial.Am J Physiol Endocrinol Metab 2011;300:E37-E45.

Johansson J, Redman L, Veldhuis PP, Sazonova A, Labrie F, Holm G, et al. Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial.Am J Physiol Endocrinol Metab 2013;304:E934-E943.

Pastore LM, Williams CD, Jenkins J, Patrie JT. True and sham acupuncture produced similar frequency of ovulation and improved LH to FSH ratios in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2011;96:3143-3150.

Wu XK, Stener-Victorin E, Kuang HY, Ma HL, Gao JS, Xie LZ, et al. Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome: a randomized clinical trial. JAMA 2017;317:2502-2514.

Gang WJ, Jing XH. Is acupuncture actually not effective for polycystic ovary syndrome? Analysis of the trial published in JAMA. Chin J Integr Med 2017;23:883-886.

Wu JN, Qin ZS, Liu ZS. Pivotal factors concerned in design of acupuncture clinical research: from two articles in JAMA.Chin J Integr Med 2017;23:809-811.

Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC,Devereaux PJ, et al. CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials. BMJ 2010;340:c869-c869.

Wang Q, Huang DM, Wu XK, Wu S. Effect of low frequency electric acupuncture on menstrual frequency of young women with polycystic ovary syndrome: study protocol for a randomized, double-blinded, sham-controlled trial. Am Med J 2012;12:171-175.

Wang Z, Dong H, Wang Q, Zhang L, Wu X, et al. Effects of electroacupuncture on anxiety and depression in unmarried patients with polycystic ovarian syndrome: secondary analysis of a pilot randomised controlled trial. Acupunct Med 2019;37:40-46.

Kuang HY, Li Y, Wu X, Hou L, Wu T, Liu J, et al. Acupuncture and clomiphene citrate for live birth in polycystic ovary syndrome: study design of a randomized controlled trial. Evid Based Complement Alternat Med 2013;2013:527303.

Zheng SH, Li XL. Visceral adiposity index as a predictor of clinical severity and therapeutic outcome of PCOS. Gynecol Endocrinol 2016;32:177-183.

Morbiducci U, Di Benedetto G, Gaetano L, Kautzky-Willer A, Pacini G, Tura A. Predicting the metabolic condition after gestational diabetes mellitus from oral glucose tolerance test curves shape. Ann Biomed Eng 2014;42:1112-1120.

Lai MH, Ma HX, Yao H, Liu H, Song XH, Huang WY, et al.Effect of abdominal acupuncture therapy on the endocrine and metabolism in obesity-type polycystic ovarian syndrome patients. Acupunct Res (Chin) 2010;35:298-302.

Johansson J, Feng Y, Shao R, Lonn M, Billig H, Stener-Victorin E. Intense electroacupuncture normalizes insulin sensitivity, increases muscle GLUT4 content, and improves lipid profile in a rat model of polycystic ovary syndrome. Am J Physiol Endocrinol Metab 2010;299:E551-E559.

Maliqueo M, Benrick A, Marcondes RR, Johansson J, Sun M, Stener-Victorin E. Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome. Exp Physiol 2017;102:113-127.

Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011;11:85-97.

Meijer K, de Vries M, Al-Lahham S, Bruinenberg M,Weening D, Dijkstra M, et al. Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages. PLoS One 2011;6:e17154.

Remsberg K, Talbott E, Zborowski J, Evans R, McHugh-Pemu K. Evidence for competing effects of body mass,hyperinsulinemia, insulin resistance, and androgens on leptin levels among lean, overweight, and obese women with polycystic ovary syndrome. Fertil Steril 2002;78:479-486.

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