Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial*

Jie-mei GUO; Yan XIAO; Tang-yan CAI; Jian-hui WANG; Bao-lin LI; Lu-lu HUANG; Xiao MAO; Xing-quan LAI; Ya-ju ZHU; Yi-qiang ZHANG; Shao-qing CHEN; You-xin SU

doi:10.1007/s11655-021-3488-6

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Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial*

Original Article | Updated：2021-10-18

- Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial*
- Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial*
- Chinese Journal of Integrative Medicine 2021年27卷第10期页码：729-736
- Affiliations：
  
  1.Department of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou (350122), China
  2.Department of Clinical Medicine, Fujian Health College,Fuzhou (350101), China
  3.Department of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine,Fuzhou (350122), China
  4.Department of Rehabilitation, Fujian Tingzhou Hospital, Longyan, Fujian Province (366300), China
  5.Department of Emergency, Xiaogan Chinese Medicine Hospital,Xiaogan, Hubei Province (432100), China
  6.Department of Rehabilitation, Fuzhou First Hospital, Fuzhou (350009), China
  7.Fujian University of Traditional Chinese Medicine, Fuzhou(350122), China
- Author bio：
  
  Prof. SU You-xin, E-mail: suyouxin777@hotmail.com
- Funds：
  
  the State Administration of Traditional Chinese Medicine(201307004)
- DOI：10.1007/s11655-021-3488-6
  中图分类号：
- 纸质出版日期：2021-10-01，
  
  网络出版日期：2021-03-12，
  
  录用日期：2020-12-4
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Jie-mei GUO, Yan XIAO, Tang-yan CAI, 等. Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):729-736.

Jie-mei GUO, Yan XIAO, Tang-yan CAI, et al. Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):729-736.
Jie-mei GUO, Yan XIAO, Tang-yan CAI, 等. Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):729-736. DOI： 10.1007/s11655-021-3488-6.

Jie-mei GUO, Yan XIAO, Tang-yan CAI, et al. Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):729-736. DOI： 10.1007/s11655-021-3488-6.

摘要

Abstract

Objective:

To determine the effects of Chinese medicine (CM) involving triple rehabilitation therapy on the progression of knee osteoarthritis (KOA).

Methods:

A total of 722 patients recruited from 38 community health service centers located in China from March 2013 to March 2017 were randomly divided into treatment and control groups equally

using a cluster randomization design. Health education combined with CM involving triple rehabilitation therapy for KOA (electro-acupuncture

Chinese medicinal herb fumigating-washing

and traditional exercises) was administered in the treatment group while conventional rehabilitation therapy (physical factor therapy

joint movement training

and muscle strength training) was administered in the control group. Patients with a visual analog scale (VAS) scores ≥4 were treated with dispersible meloxicam tablets (7.5 mg

once daily). The Lequesne index scores

VAS scores

range of motion (ROM)

lower limb muscle strength

knee joint circumference

quantitative scores of KOA symptoms

and the short-form 36 item health survey questionnaire (SF-36) scores were measured for each patient at 5 checkpoints (before treatment

at the 2nd week and the 4th week during the 4-week treatment period

at 1 month and 3 months after end of treatment)

and adverse reactions were observed also.

Results:

A total of 696 patients completed the entire process

with 351 in the treatment group and 345 in the control group. At all treatment checkpoints

the treatment group demonstrated better outcomes than the control group with regard to the total Lequesne index scores

effective rate and improvement rate of the total Lequesne index scores

VAS scores

lower limb muscle strength

knee circumference

quantitative scores of KOA symptoms

and SF-36 scores as well (

0.05 or

0.01). No adverse reactions were encountered in this study.

Conclusions:

CM involving triple rehabilitation therapy can alleviate KOA-related pain and swelling

improve lower limb muscle strength

promote flexion and activity of the knee and improve the quality of life in patients undergoing KOA. It is suitable for patients with early or mid-stage KOA. (Registration No. ChiCTR-TRC-12002538)

关键词

Keywords

knee osteoarthritisChinese medicine involving triple rehabilitation therapyelectro-acupunctureChinese medicinal herb fumigating-washingtraditional exercisescommunity rehabilitation

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