Chinese Herbal Medicine for Systemic Lupus Erythematosus:A Systematic Review and Meta-Analysis of Randomized,Placebo-Controlled Trials*

Ying WANG; Mei HAN; Christopher E. Pedigo; Zhi-min XIE; Wei-jie WANG; Jian-ping LIU

doi:10.1007/s11655-021-3497-0

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Chinese Herbal Medicine for Systemic Lupus Erythematosus:A Systematic Review and Meta-Analysis of Randomized,Placebo-Controlled Trials*

Evidence-Based Integrative Medicine | Updated：2021-10-18

- Chinese Herbal Medicine for Systemic Lupus Erythematosus:A Systematic Review and Meta-Analysis of Randomized,Placebo-Controlled Trials*
- Chinese Herbal Medicine for Systemic Lupus Erythematosus:A Systematic Review and Meta-Analysis of Randomized,Placebo-Controlled Trials*
- Chinese Journal of Integrative Medicine 2021年27卷第10期页码：778-787
- Affiliations：
  
  1.Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing (100029), China
  2.Department of Internal Medicine, Yale University School of Medicine, Connecticut (06520), USA
  3.Department of Rheumatology, the Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou (310005),China
- Author bio：
  
  Prof. LIU Jian-ping, E-mail: liujp@bucm.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(81830115);the China Scholarship Council(201606555023)
- DOI：10.1007/s11655-021-3497-0
  中图分类号：
- 纸质出版日期：2021-10-01，
  
  网络出版日期：2021-07-28，
  
  录用日期：2020-12-21
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Ying WANG, Mei HAN, Christopher E. Pedigo, 等. Chinese Herbal Medicine for Systemic Lupus Erythematosus:A Systematic Review and Meta-Analysis of Randomized,Placebo-Controlled Trials*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):778-787.

Ying WANG, Mei HAN, Christopher E. Pedigo, et al. Chinese Herbal Medicine for Systemic Lupus Erythematosus:A Systematic Review and Meta-Analysis of Randomized,Placebo-Controlled Trials*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):778-787.
Ying WANG, Mei HAN, Christopher E. Pedigo, 等. Chinese Herbal Medicine for Systemic Lupus Erythematosus:A Systematic Review and Meta-Analysis of Randomized,Placebo-Controlled Trials*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):778-787. DOI： 10.1007/s11655-021-3497-0.

Ying WANG, Mei HAN, Christopher E. Pedigo, et al. Chinese Herbal Medicine for Systemic Lupus Erythematosus:A Systematic Review and Meta-Analysis of Randomized,Placebo-Controlled Trials*[J]. Chinese Journal of Integrative Medicine, 2021,27(10):778-787. DOI： 10.1007/s11655-021-3497-0.

摘要

Abstract

Objective:

To provide evidence on the efficacy and safety of Chinese herbal medicine (CHM) as interventions for systemic lupus erythematosus (SLE).

Methods:

Seven electronic databases

including the Cochrane Library

Chinese National Knowledge Infrastructure (CNKI)

Chinese Scientific Journal Database (VIP)

Chinese Biomedical Literature Service System (SinoMed)

Wanfang

Embase

and PubMed

were comprehensively searched

from their inception to August 16

2020

for all randomized controlled trials (RCTs) that focused on CHM used alone or in combination with conventional medicine for SLE. Outcomes were SLE activity index (SLEDAI)

traditional Chinese medicine symptom/syndrome score (TCMSS)

dosage of glucocorticoids

main serological testing

and incidence of adverse events. Data were extracted and pooled using Review Manager 5.3 software.

Results:

A total of 13 RCTs enrolling 856 participants met our inclusion criteria. Meta-analyses showed that

compared to placebo

CHM had statistically significant effect on reducing SLEDAI score (MD=–1.74

95% CI: –2.29 to –1.18)

diminishing TCMSS (SMD=–0.89

95% CI: –1.16 to –0.62)

decreasing dosage of glucocorticoids (MD=–2.41 mg/d

95% CI: –3.34 to –1.48)

lowering erythrocyte sedimentation rate (MD=–4.78 mm/h

95% CI: –8.86 to –0.71)

and increasing serum complement C4 level (MD=0.03 mg/dL

95% CI: 0.00 to 0.06). No significant difference was found between CHM and placebo on adverse events.

Conclusions:

CHM provided significant beneficial effect on controlling disease activity and reducing dose of glucocorticoids used among SLE patients. Future advanced designed RCTs for CHM treating moderate to severe SLE with multicenter and longer follow-up are urgently needed.

关键词

Keywords

Chinese herbal medicinesystemic lupus erythematoussystematic review and meta-analysisrandomized controlled trials

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