皮肤试验并不适用于预测中药注射剂的过敏反应

Chun-xiao LYU; Jun-hua ZHANG; Bao-he WANG; Bo-li ZHANG; Chang-xiao LIU; Yan-fen LI; Yu-hong HUANG

doi:10.1007/s11655-021-3523-2

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皮肤试验并不适用于预测中药注射剂的过敏反应

Original Article | Updated：2022-03-18

- 皮肤试验并不适用于预测中药注射剂的过敏反应
- Ineffectiveness of Skin Tests in Predicting Allergic Reactions Induced by Chinese Herbal Injections
- Chinese Journal of Integrative Medicine 2022年28卷第1期页码：36-42
- Affiliations：
  
  1.Department of Clinical Pharmacology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin (300250), China
  2.Research Institute of Traditional Chinese Medicine, Evidence-Based Medicine Centre, Tianjin University of Traditional Chinese Medicine, Tianjin (300250),China
  3.Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine,Tianjin (300250), China
  4.State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin (300250), China
- Author bio：
  
  Prof. HUANG Yu-hong, E-mail: hyh101@126.com
- Funds：
  
  National Major Science and Technology Projects of China(2012ZX09303010-001;2018ZX09734-002)
- DOI：10.1007/s11655-021-3523-2
  中图分类号：
- 纸质出版日期：2022-01-01，
  
  网络出版日期：2021-11-24，
  
  录用日期：2021-05-25
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Chun-xiao LYU, Jun-hua ZHANG, Bao-he WANG, 等. 皮肤试验并不适用于预测中药注射剂的过敏反应[J]. Chinese Journal of Integrative Medicine, 2022,28(1):36-42.

Chun-xiao LYU, Jun-hua ZHANG, Bao-he WANG, et al. Ineffectiveness of Skin Tests in Predicting Allergic Reactions Induced by Chinese Herbal Injections[J]. Chinese Journal of Integrative Medicine, 2022,28(1):36-42.
Chun-xiao LYU, Jun-hua ZHANG, Bao-he WANG, 等. 皮肤试验并不适用于预测中药注射剂的过敏反应[J]. Chinese Journal of Integrative Medicine, 2022,28(1):36-42. DOI： 10.1007/s11655-021-3523-2.

Chun-xiao LYU, Jun-hua ZHANG, Bao-he WANG, et al. Ineffectiveness of Skin Tests in Predicting Allergic Reactions Induced by Chinese Herbal Injections[J]. Chinese Journal of Integrative Medicine, 2022,28(1):36-42. DOI： 10.1007/s11655-021-3523-2.

摘要

目的:

评估皮肤试验是否适合预测中药注射剂引起的过敏反应.

方法:

针对银杏内酯注射液、银杏二萜内酯葡胺注射液和注射用丹参多酚酸三种中药注射剂

对249名健康受试者和180例过敏患者进行皮肤试验

包括皮肤点刺试验 (SPT) 、皮内试验 (IDT) 和激发试验 (包括皮下试验和静脉注射试验) . 激发试验结果被用作确定皮肤试验敏感性和特异性的 "金标准" .

结果:

在皮肤试验和激发试验中

健康受试者组和过敏受试者组比较

未见明显差异 (

0.05) . SPT和IDT的特异性分别为0.976和0.797

敏感性均为0.

结论:

皮肤试验可能不足以预测CHIs引起的过敏反应.

Abstract

Objective:

To evaluate whether skin tests are suitable to predict the allergy reactions induced by Chinese herbal injections (CHIs).

Methods:

The skin tests including skin prick tests (SPT)

intradermal tests (IDT) and provocation tests including subcutaneous tests and intravenous tests were administered to 249 healthy subjects and 180 allergic patients for 3 CHIs

including ginkgolide injection

diterpene ginkgolide meglumine injection and Salvianolate lyophilized injection. The results of the provocation tests were used as the "gold standard" to determine the sensitivity and specificity of the skin tests.

Results:

The results did not show any significant differences between the healthy and allergy groups in both skin tests and provocation tests (

0.05). The specificities of SPT and IDT were 0.976 and 0.797

respectively

and the sensitivities of both SPT and IDT were 0.

Conclusion:

Skin tests are insufficient to predict the likelihood of allergic reactions resulting from CHIs. (ChiCTR-CPC-15006921)

关键词

Keywords

adverse drug reactionsallergic reactionsChinese herbal injectionsskin tests

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