Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies

Chan-Young Kwon; Hyo-Weon Suh; Jong Woo Kim; Sun-Yong Chung

doi:10.1007/s11655-022-3506-3

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Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies

Literature Research | Updated：2022-03-18

- Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies
- Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies
- Chinese Journal of Integrative Medicine 2022年28卷第3期页码：263-271
- Affiliations：
  
  1.Department of Oriental Neuropsychiatry, Dong-eui University College of Korean Medicine, Busan (47227), Republic of Korea
  2.Department of Neuropsychiatry, Kyung Hee University Korean Medicine Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul (05278), Republic of Korea
- Author bio：
  
  Prof. Sun-Yong Chung, E-mail: lovepwr@khu.ac.kr
- Funds：
  
  the Grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute,Funded by the Ministry of Health & Welfare, Republic of Korea(HF20C0079)
- DOI：10.1007/s11655-022-3506-3
  中图分类号：
- 纸质出版日期：2022-03-01，
  
  网络出版日期：2022-01-27，
  
  录用日期：2020-07-24
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Chan-Young Kwon, Hyo-Weon Suh, Jong Woo Kim, 等. Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies[J]. Chinese Journal of Integrative Medicine, 2022,28(3):263-271.

Chan-Young Kwon, Hyo-Weon Suh, Jong Woo Kim, et al. Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies[J]. Chinese Journal of Integrative Medicine, 2022,28(3):263-271.
Chan-Young Kwon, Hyo-Weon Suh, Jong Woo Kim, 等. Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies[J]. Chinese Journal of Integrative Medicine, 2022,28(3):263-271. DOI： 10.1007/s11655-022-3506-3.

Chan-Young Kwon, Hyo-Weon Suh, Jong Woo Kim, et al. Anti-anger Effects of Herbal Medicine:A Mini-Review of Rat Studies[J]. Chinese Journal of Integrative Medicine, 2022,28(3):263-271. DOI： 10.1007/s11655-022-3506-3.

摘要

Abstract

Objective:

To analyze the available data on the anti-anger effects of herbal medicines (HMs) as well as their underlying mechanisms in rat models.

Methods:

From 6 electronic databases [PubMed

EMBASE

China National Knowledge Infrastructure (CNKI)

Wanfang

Oriental Medicine Advanced Searching Integrated System (OASIS)

and Research Information Sharing Service (RISS)]

relevant animal experiments were searched by using "anger

" "rats

" and "animal" as search keywords. The last search was conducted on November 22

2019

and all experiments involving rat models of anger and treatment using HMs published until the date of the search were considered.

Results:

A total of 24 studies with 16 kinds of HMs were included. Most studies have used the "tail irritating method" and "social isolation and resident intruder" method to establish anger models. According to the included studies

the therapeutic mechanisms of HMs for anger regulation and important herbs by their frequency and/or preclinical evidence mainly incladed regulation of hemorheology (

Bupleuri Radix

Paeoniae Radix Alba

and

Glycyrrhizae Radix

)

regulation of sex hormones (

Bupleuri Radix

Cyperi Rhizoma

and

Paeoniae Radix Alba

)

regulation of neurotransmitters (

Cyperi Rhizoma

)

regulation of anger-related genes (

Bupleuri Radix

Glycyrrhizae Radix

and

Paeoniae Radix Alba

)

and other effects. Overall

Liver (Gan) qi-smoothing herbs including

Bupleuri Radix

and

Cyperi Rhizoma

were the most frequently used.

Conclusions:

This review found the frequent methods to establish an anger model

and major mechanisms of anti-anger effects of HMs. Interestingly

some Liver qi-smoothing herbs have been frequently used to investigate the anti-anger effects of HM. These findings provide insight into the role and relevance of HMs in the field of anger management.

关键词

Keywords

angeranger management therapyherbal medicineKorean traditional medicine

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