针刺治疗阿尔茨海默病线粒体功能紊乱的机制探讨

Yu-hang JIANG; Jia-kai HE; Ran LI; Ze-hao CHEN; Bao-hui JIA

doi:10.1007/s11655-022-3511-6

Your Location：

Home >

Browse articles >

针刺治疗阿尔茨海默病线粒体功能紊乱的机制探讨

Review | Updated：2022-03-18

- 针刺治疗阿尔茨海默病线粒体功能紊乱的机制探讨
- Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage
- Chinese Journal of Integrative Medicine 2022年28卷第3期页码：272-280
- Affiliations：
  
  Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing (100053), China
- Author bio：
  
  Prof. JIA Bao-hui, E-mail: myrroossee@aliyun.com
- Funds：
  
  Science and Technology Innovation Projects(CI2021A03519);"The Belt and Road Initiative" International Cooperation Project Funded by China Academy of Chinese Medical Sciences
- DOI：10.1007/s11655-022-3511-6
  中图分类号：
- 纸质出版日期：2022-03-01，
  
  录用日期：2021-12-15
Scan for full text
Yu-hang JIANG, Jia-kai HE, Ran LI, 等. 针刺治疗阿尔茨海默病线粒体功能紊乱的机制探讨[J]. Chinese Journal of Integrative Medicine, 2022,28(3):272-280.

Yu-hang JIANG, Jia-kai HE, Ran LI, et al. Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage[J]. Chinese Journal of Integrative Medicine, 2022,28(3):272-280.
Yu-hang JIANG, Jia-kai HE, Ran LI, 等. 针刺治疗阿尔茨海默病线粒体功能紊乱的机制探讨[J]. Chinese Journal of Integrative Medicine, 2022,28(3):272-280. DOI： 10.1007/s11655-022-3511-6.

Yu-hang JIANG, Jia-kai HE, Ran LI, et al. Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage[J]. Chinese Journal of Integrative Medicine, 2022,28(3):272-280. DOI： 10.1007/s11655-022-3511-6.

摘要

阿尔茨海默病(AD)是老年人中最常见的神经退行性疾病之一

约占所有痴呆类型的80%. 迄今为止

AD的发病机制仍未完全阐明. 线粒体级联假说认为线粒体损伤可能介导、驱动或加速多种AD病理进展

是导致晚发型AD的主要因素. 目前

尚无明确证实可有效治疗AD线粒体损伤的药物

越来越多的证据表明针刺可以有效改善AD线粒体结构和保护线粒体功能. 本文总结了针刺调节线粒体动力学、提高能量代谢、维持钙稳态和抑制细胞凋亡的机制

以期为针刺治疗AD提供科学的理论依据.

Abstract

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases among the elderly and it accounts for nearly 80% of all dementias. The pathogenesis of AD is complicated and enigmatic thus far. The mitochondrial cascade hypothesis assumes that mitochondrial damage may mediate

drive

or contribute to a variety of AD pathologies and may be the main factor in late-onset AD. Currently

there are no widely recognized drugs able to attenuate mitochondrial damage in AD. Notably

increasing evidence supports the efficacy of acupuncture for improving the mitochondrial structure and protecting mitochondrial functions in AD. This review reports the mechanisms by which acupuncture regulates mitochondrial dynamics

energy metabolism

calcium homeostasis and apoptosis. In conclusion

these findings suggest that AD mitochondrial dysfunction represents a reasonable therapeutic target and acupuncture could play a significant role in preventing and treating AD.

关键词

Keywords

acupunctureAlzheimer's diseasemitochondrial damagereview

references

Scheltens P, Blennow K, Breteler MM, et al. Alzheimer's disease. Lancet 2016;388:505-517.

Prince M, Ali GC, Guerchet M, et al. Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimer's Res Ther 2016;8:23-26.

Cheng ST. Dementia caregiver burden: a research update and critical analysis. Curr Psychiatry Rep 2017;19:64-72.

Sevigny J, Chiao P, Bussiere T, et al. The antibody aducanumab reduces Abeta plaques in Alzheimer's disease. Nature 2016;537:50-56.

Naseri NN, Wang H, Guo J, et al. The complexity of tau in Alzheimer's disease. Neurosci Lett 2019;705:183-194.

Tonnies E, Trushina E. Oxidative stress, synaptic dysfunction, and Alzheimer's disease. J Alzheimer's Dis 2017;57:1105-1121.

Sochocka M, Donskow LK, Diniz BS, et al. The gut microbiome alterations and inflammation-driven pathogenesis of Alzheimer's disease—a critical review. Mol Neurobiol 2019;56:1841-1851.

Swerdlow RH, Burns JM, Khan SM. The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives. Biochim Biophys Acta 2014;1842:1219-1231.

Kellar D, Craft S. Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches. Lancet Neurol 2020;19:758-766.

Bostanciklioglu M. The role of gut microbiota in pathogenesis of Alzheimer's disease. J Appl Microbiol 2019;127:954-967.

Chen YG. Research progress in the pathogenesis of Alzheimer's disease. Chin Med J 2018,131:1618-1624.

Swerdlow RH. Mitochondria and mitochondrial cascades in Alzheimer's disease. J Alzheimer's Dis 2018;62:1403-1416.

Grimm A, Friedland K, Eckert A. Mitochondrial dysfunction:the missing link between aging and sporadic Alzheimer's disease. Biogerontology 2016;17:281-296.

Wang YY, Yu SF, Xue HY, et al. Effectiveness and safety of acupuncture for the treatment of Alzheimer's disease: a systematic review and meta-analysis. Front Aging Neurosci 2020;12:98.

Huang J, Shen M, Qin X, et al. Acupuncture for the treatment of Alzheimer's disease: an overview of systematic reviews. Front Aging Neurosci 2020;12:574023.

Niyazov DM, Kahler SG, Frye RE. Primary mitochondrial disease and secondary mitochondrial dysfunction:importance of distinction for diagnosis and treatment. Mol Syndromol 2016;7:122-137.

Cadonic C, Sabbir MG, Albensi BC. Mechanisms of mitochondrial dysfunction in Alzheimer's disease. Mol Neurobiol 2016;53:6078-6090.

Swerdlow RH. Mitochondria and cell bioenergetics:increasingly recognized components and a possible etiologic cause of Alzheimer's disease. Antioxid Redox Signal 2012;16:1434-1455.

Xie H, Guan J, Borrelli LA, et al. Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model. J Neurosci 2013;33:17042-17051.

Wang X, Wang W, Li L, et al. Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochim Biophys Acta 2014;1842:1240-1247.

Flannery PJ, Trushina E. Mitochondrial dynamics and transport in Alzheimer's disease. Mol Cell Neurosci 2019;98:109-120.

Cagalinec M, Safiulina D, Liiv M, et al. Principles of the mitochondrial fusion and fission cycle in neurons. J Cell Sci 2013;126:2187-2197.

Selfridge JE, E L , Lu J, et al. Role of mitochondrial homeostasis and dynamics in Alzheimer's disease.Neurobiol Dis 2013;51:3-12.

Reddy PH, Tripathi R, Troung Q, et al. Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics. Biochim Biophys Acta 2012;1822:639-649.

Li YY, Li GC, Zhu H, et al. Effects of acupuncture on behaviors, expressions of Fis1 and OPA1, and mitochondrial ultrastructure of mice model of Alzheimer's disease. Chin J Inf Tradit Chin Med (Chin) 2018;25:59-64.

Liang J. Effect of acupuncture at "Si-Guan points" (Taichong LR-3 combine with Hegu LI-4) on mitochondrion division and fusion of the frontal lobe of AD rats [Dissertation].Shijiazhuang: Hebei Medical University;2016.

He X, Yu J, Sun GJ, et al. The effect of 'Kidney-reinforcing and Du Meridian-regulating' acupuncture-moxibustion on mitofusin-1/2 in hippocampal neurons of rat model with Alzheimer's disease. Chin Prev Med (Chin) 2014;15:187-190.

Peng J, Zeng F, He YH, et al. Observation on the protective effect of electro-acupuncture on hippocampal neuronal mitochondria in SAMP8 mice. Acupunct Res (Chin)2007;32:364-367.

Zhu SX, Sun GJ. Effect of electro-acupuncture on activation of glial cells and neuronic ultrastructure in hippocampus of Alzheimer 's rats. J Tradit Chin Med (Chin) 2009;50:522-525.

Xue WG, Ge GL, Zhang Z, et al. Effect of electroacupuncture on the behavior and hippocampal ultrastructure in APP transgenic mice. Acupunct Res (Chin) 2009;34:309-314.

Sun GJ, Luo L, Du YJ, et al. Protective mechanism of acupuncture-moxibustion on hippocampal neuron mitochondria in rats with Alzheimer's disease. Chin Acupunct Moxibust (Chin) 2014;34:157-162.

He YH. Influence of electro-acupuncture therapy on the mitochondrial ultrastructure and apoptosis protein in hippocampal neuron of SAMP8 mice [Dissertation]. Chengdu:Chengdu University of Traditional Chinese Medicine;2007.

Federico A, Cardaioli E, Da PP, et al. Mitochondria, oxidative stress and neurodegeneration. J Neurol Sci 2012;322:254-262.

Chou JL, Shenoy DV, Thomas N, et al. Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease. J Proteomics 2011;74:466-479.

Smailagic N, Lafortune L, Kelly S, et al. 18F-FDG PET for prediction of conversion to Alzheimer's disease dementia in people with mild cognitive impairment: an updated systematic review of test accuracy. J Alzheimer's Dis 2018;64:1175-1194.

Bateman RJ, Xiong C, Benzinger TL, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 2012;367:795-804.

Wang W, Zhao F, Ma X, et al. Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances.Mol Neurodegener 2020;15:30-55.

Hattori N, Kitagawa K, Higashida T, et al. CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains.Neurosci Lett 1998;254:141-144.

D'Eletto M, Rossin F, Occhigrossi L, et al. Transglutaminase type 2 regulates ER-mitochondria contact sites by interacting with GRP75. Cell Rep 2018;25:3573-3581.

Le PT, Cheng H, Ninkovic S, et al. Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kalpha and mTOR. Bioorg Med Chem Lett 2012;22:5098-5103.

Morsy A, Trippier PC. Amyloid-binding alcohol dehydrogenase (ABAD) inhibitors for the treatment of Alzheimer's disease. J Med Chem 2019;62:4252-4264.

Zeng F. Electro-acupuncture therapy on the mitochondrial enzymatic activities of hippocampal neuron of animal model of Alzheimer's disease [Dissertation]. Chengdu: Chendu University of Chinese Medicine;2005.

Peng J. Electro-acupuncture therapy on the mitochondrial energy disorder of hippocampal neuron of animal model of Alzheimer's disease [Dissertation]. Chengdu: Chendu University of Chinese Medicine; 2008.

Dong WG, Chen CY, Lin L, et al. Effect of electroacupuncture on respiratory chain complex enzyme activity in SAMP8 mouse hippocampine mitochondria.Shanghai Acupunct Moxibust J (Chin) 2012;31:524-527.

Dong WG, Lin L, Wang F, et al. Effects of electroacupuncture on the function of respiration chain in hippocampal mitochondria of SAMP8 mice. Chin Acupunct Moxibust (Chin) 2012;32:726-730.

Zong CZ, Guo YX, Han YS. Effects of acupuncture at Zusanli and Guanyuan points on ion pump ATPase and mitochondrial body density in hippocampus of AD Rats.Acupunct Clin J (Chin) 2007;23:46-47.

Luo L, Sun GJ, Du YJ. Effects of acupuncture and moxibustion on energy metabolism-related protein of hippocampal neuron mitochondria in Alzheimer's disease rats. Chin Acupunct Moxibust (Chin) 2013;33:913-918.

Rizzuto R, Pinton P, Brini M, et al. Mitochondria as biosensors of calcium microdomains. Cell Calcium 1999;26:193-199.

Payne R, Hoff H, Roskowski A, et al. MICU2 restricts spatial crosstalk between InsP3R and MCU channels by regulating threshold and gain of MICU1-mediated inhibition and activation of MCU. Cell Rep 2017;21:3141-3154.

Abeti R, Abramov AY. Mitochondrial Ca(2+) in neurodegenerative disorders. Pharmacol Res 2015;99:377-381.

Laferla FM. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci 2002;3:862-872.

Raza M, Deshpande LS, Blair RE, et al. Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons. Neurosci Lett 2007;418:77-81.

Zhang L, Liu F, Wan SG, et al. Alteration of cytosolic calcium in mtDNA-transferred cells of Alzheimer's disease.J Capit Med Univ (Chin) 2011;32:67-72.

Khachaturian ZS. Hypothesis on the regulation of cytosol calcium concentration and the aging brain. Neurobiol Aging 1987;8:345-346.

Wu AJ, Tong BC, Huang AS, et al Mitochondrial calcium signaling as a therapeutic target for Alzheimer's disease.Curr Alzheimer Res 2020;17:329-343.

Vella D, Zoppis I, Mauri G, et al. From protein-protein interactions to protein co-expression networks: a new perspective to evaluate large-scale proteomic data.EURASIP J Bioinf Syst Biol 2017;2017:6-22.

Smilansky A, Dangoor L, Nakdimon I, et al. The voltage-dependent anion channel 1 mediates amyloid beta toxicity and represents a potential target for Alzheimer's disease therapy. J Biol Chem 2015;290:30670-30683.

Manczak M, Reddy PH. Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. Hum Mol Genet 2012;21:5131-5146.

Reddy PH. Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease? Biochim Biophys Acta 2013;1832:67-75.

Ben-Hail D, Shoshan-Barmatz V. VDAC1-interacting anion transport inhibitors inhibit VDAC1 oligomerization and apoptosis. Biochim Biophys Acta 2016;1863:1612-1623.

Bertero E, Maack C. Calcium signaling and reactive oxygen species in mitochondria. Circ Res 2018;122:1460-1478.

Calvo-Rodriguez M, Hernando-Perez E, Nunez L, et al. Amyloid beta oligomers increase ER-mitochondria Ca(2+) cross talk in young hippocampal neurons and exacerbate aging-induced intracellular Ca(2+) remodeling. Front Cell Neurosci 2019;13:22.

Boyman L, Williams GS, Khananshvili D, et al. NCLX: the mitochondrial sodium calcium exchanger. J Mol Cell Cardiol 2013;59:205-213.

Jadiya P, Kolmetzky DW, Tomar D, et al. Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease. Nat Commun 2019;10:3885-3899.

Ludtmann M, Kostic M, Horne A, et al. LRRK2 deficiency induced mitochondrial Ca(2+) efflux inhibition can be rescued by Na(+)/Ca(2+)/Li(+) exchanger upregulation. Cell Death Dis 2019;10:265-275.

Hao TT, Fu Y, Xing J, et al. Acupuncture influence to mitochondria calcium ions' concentrations and reactive oxygen species of SAMP8 mice. J Tianjin Univ Tradit Chin Med (Chin) 2013;32:217-220.

Estaquier J, Vallette F, Vayssiere JL, et al. The mitochondrial pathways of apoptosis. Adv Exp Med Biol 2012;942:157-183.

Raina AK, Hochman A, Ickes H, et al. Apoptotic promoters and inhibitors in Alzheimer's disease: who wins out? Prog Neuropsychopharmacol Biol Psychiatry 2003;27:251-254.

Rossler M, Zarski R, Bohl J, et al. Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer's disease. Acta Neuropathol 2002;103:363-369.

Wu Y, Chen M, Jiang J. Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion 2019;49:35-45.

Bock F J, Tait S. Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol 2020;21:85-100.

Jordan J, Cena V, Prehn JH. Mitochondrial control of neuron death and its role in neurodegenerative disorders. J Physiol Biochem 2003;59:129-141.

Karch J, Molkentin JD. Identifying the components of the elusive mitochondrial permeability transition pore. Proc Natl Acad Sci USA 2014;111:10396-10397.

Biasutto L, Azzolini M, Szabo I, Zoratti M. The mitochondrial permeability transition pore in AD 2016: an update. Biochim Biophys Acta 2016;1863:2515-2530.

Wang L, Xing J, Guo RJ, et al. Effect of triple energizer acupuncture method on the activity regulation of mitochondrial membrane channel and neuronal apoptosis in dementia mice. Acupunct Clin J (Chin) 2018;34:59-62.

Du YJ, Sun GJ, Kang YP. Effect of moxibustion on mitochondrial release proteins Bcl-2, Bax in apoptotic signaling pathway in AD rats. Chin Arch Tradit Chin Med(Chin) 2006;24:1679-1680.

Cui Y. The effect of 'Yishentiaodu' acupuncture and moxibustion on hippocampus mitochondrial of COXⅣ,Cyp-D in AD rats [Dissertation]. Wuhan: Hubei University of Chinese Medicine;2014.

Fu Y, Xing J, Guo RJ, et al. Effect of acupuncture in regulating mitochondria permeability transition pore opening in Alzheimer's disease mice with mitochondrial dysfunction. J Tianjin Univ Tradit Chin Med (Chin) 2014;31:26-29.

Jia Y, Zhang X, Yu J, et al. Acupuncture for patients with mild to moderate Alzheimer's disease: a randomized controlled trial. BMC Complement Altern Med 2017;17:556-564.

Yu CC, Du YJ, Wang SQ, et al. Experimental evidence of the benefits of acupuncture for Alzheimer's disease: an updated review. Front Neurosci 2020;14:549772.

Cai MD, Lee JH, Yang EJ. Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer's disease animal model. Front Aging Neurosci 2019;16:264-276.

Cao J, Tang YS, Li YJ, et al. Behavioral changes and hippocampus glucose metabolism in APP/PS1 transgenic mice via electro-acupuncture at governor vessel acupoints.Front Aging Neurosci 2017;9:5

Lee J, Kim Y, Liu T, et al. SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease. Aging Cell 2018;17:e12679.

Yuan Y, Cruzat V F, Newsholme P, et al. Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis. Mech Ageing Dev 2016;155:10-21.

Hooper C, Meimaridou E, Tavassoli M, et al. p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells. Neurosci Lett 2007;418:34-37.

Chu CT. Mechanisms of selective autophagy and mitophagy: implications for neurodegenerative diseases.Neurobiol Dis 2019;122:23-34.

Fang EF, Hou Y, Palikaras K, et al. Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nat Neurosci 2019;22:401-412.

Shevtsova EF, Maltsev AV, Vinogradova DV, et al.Mitochondria as a promising target for developing novel agents for treating Alzheimer's disease. Med Res Rev 2021;41:803-827.

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Effects of Acupuncture on Alzheimer's Disease: Evidence from Neuroimaging Studies

Protective Effects of Phellodendron Species on Bone Health:A Novel Perspective on Their Potentials in Treating Osteoporosis and Osteoarthritis

Factors and Their Impact on Treatment Effect of Acupuncture in Different Outcomes: A Meta-Regression of Acupuncture Randomized Controlled Trials

Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

Advances in Phytochemistry and Modern Pharmacology of Saposhnikovia Divaricata (Turcz.) Schischk