Anti-inflammatory Effects of <italic style="font-style: italic">Ampelopsis Japonica</italic> Root on Contact Dermatitis in Mice

Yoona Oh; Hongbum Lee; Beodeul Yang; Kim Sura; Hyunwoo Jeong; Hyungwoo Kim

doi:10.1007/s11655-022-3517-0

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Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice

Original Article | Updated：2022-07-20

- Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice
- Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice
- Chinese Journal of Integrative Medicine 2022年28卷第8期页码：719-724
- Affiliations：
  
  1.Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam (50612), South Korea
  2.Department of Pathology, College of Korean Medicine, Dongshin University, Jeonnam (58245), South Korea
- Author bio：
  
  Prof. Hyungwoo Kim, E-mail: kronos7@pusan.ac.kr
- Funds：
  
  the National Research Foundation of Korea funded by the Korean Government(MSIP; No. 2018R1A2B6006031)
- DOI：10.1007/s11655-022-3517-0
  中图分类号：
- 纸质出版日期：2022-08，
  
  录用日期：2021-09-01
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Yoona Oh, Hongbum Lee, Beodeul Yang, 等. Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice[J]. Chinese Journal of Integrative Medicine, 2022,28(8):719-724.

Yoona Oh, Hongbum Lee, Beodeul Yang, et al. Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice[J]. Chinese Journal of Integrative Medicine, 2022,28(8):719-724.
Yoona Oh, Hongbum Lee, Beodeul Yang, 等. Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice[J]. Chinese Journal of Integrative Medicine, 2022,28(8):719-724. DOI： 10.1007/s11655-022-3517-0.

Yoona Oh, Hongbum Lee, Beodeul Yang, et al. Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice[J]. Chinese Journal of Integrative Medicine, 2022,28(8):719-724. DOI： 10.1007/s11655-022-3517-0.

摘要

Abstract

Objective:

To investigate the anti-inflammatory potential of

Ampelopsis japonica

on contact dermatitis (CD).

Methods:

A total of 38 Balb/c mice were divided into 5 groups by using a random number table: normal mice (

=6)

CD model mice (

=8)

CD mice treated with 3 or 30 mg/kg of the ethanol extract of

A. japonica

(EEAJ

=8) and 7.5 mg/kg dexamethasone treated CD mice (DEX

=8). CD was induced using topical application of 1-fluoro-2

4-dinitrofluorobenzene in mice. EEAJ and DEX were topically applied to the shaved skin of each mouse for 6 days

and the effects of EEAJ and DEX on skin lesions and color

histopathological abnormalities such as epidermal hyperplasia and immune cell infiltration

and tumor necrosis factor (TNF)-α

interleukin-6 (IL-6)

and monocyte chemoattractant protein-1 (MCP-1) production were investigated. The effects on changes in body weights and spleen/body weight ratio were also investigated.

Results:

EEAJ at 30 mg/kg significantly prevented scaling

erythema and enlargement of skin weight compared to using carbon dioxide. EEAJ also prevented epithelial hyperplasia and immune cell infiltrations induced by repeated application of DNFB (

0.01). In addition

EEAJ significantly lowered levels of TNF-α

IL-6 and MCP-1 (

0.05 or

0.01). The anti-inflammatory effects of EEAJ were similar to those of DEX.

Conclusion:

A. japonica may be a new therapeutic agent with the potential to reduce or replace corticosteroids and its mechanisms are closely related to regulation of TNF-α production.

关键词

Keywords

Ampelopsis japonicaChinese medicineinflammationdermatosiscontact dermatitis

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Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice

Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice

DOI：10.1007/s11655-022-3517-0

摘要

Abstract

关键词

Keywords

references