Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

ZHAO Wen-xiao; WANG Tong; ZHANG Ya-nan; CHEN Qian; WANG Yuan; XING Yan-qing; ZHENG Jun; DUAN Chen-chen; CHEN Li-jun; ZHAO Hai-jun; WANG Shi-jun

doi:10.1007/s11655-022-3522-y

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Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

Review | Updated：2024-02-22

- Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health
- Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health
- 中国结合医学杂志（英文版） 2024年30卷第2期页码：171-180
- Affiliations：
  
  1.School of Nursing, Shandong University of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan (250355), China
  2.Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula, Shandong University of Traditional Chinese Medicine, Ji'nan (250355), China
  3.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan (250355), China
- Author bio：
  
  Dr. ZHAO Hai-jun, E-mail: higherzhao@126.com
- Funds：
  
  the National Natural Science Foundation of China(81903947);the Key Research and Development Project of Shandong Province, China(2019GSF108209);Key Basic Research of the Natural Science Foundation of Shandong Province,China(ZR2019ZD23);Shandong University Youth Innovative Talent Introduction Project (LJRZ 2019)(9-201)
- DOI：10.1007/s11655-022-3522-y
  中图分类号：
- 纸质出版日期：2024-02，
  
  网络出版日期：2022-05-18，
  
  录用日期：2021-04-01
Scan for full text
Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health[J]. 中国结合医学杂志（英文版）, 2024,30(2):171-180.

ZHAO Wen-xiao, WANG Tong, ZHANG Ya-nan, et al. Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health[J]. Chinese Journal of Integrative Medicine, 2024,30(2):171-180.
Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health[J]. 中国结合医学杂志（英文版）, 2024,30(2):171-180. DOI： 10.1007/s11655-022-3522-y.

ZHAO Wen-xiao, WANG Tong, ZHANG Ya-nan, et al. Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health[J]. Chinese Journal of Integrative Medicine, 2024,30(2):171-180. DOI： 10.1007/s11655-022-3522-y.

摘要

Abstract

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity

type 2 diabetes mellitus

heart failure

and non-alcoholic fatty liver disease. Polysaccharides extracted from Chinese medicine (CM) can not only alleviate pathological status but also promote health by anti-inflammatory

regulating immunity

lowering blood glucose and lipids

anti-cancer

and anti-oxidation. The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment. In addition

they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota. This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics for promoting health.

关键词

Keywords

Chinese medicinepolysaccharidesgut microbiotashort-chain fatty acidslipopolysaccharidesgut-organ axissynergistic actions

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