Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis

LI Han; YE Xiao-feng; SU Yang-shuai; HE Wei; ZHANG Jian-bin; ZHANG Qi; ZHAN Li-bin; JING Xiang-hong

doi:10.1007/s11655-022-3531-x

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Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis

Review | Updated：2023-08-29

- Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis
- Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis
- 中国结合医学杂志（英文版） 2023年29卷第9期页码：847-857
- Affiliations：
  
  1.Department of Acupuncture and Moxibustion, Changzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Changzhou, Jiangsu Province (213002), China
  2.Nanjing University of Chinese Medicine, Nanjing (210023), China
  3.Research Center of Meridians, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing (100700), China
  4.Department of Acupuncture and Moxibustion, the Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing (211005), China
  5.Liaoning University of Chinese Medicine, Shenyang (116600), China
- Author bio：
  
  Prof. JING Xiang-hong, E-mail: jxhtjb@263.net
- Funds：
  
  National Key Research and Development Program of China(2019YFC1709002);National Natural Science Foundation of China(81973947;82004453);Natural Science Foundation of Nanjing University of Chinese Medicine(XZR2020043);Jiangsu Province Chinese Medicine Science and Technology Development Program(YB201951);Changzhou Science and Technology Program(CJ20190070);Changzhou Municipal Health Commission Science and Technology Program(QN 201939);Changzhou Municipal Health Qing Miao Talent Training Program(CZQM2020083)
- DOI：10.1007/s11655-022-3531-x
  中图分类号：
- 纸质出版日期：2023-09，
  
  网络出版日期：2022-04-12，
  
  录用日期：2021-12-02
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Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis[J]. 中国结合医学杂志（英文版）, 2023,29(9):847-857.

LI Han, YE Xiao-feng, SU Yang-shuai, et al. Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis[J]. Chinese Journal of Integrative Medicine, 2023,29(9):847-857.
Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis[J]. 中国结合医学杂志（英文版）, 2023,29(9):847-857. DOI： 10.1007/s11655-022-3531-x.

LI Han, YE Xiao-feng, SU Yang-shuai, et al. Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis[J]. Chinese Journal of Integrative Medicine, 2023,29(9):847-857. DOI： 10.1007/s11655-022-3531-x.

摘要

Abstract

The latest guideline about ulcerative colitis (UC) clinical practice stresses that mucosal healing

rather than anti-inflammation

is the main target in UC clinical management. Current mucosal dysfunction mainly closely relates to the endoscopic intestinal wall (mechanical barrier) injury with the imbalance between intestinal epithelial cells (IECs) regeneration and death

as well as tight junction (TJ) dysfunction. It is suggested that biological barrier (gut microbiota)

chemical barrier (mucus protein layer

MUC) and immune barrier (immune cells) all take part in the imbalance

leading to mechanical barrier injury. Lots of experimental studies reported that acupuncture and moxibustion on UC recovery by adjusting the gut microbiota

MUC and immune cells on multiple targets and pathways

which contributes to the balance of IEC regeneration and death

as well as TJ structure recovery in animals. Moreover

the validity and superiority of acupuncture and moxibustion were also demonstrated in clinic. This paper aims to review the achievements of acupuncture and moxibustion on mucosal healing and analyse the underlying mechanisms.

关键词

Keywords

acupuncture and moxibustionulcerative colitismucosal healingintestinal epithelial cells regeneration and deathtight junction functiongut microbiotareview

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