Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup

LIU Xiao-qing; ZHANG Run-shun; ZHOU Xue-zhong; ZHOU Hong; HE Yu-yao; HAN Shu; ZHANG Jing; SHU Zi-xin; ZHANG Xue-bin; JI Jing-hui; ZHONG Quan; ZHANG Li-li; MOU Zi-jun; HE Li-yun; ZHANG Lun-zhong; YANG Jie; HU Yan-jie; CHEN Zheng-guang; LI Xiao-zhen; TAN Yan; YAN Zhan-feng; CAO Ke-gang; MENG Wei; ZHAO He; ZHANG Wei; ZHONG Li-qun

doi:10.1007/s11655-022-3571-2

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Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup

Clinical Experience | Updated：2023-04-27

- Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup
- Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup
- 中国结合医学杂志（英文版） 2023年29卷第5期页码：441-447
- Affiliations：
  
  1.Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing (100700), China
  2.Department of Gastroenterology, Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing (100053), China
  3.School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining, Beijing Jiaotong University, Beijing (100044), China
  4.Department of Neurology, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong Province (261041), China
  5.Beijing Zhong Teng Bai Mai Medical Technology Co. Ltd., Beijing (100027), China
  6.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing (100700), China
  7.Department of Radiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing (100700), China
  8.School of Life Sciences, Beijing University of Chinese Medicine, Beijing (100029), China
  9.Department of Otolaryngology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing (100029), China
  10.Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (MA 02115), United States
- Author bio：
  
  Prof. ZHONG Li-qun, E-mail:zhongliqun163@163.com
- Funds：
  
  the National Key Research and Development Project of China(2017YFC1703502;2017YFC1703506)
- DOI：10.1007/s11655-022-3571-2
  中图分类号：
- 纸质出版日期：2023-05，
  
  网络出版日期：2022-06-20，
  
  录用日期：2020-09-25
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Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup[J]. 中国结合医学杂志（英文版）, 2023,29(5):441-447.

LIU Xiao-qing, ZHANG Run-shun, ZHOU Xue-zhong, et al. Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup[J]. Chinese Journal of Integrative Medicine, 2023,29(5):441-447.
Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup[J]. 中国结合医学杂志（英文版）, 2023,29(5):441-447. DOI： 10.1007/s11655-022-3571-2.

LIU Xiao-qing, ZHANG Run-shun, ZHOU Xue-zhong, et al. Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup[J]. Chinese Journal of Integrative Medicine, 2023,29(5):441-447. DOI： 10.1007/s11655-022-3571-2.

摘要

Abstract

Objective:

To derive the Chinese medicine (CM) syndrome classification and subgroup syndrome characteristics of ischemic stroke patients.

Methods:

By extracting the CM clinical electronic medical records (EMRs) of 7

170 hospitalized patients with ischemic stroke from 2016 to 2018 at Weifang Hospital of Traditional Chinese Medicine

Shandong Province

China

a patient similarity network (PSN) was constructed based on the symptomatic phenotype of the patients. Thereafter the efficient community detection method BGLL was used to identify subgroups of patients. Finally

subgroups with a large number of cases were selected to analyze the specific manifestations of clinical symptoms and CM syndromes in each subgroup.

Results:

Seven main subgroups of patients with specific symptom characteristics were identified

including M3

M29 and M4. M3 and M0 subgroups had prominent posterior circulatory symptoms

while M3 was associated with autonomic disorders

and M4 manifested as anxiety; M2 and M4 had motor and motor coordination disorders; M1 had sensory disorders; M5 had more obvious lung infections; M29 had a disorder of consciousness. The specificity of CM syndromes of each subgroup was as follows. M3

M29 and M4 all had the same syndrome as wind phlegm pattern; M3 and M0 both showed hyperactivity of Gan (Liver) yang pattern; M2 and M29 had similar syndromes

which corresponded to intertwined phlegm and blood stasis pattern and phlegm-stasis obstructing meridians pattern

respectively. The manifestations of CM syndromes often appeared in a combination of 2 or more syndrome elements. The most common combination of these 7 subgroups was wind-phlegm. The 7 subgroups of CM syndrome elements were specifically manifested as pathogenic wind

pathogenic phlegm

and deficiency pathogens.

Conclusions:

There were 7 main symptom similarity-based subgroups in ischemic stroke patients

and their specific characteristics were obvious. The main syndromes were wind phlegm pattern and hyperactivity of Gan yang pattern.

关键词

Keywords

ischemic strokepatient similarity networksubgroupsyndromeChinese medicine

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