Euphorbiaceae

is a large family of dicotyledonous angiosperms with diverse genera including

Euphorbia prostrata

(

E. prostrata

). Current research has provided scientific evidence for traditional uses of

E. prostrata

against diverse pathological conditions such as anti-hemorrhoidal

anti-inflammatory

analgesic

wound healing

antioxidant

antibacterial

leishmanicidal

antitumor activity

and so on. The phytochemical screening has revealed the presence of glycosides

phytosterols

flavonoids

polyphenols

tannins

and anthraquinones with chemical structures elucidation of their respective compounds. The uniqueness of such multifactorial compounds present in this species endorses it as the potent therapeutic or prophylactic choice for several fatal diseases. Although ethnomedical applications served as a significant citation for pharmacology

the molecular mechanism has not been reviewed yet. The present paper provides a comprehensive review of research outcomes

pharmacology

toxicology

and molecular signaling of phytochemicals of

E. prostrata

species as a reference for relevant researchers. The study of bioactive compounds in crude extracts and fractions

the demonstration of primary mechanisms of pharmacology

along with the addition of toxicity

and clinical trials

should be conceded in depth. This review underlines the

E. prostrata

species that can be a promising phytomedicine since we are committed to excavating more intensely into their pharmacological role.