中药靶点鉴定与机制研究所面临的挑战与前景

GUO Xiao-xi; AN Su; BAO Fan; XU Tian-rui

doi:10.1007/s11655-023-3629-9

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中药靶点鉴定与机制研究所面临的挑战与前景

Review | Updated：2023-06-27

- 中药靶点鉴定与机制研究所面临的挑战与前景
- Challenges and Perspectives in Target Identification and Mechanism Illustration for Chinese Medicine^*
- 中国结合医学杂志（英文版） 2023年29卷第7期页码：644-654
- Affiliations：
  
  1.Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming ,(650500), China
  2.The First People's Hospital of Yunnan Province, Kunming (650032), China
- Author bio：
  
  XU Tian-rui, E-mail: tianruixu@kust.edu.cn
- Funds：
  
  the National Nature Science Foundation of China(81960659;81760264;81960394);Applied Basic Research Key Project of Yunnan(202001AS070024);Yunnan Applied Basic Research Projects-Union foundation Management System(-294)
- DOI：10.1007/s11655-023-3629-9
  中图分类号：
- 纸质出版日期：2023-07，
  
  网络出版日期：2023-02-21，
  
  录用日期：2022-07-11
Scan for full text
中药靶点鉴定与机制研究所面临的挑战与前景[J]. 中国结合医学杂志（英文版）, 2023,29(7):644-654.

GUO Xiao-xi, AN Su, BAO Fan, et al. Challenges and Perspectives in Target Identification and Mechanism Illustration for Chinese Medicine^*[J]. Chinese Journal of Integrative Medicine, 2023,29(7):644-654.
中药靶点鉴定与机制研究所面临的挑战与前景[J]. 中国结合医学杂志（英文版）, 2023,29(7):644-654. DOI： 10.1007/s11655-023-3629-9.

GUO Xiao-xi, AN Su, BAO Fan, et al. Challenges and Perspectives in Target Identification and Mechanism Illustration for Chinese Medicine^*[J]. Chinese Journal of Integrative Medicine, 2023,29(7):644-654. DOI： 10.1007/s11655-023-3629-9.

摘要

中药是研究人体生命现象和新药研发的重要资源. 然而

在过去的数十年里

因为靶点不明、药理机制不清楚

中药的开发利用和国际化推广遇到了瓶颈. 中药多为复方

包涵多种活性成分

每种成分对应不同的药物靶点及其细胞信号转导通路

筛选和鉴定这些靶点并结合特定的生理病理条件

阐明主要活性成分的关键作用靶点及其分子机制是中药现代化研究面临的最大难题. 本文总结了中药来源的天然化合物的分子靶点鉴定技术和基于网络药理学的靶点预测方法. 介绍了一种以 "贝叶斯估计" 为基础的数学模型在中药复方靶点预测和关键信号通路确定中的应用. 本文旨在为基于中药活性成分的新药研发和中药国际化推广提供一些新的理论依据和研究思路.

Abstract

Chinese medicine (CM) is an important resource for human life understanding and discovery of drugs. However

due to the unclear pharmacological mechanism caused by unclear target

research and international promotion of many active components have made little progress in the past decades of years. CM is mainly composed of multi-ingredients with multi-targets. The identification of targets of multiple active components and the weight analysis of multiple targets in a specific pathological environment

that is

the determination of the most important target is the main obstacle to the mechanism clarification and thus hinders its internationalization. In this review

the main approach to target identification and network pharmacology were summarized. And BIBm (Bayesian inference modeling)

a powerful method for drug target identification and key pathway determination was introduced. We aim to provide a new scientific basis and ideas for the development and international promotion of new drugs based on CM.

关键词

中药靶点鉴定网络药物学贝叶斯估计模型

Keywords

Chinese medicinetarget identificationnetwork pharmacologyBayesian inference modeling

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