Elemene

derived from

Curcuma wenyujin

one of the "8 famous genuine medicinal materials of Zhejiang province

" exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles

specifically the "monarch

minister

assistant

and envoy" theory

with modern biomedical technology. This groundbreaking approach

along with a systematic analysis of Chinese medicine and modern biomedical knowledge

led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages

including low toxicity

well-defined composition

synergistic effects on multiple targets

and excellent biocompatibility. Following the principles of the "molecular compatibility theory"

further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms

recent clinical investigations

advancements in drug delivery systems

and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers

empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".