Efficacy of Chinese Herbal Medicines on Pregnancy Outcomes in Patients with Endometriosis in Long-Term Management: A Multicenter Retrospective Cohort Study

YANG Xin-chun; LIU Yong; SUN Wei-wei; SHI Guang; WU Ying; XU Cai; MENG Qing-wei; HAO Zeng-ping; HAN Qian; ZHAO Rui-hua

doi:10.1007/s11655-023-3736-z

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Efficacy of Chinese Herbal Medicines on Pregnancy Outcomes in Patients with Endometriosis in Long-Term Management: A Multicenter Retrospective Cohort Study

Original Article | Updated：2023-11-23

- Efficacy of Chinese Herbal Medicines on Pregnancy Outcomes in Patients with Endometriosis in Long-Term Management: A Multicenter Retrospective Cohort Study
- Efficacy of Chinese Herbal Medicines on Pregnancy Outcomes in Patients with Endometriosis in Long-Term Management: A Multicenter Retrospective Cohort Study
- 中国结合医学杂志（英文版） 2023年29卷第11期页码：971-979
- Affiliations：
  
  1.Department of Gynecology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing (100053), China
  2.Department of Traditional Chinese Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing (100026), China
  3.Department of Gynecology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing (100078), China
  4.Department of Obstetrics and Gynecology, Beijing Hospital, Beijing (100730), China
  5.Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing (100050), China
- Author bio：
  
  Prof. ZHAO Rui-hua, E-mail: rhzh801@126.com
- Funds：
  
  Capital's Funds for Health Improvement and Research(2018-1-4151);Project of "Hundred Thousand" Talents Project of TCM Inheritance and Innovation (Qihuang Project) Qihuang Scholars (Department of Human Education, National Administration of Traditional Chinese Medicine)([2018]284)
- DOI：10.1007/s11655-023-3736-z
  中图分类号：
- 纸质出版日期：2023-11，
  
  网络出版日期：2023-04-29，
  
  录用日期：2023-02-08
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Efficacy of Chinese Herbal Medicines on Pregnancy Outcomes in Patients with Endometriosis in Long-Term Management: A Multicenter Retrospective Cohort Study[J]. 中国结合医学杂志（英文版）, 2023,29(11):971-979.

YANG Xin-chun, LIU Yong, SUN Wei-wei, et al. Efficacy of Chinese Herbal Medicines on Pregnancy Outcomes in Patients with Endometriosis in Long-Term Management: A Multicenter Retrospective Cohort Study[J]. Chinese Journal of Integrative Medicine, 2023,29(11):971-979.
Efficacy of Chinese Herbal Medicines on Pregnancy Outcomes in Patients with Endometriosis in Long-Term Management: A Multicenter Retrospective Cohort Study[J]. 中国结合医学杂志（英文版）, 2023,29(11):971-979. DOI： 10.1007/s11655-023-3736-z.

YANG Xin-chun, LIU Yong, SUN Wei-wei, et al. Efficacy of Chinese Herbal Medicines on Pregnancy Outcomes in Patients with Endometriosis in Long-Term Management: A Multicenter Retrospective Cohort Study[J]. Chinese Journal of Integrative Medicine, 2023,29(11):971-979. DOI： 10.1007/s11655-023-3736-z.

摘要

Abstract

Objective:

To analyze the factors related to pregnancy of endometriosis and whether Chinese herbal medicines (CHMs) can improve pregnancy outcomes in patients with endometriosis in long-term management.

Methods:

This multicenter cohort study retrospectively analyzed the clinical data of endometriosis patients with fertility needs from January 2019 to November 2019. A total of 252 patients with endometriosis from 5 level-Ⅲ Grade A hospitals in Beijing were included in this study. Univariate and multivariate logistic regression analysis were performed for the relevant factors. The propensity score matching (PSM) function of SPSS software was used to match the CHMs group with the non-CHMs group. The pregnancy rate and live birth rate were analyzed.

Results:

The results of univariate analysis showed that age

disease course

presence of infertility

presence of adenomyosis

time after surgery or use of gonadotropin-releasing hormone agonist (GnRH-a)

use of CHMs and follow-up time were influencing factors of pregnancy in endometriosis patients (

0.05). The results of multivariate analysis showed that age

presence of adenomyosis

time after surgery or use of GnRH-a

use of CHMs and follow-up time were independent factors affecting pregnancy in endometriosis patients

among which

age 35 years old

presence of adenomyosis and follow-up time

6 months were independent risk factors (OR=0.445

0.348

0.140

respectively

0.05)

time after surgery or use of GnRH-a 6 months and use of CHMs were independent protective factors (OR=3.839

3.842

respectively

0.05) . After PSM

99 pairs of two groups were matched successfully. The pregnancy rate of the CHMs group was higher than that of the non-CHMs group [55.56% (55/99)

. 36.36% (36/99)

0.05]. The live birth rate of the CHMs group was higher than that of the non-CHMs group [49.49% (49/99)

. 35.35% (35/99)

0.05].

Conclusion:

CHMs can effectively improve clinical pregnancy rate and live birth rate of patients with endometriosis in the chronic disease management.

关键词

Keywords

endometriosispregnancyChinese herbal medicinemultivariate analysisretrospective cohort studylong-term management

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