NLRP3炎症小体介导的细胞焦亡对心血管疾病的影响及中药的干预机制

ZHONG Yi; LI Xin-yue; LIANG Tian-jun; DING Bao-zhu; MA Ke-xin; REN Wen-xuan; LIANG Wen-jie

doi:10.1007/s11655-024-3655-2

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NLRP3炎症小体介导的细胞焦亡对心血管疾病的影响及中药的干预机制

Review | Updated：2024-04-23

- NLRP3炎症小体介导的细胞焦亡对心血管疾病的影响及中药的干预机制
- Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine
- 中国结合医学杂志（英文版） 2024年30卷第5期页码：468-479
- Affiliations：
  
  1.College of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney Diseases, Institute of Integrated Traditional Chinese and Western Medicine, Shijiazhuang(050200), China
  2.Department of Cardiovascular Internal Medicine, the Second Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi Province (332000), China
  3.Graduate School,Hebei Medical University, Shijiazhuang (050017), China
  4.Rural Physician College, Hebei Medical University, Shijiazhuang(050017), China
  5.Medical Department, the First Hospital of Hebei Medical University, Shijiazhuang (050030), China
- Author bio：
  
  Prof. LIANG Wen-jie, E-mail: lwj712004@163.com
- Funds：
  
  the Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine(2020149)
- DOI：10.1007/s11655-024-3655-2
  中图分类号：
- 纸质出版日期：2024-05，
  
  网络出版日期：2024-02-08，
  
  录用日期：2023-10-13
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NLRP3炎症小体介导的细胞焦亡对心血管疾病的影响及中药的干预机制[J]. 中国结合医学杂志（英文版）, 2024,30(5):468-479.

ZHONG Yi, LI Xin-yue, LIANG Tian-jun, et al. Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine[J]. Chinese Journal of Integrative Medicine, 2024,30(5):468-479.
NLRP3炎症小体介导的细胞焦亡对心血管疾病的影响及中药的干预机制[J]. 中国结合医学杂志（英文版）, 2024,30(5):468-479. DOI： 10.1007/s11655-024-3655-2.

ZHONG Yi, LI Xin-yue, LIANG Tian-jun, et al. Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine[J]. Chinese Journal of Integrative Medicine, 2024,30(5):468-479. DOI： 10.1007/s11655-024-3655-2.

摘要

NOD样受体蛋白3 (NLRP3) 炎症小体信号通路活化是心肌细胞焦亡的重要机制

并在糖尿病心肌病、缺血/再灌注、心肌梗死、心力衰竭、高血压病等心血管疾病 (CVD) 心肌组织炎症损伤中发挥重要作用

非编码RNA (ncRNA) 是重要的调节因子. 许多中药复方或有效成分可调控细胞焦亡

发挥心肌保护作用

其机制包括抑制炎症小体表达、抑制Toll样受体4-NF-κB信号通路、抑制氧化应激、抑制内质网应激、抑制混合谱系激酶3、调控沉默信息调节因子1等. NLRP3分子是中药防治CVD的重要调控靶点

探索中医药的干预作用及机制将为CVD防治提供新的思路与视角.

Abstract

Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases (CVDs)

such as diabetic cardiomyopathy

ischemia/reperfusion injury

myocardial infarction

heart failure and hypertension. Noncoding RNAs (ncRNAs) are important regulatory factors. Many Chinese medicine (CM) compounds

including their effective components

can regulate pyroptosis and exert myocardium-protecting effects. The mechanisms underlying this protection include inhibition of inflammasome protein expression

Toll-like receptor 4–NF-κB signal pathway activation

oxidative stress

endoplasmic reticulum stress (ERS)

and mixed lineage kinase 3 expression and the regulation of silent information regulator 1. The NLRP3 protein is an important regulatory target for CVD prevention and treatment with CM. Exploring the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关键词

细胞焦亡心血管疾病中药NLRP3机制

Keywords

pyroptosiscardiovascular diseasesChinese medicineNOD-like receptor protein 3mechanisms

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