芳香疗法对放化疗后肿瘤患者影响的荟萃分析

XIE Shuang-ran; MA Liang; XU Xin-yu; ZHOU Shu; XIE Hui-miao; XIE Chang-sheng

doi:10.1007/s11655-024-3659-y

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芳香疗法对放化疗后肿瘤患者影响的荟萃分析

Evidence-Based Integrative Medicine | Updated：2024-04-23

- 芳香疗法对放化疗后肿瘤患者影响的荟萃分析
- Effects of Aromatherapy on Physical and Mental Health of Cancer Patients Undergoing Radiotherapy and/or Chemotherapy: A Meta-Analysis
- 中国结合医学杂志（英文版） 2024年30卷第5期页码：449-457
- Affiliations：
  
  1.The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou (310053), China
  2.Department of Medical Oncology, Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou (310007), China
  3.Department of Dermatology, the Third Xiangya Hospital, Central South University, Changsha(410013), China
  4.Department of Famous Chinese Medicine Clinic, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou (310005), China
  5.Department of Medical Oncology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou (310006), China
- Author bio：
  
  Prof. XIE Chang-sheng, E-mail: xiecslq@126.com
- Funds：
  
  National College Student Innovation and Entrepreneurship Training Program(202210344031)
- DOI：10.1007/s11655-024-3659-y
  中图分类号：
- 纸质出版日期：2024-05，
  
  网络出版日期：2024-03-15，
  
  录用日期：2024-01-03
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芳香疗法对放化疗后肿瘤患者影响的荟萃分析[J]. 中国结合医学杂志（英文版）, 2024,30(5):449-457.

XIE Shuang-ran, MA Liang, XU Xin-yu, et al. Effects of Aromatherapy on Physical and Mental Health of Cancer Patients Undergoing Radiotherapy and/or Chemotherapy: A Meta-Analysis[J]. Chinese Journal of Integrative Medicine, 2024,30(5):449-457.
芳香疗法对放化疗后肿瘤患者影响的荟萃分析[J]. 中国结合医学杂志（英文版）, 2024,30(5):449-457. DOI： 10.1007/s11655-024-3659-y.

XIE Shuang-ran, MA Liang, XU Xin-yu, et al. Effects of Aromatherapy on Physical and Mental Health of Cancer Patients Undergoing Radiotherapy and/or Chemotherapy: A Meta-Analysis[J]. Chinese Journal of Integrative Medicine, 2024,30(5):449-457. DOI： 10.1007/s11655-024-3659-y.

摘要

背景:

目前

芳香疗法被广泛应用于临床实践中

尤其在治疗接受放化疗后的肿瘤患者中备受关注. 然而

芳香疗法的实际疗效仍有待深入探讨. 目的: 本研究旨在探讨芳香疗法对放化疗后的肿瘤患者身心健康的影响.

方法:

本研究系统检索PubMed、Scopus、Web of Science、中国知网、万方数据库、中国生物医学文献数据库、维普网从建库至2023年9月29日发表的文献. 数据分析采用ReviewManager5.3版本进行

并运用Cochrane的偏倚风险工具RoB2评估纳入研究的文献质量. 通过GRADEproGDT在线工具

采用GRADE方法评估证据质量等级.

结果:

本研究共纳入19项研究

涉及1541名患者. 结果显示: 芳香疗法可缓解恶心[相对危险度 (RR) =0.64

95%置信区间 (CI) : 0.53至0.78

0.05

=46%; 标准化平均差 (SMD) =-0.86

95%CI: -1.21至-0.51

0.05

=64%]和呕吐 (RR=0.54

95%CI: 0.42至0.69

0.05

=35%; SMD=-1.28

95%CI: -1.52至-1.03

0.05

=92%)

改善睡眠障碍 (平均差 (MD) =-3.39

95%CI: -3.95至-2.84

0.05

=0%)

减轻疼痛 (SMD=-1.58

95%置信区间CI: -1.96至-1.21

0.05

=0%)

减缓疲劳 (SMD=-1.28

95%置信区间CI: -2.44至-0.11

0.05

=93%)

提高生活质量 (SMD=0.50

95%置信区间CI: 0.22至0.79

0.05

=0%)

然而对焦虑改善的效果尚不明确. 在应用Cochrane风险偏倚工具RoB2后

我们发现纳入研究存在较高的偏倚风险. 根据GRADE方法评估

所有研究的证据质量评分较低.

结论:

对肿瘤患者来说

芳香疗法是一种有效、安全且经济的辅助疗法

可改善其身心健康. 但仍需要更多高质量的研究来验证这一结论. (PROSPERO注册号: No.CRD42023390171)

Abstract

Backgroup:

Currently

aromatherapy is being increasingly utilized in clinical practice

particularly in managing the side effects associated with radiotherapy and chemoradiotherapy. However

it remains to be established whether aromatherapy can effectively alleviate these symptoms.

Objective:

To investigate the effects of aromatherapy on the physical and mental health of patients with cancer undergoing radiotherapy and chemotherapy.

Methods:

Seven databases were researched from inception until September 29

2023

including PubMed

Scopus

and Web of Science

Chinese National Knowledge Infrastructure

Wanfang database

China Biology Medicine disc and VIP Chinese Medical Journal Database. Review Manager version 5.3 was utilized for data analysis. The Cochrane Risk of Bias tool RoB2 was employed to evaluate the quality of the literature included in the study. Evidence quality rating was assessed using the Grading of Recommendations Assessment

Development

and Evaluation (GRADE) approach through the GRADEpro GDT online tool.

Results:

Nineteen studies involving 1

541 patients were included. Aromatherapy can alleviate nausea [relative risk (RR)=0.64

95% confidence interval (CI): 0.53 to 0.78

0.05

=46%; standardized mean difference (SMD)=–0.86

95% CI: –1.21 to –0.51

0.05

=64%] and vomiting (RR=0.54

95% CI: 0.42 to 0.69

0.05

=35%; SMD=–1.28

95% CI: –1.52 to –1.03

0.05

=92%)

improve sleep disorders [mean difference (MD)=–3.39

95% CI: –3.95 to –2.84

0.05

=0%]

relieve pain (SMD=–1.58

95% CI: –1.96 to –1.21

0.05

=0%)

mitigate fatigue (SMD=–1.28

95% CI: –2.44 to –0.11

0.05

=93%) and enhance quality of life (SMD=0.50

95% CI: 0.22 to 0.79

0.05

=0%) in cancer patients after radiotherapy and chemotherapy

but it may not have a significant effect on anxiety. The risk of bias was high in the included studies using the Cochrane Risk of Bias tool RoB2

and no studies were considered to be of high grade according to the GRADE system.

Conclusions:

Aromatherapy is an efficacious

safe and economic adjunctive therapy for cancer patients

which can mend the physical symptoms and mental health of cancer patients. However

more high-quality studies are needed to verify it. (PROSPERO registration No. CRD42023390171)

关键词

芳香疗法癌症放化疗生理心理

Keywords

aromatherapycancerchemoradiotherapyphysicalpsychological

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