Objective:

2

To establish the dynamic treatment strategy of Chinese medicine (CM) for metastatic colorectal cancer (mCRC) by machine learning algorithm

in order to provide a reference for the selection of CM treatment strategies for mCRC.

Methods:

2

From the outpatient cases of mCRC in the Department of Oncology at Xiyuan Hospital

China Academy of Chinese Medical Sciences

197 cases that met the inclusion criteria were screened. According to different CM intervention strategies

the patients were divided into 3 groups: CM treatment alone

equal emphasis on Chinese and Western medicine treatment (CM combined with local treatment of tumors

oral chemotherapy

or targeted drugs)

and CM assisted Western medicine treatment (CM combined with intravenous regimen of Western medicine). The survival time of patients undergoing CM intervention was taken as the final evaluation index. Factors affecting the choice of CM intervention scheme were screened as decision variables. The dynamic CM intervention and treatment strategy for mCRC was explored based on the cost-sensitive classification learning algorithm for survival (CSCLSurv). Patients' survival was estimated using the Kaplan-Meier method

and the survival time of patients who received the model-recommended treatment plan were compared with those who received actual treatment plan.

Results:

2

Using the survival time of patients undergoing CM intervention as the evaluation index

a dynamic CM intervention therapy strategy for mCRC was established based on CSCLSurv. Different CM intervention strategies for mCRC can be selected according to dynamic decision variables

such as gender

age

Eastern Cooperative Oncology Group score

tumor site

metastatic site

genotyping

and the stage of Western medicine treatment at the patient's first visit. The median survival time of patients who received the model-recommended treatment plan was 35 months

while those who receive the actual treatment plan was 26.0 months (

P

=0.06).

Conclusions:

2

The dynamic treatment strategy of CM

based on CSCLSurv for mCRC

plays a certain role in providing clinical hints in CM. It can be further improved in future prospective studies with larger sample sizes.