Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review

ZHU Bo-yu; LIU Zhi-chao; ZHAO Zhen-xi; HUANG Hui-ping; ZHANG Na; XIA Jia; CHEN Wei-wei

doi:10.1007/s11655-024-3762-0

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Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review

Review | Updated：2025-01-21

- Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review
- Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review
- 中国结合医学杂志（英文版） 2025年31卷第2期页码：157-169
- Affiliations：
  
  Department of Rheumatology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai (200071), China
- Author bio：
  
  Prof. CHEN Wei-wei, E-mail: chenweiwei@shutcm.edu.cn
- Funds：
  
  National Natural Science Foundation of China(81603563);Shanghai Collaborative Innovation Center of Industrial Transformation of Hospital TCM Preparation(801B1);Traditional Chinese Medicine Science and Technology Development Project of Shanghai Medical Innovation & Development Foundation(WL-YJXYS-2021005K;WLJH2021ZY-MZY037)
- DOI：10.1007/s11655-024-3762-0
  中图分类号：
- 纸质出版日期：2025-02，
  
  网络出版日期：2024-09-05，
  
  录用日期：2024-06-24
- Accepted：
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Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review[J]. 中国结合医学杂志（英文版）, 2025,31(2):157-169.

ZHU BO-YU, LIU ZHI-CHAO, ZHAO ZHEN-XI, et al. Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review. [J]. Chinese journal of integrative medicine, 2025, 31(2): 157-169.
Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review[J]. 中国结合医学杂志（英文版）, 2025,31(2):157-169. DOI： 10.1007/s11655-024-3762-0.

ZHU BO-YU, LIU ZHI-CHAO, ZHAO ZHEN-XI, et al. Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review. [J]. Chinese journal of integrative medicine, 2025, 31(2): 157-169. DOI： 10.1007/s11655-024-3762-0.

摘要

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder affecting multiple systems

characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and tissues. Chinese medicine (CM) plays a role in mitigating complications

enhancing treatment effectiveness

and reducing toxicity of concurrent medications

and ensuring a safe pregnancy. However

CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process

therefore

its treatment mechanism is often complicated

involving many molecular links. This review introduces the research progress of pathogenesis of SLE from the aspects of genetics

epigenetics

innate immunity and acquired immunity

and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLE.

关键词

Keywords

systemic lupus erythematosusChinese medicinenatural extractstreatmentreview

references

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