类风湿关节炎预防的治疗窗口

REN Qun-li; LI Xiao-lan; TIAN Tian; LI Shuang; SHI Rong-yi; WANG Qian; ZHU Yuan; WANG Miao; HU Huan; LIU Jian-guo

doi:10.1007/s11655-024-3804-7

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类风湿关节炎预防的治疗窗口

Review | Updated：2024-08-24

- 类风湿关节炎预防的治疗窗口
- Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma
- 中国结合医学杂志（英文版） 2024年30卷第9期页码：852-864
- Affiliations：
  
  1.School of Stomatology, Zunyi Medical University, Zunyi, Guizhou Province (563000), China
  2.Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Zunyi Medical University, Zunyi, Guizhou Province (563000), China
  3.School of Basic Medicine, Zunyi Medical University, Zunyi, Guizhou Province (563000), China
- Author bio：
  
  Prof. LIU Jian-guo, E-mail: 13087891001@163.com
- Funds：
  
  National and Provincial First-Class Undergraduate Major Construction Point for 2020–Stomatology Major of Guizhou Province(QJH (2021) 28);the Zunyi Innovative Talent Team of Oral Diseases Immunity and Medical Biomaterials Research(ZSRC (2022) 1);the Science and Technology Project of Zunyi(ZSKH-HZ (2020) 60);the Special Project of Zunyi Medical University for Academic New Talents(QKHPT (2018) 5772-067);the Training Program Project of Zunyi Medical University for 2022 National and Provincial College Students Innovation and Entrepreneurship(S202210661227);the Training Program Project of Zunyi Medical University for Tutor Tendering Type College Students Innovation and Entrepreneurship(ZYDC2022042)
- DOI：10.1007/s11655-024-3804-7
  中图分类号：
- 纸质出版日期：2024-09，
  
  网络出版日期：2024-04-12，
  
  录用日期：2023-12-18
- Accepted：
Scan for full text
类风湿关节炎预防的治疗窗口[J]. 中国结合医学杂志（英文版）, 2024,30(9):852-864.

REN Qun-li, LI Xiao-lan, TIAN Tian, et al. Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma[J]. Chinese Journal of Integrative Medicine, 2024,30(9):852-864.
类风湿关节炎预防的治疗窗口[J]. 中国结合医学杂志（英文版）, 2024,30(9):852-864. DOI： 10.1007/s11655-024-3804-7.

REN Qun-li, LI Xiao-lan, TIAN Tian, et al. Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma[J]. Chinese Journal of Integrative Medicine, 2024,30(9):852-864. DOI： 10.1007/s11655-024-3804-7.

摘要

类风湿性关节炎 (RA) 是一个全球性公共健康问题. 延缓或预防RA的干预措施近年来备受关注

研究人员正在探索各种RA预防策略. 目前

对于RA预防仍没有统一共识

但针对高危人群的治疗窗口期实施干预措施是非常重要的. 由于药物干预的临床试验数量有限

需要进一步的研究来寻找和建立最佳干预方案和有效措施来防止RA的发展. 本综述介绍了RA的发病过程和危险因素

并从临床角度描述了中西医结合预防RA的研究进展. 此外

我们还介绍了几个使用中药复方预防RA的临床研究.

Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignant cancer of the head and neck

with high morbidity and mortality

ranking as the sixth most common cancer in the world. The treatment of OSCC is mainly radiotherapy

chemotherapy and surgery

however

the prognosis of patients is still poor and the recurrence rate is high. This paper reviews the range of effects of natural medicinal plant active ingredients (NMPAIs) on OSCC cancer

including the types of NMPAIs

anti-cancer mechanisms

involved signaling pathways

and clinical trials. The NMPAIs include terpenoids

phenols

flavonoids

glycosides

alkaloids

coumarins

and volatile oils. These active ingredients inhibit proliferation

induce apoptosis and autophagy

inhibit migration and invasion of OSCC cells

and regulate cancer immunity to exert anti-cancer effects. The mechanism involves signaling pathways such as mitogen-activated protein kinase

phosphatidylinositol 3 kinase/protein kinase B

nuclear factor kappa B

miR-22/WNT1/β-catenin and Nrf2/Keap1. Clinically

NMPAIs can inhibit the growth of OSCC

and the combined drug is more effective. Natural medicinal plants are promising candidates for the treatment of OSCC.

关键词

Keywords

natural medicinal plantactive ingredientsoral squamous cell carcinomamechanismsignaling pathwayreview

references

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