Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway<sup>*</sup>

LONG Lin-zi; TAN Ling; XU Feng-qin; YANG Wen-wen; LI Hong-zheng; LIU Jian-gang; WANG Ke; ZHAO Zhi-ru; WANG Yue-qi; WANG Chao-ju; WEN Yi-chao; HUANG Ming-yan; QU Hua; FU Chang-geng; CHEN Ke-ji

doi:10.1007/s11655-024-3807-4

Your Location：

Home >

Browse articles >

Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway^*

Original Article | Updated：2025-04-22

- Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway^*
- Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway^*
- 中国结合医学杂志（英文版） 2025年31卷第5期页码：402-411
- Affiliations：
  
  1.Department of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing (100091), China
  2.Department of Traditional Chinese Medicine, the Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen (518033), Guangdong Province, China
  3.Xiyuan Hospital, National Cardiovascular Clinical Medical Research Center of Traditional Medicine, Beijing (100091), China
  4.Graduate School of Beijing University of Chinese Medicine, Beijing (100091), China
  5.Cardiovascular Department, the Second Affiliated Hospital, Shanxi University of Chinese Medicine, Taiyuan (030002), China
  6.Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing (100090), China
  7.Cadre 2 Ward, Xinjiang Uygur Autonomous Region Institute of Traditional Chinese Medicine, Urumqi (830000), China
  8.Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou (350122), China
- Author bio：
  
  Dr. FU Chang-geng, E-mail: fucgbs@163.com
- Funds：
  
  Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01C556);National Natural Science Foundation of China(82104678);Science and Technology Innovation Project of China Academy of Chinese Medical Sciences(CI2021A05013)
- DOI：10.1007/s11655-024-3807-4
  中图分类号：
- 录用日期：2024-01-31，
  
  网络出版日期：2024-09-07，
  
  纸质出版日期：2025-05
- Accepted：
Scan QR Code
Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway^*[J]. 中国结合医学杂志（英文版）, 2025,31(5):402-411.

LONG Lin-zi, TAN Ling, XU Feng-qin, et al. Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway^*[J]. Chinese journal of integrative medicine, 2025, 31(5): 402-411.
Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway^*[J]. 中国结合医学杂志（英文版）, 2025,31(5):402-411. DOI： 10.1007/s11655-024-3807-4.

LONG Lin-zi, TAN Ling, XU Feng-qin, et al. Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway^*[J]. Chinese journal of integrative medicine, 2025, 31(5): 402-411. DOI： 10.1007/s11655-024-3807-4.

摘要

Abstract

Objective:

To assess the efficacy of Qingda Granule (QDG) in ameliorating hypertension-induced cardiac damage and investigate the underlying mechanisms involved.

Methods:

Twenty spontaneously hypertensive rats (SHRs) were used to develope a hypertension-induced cardiac damage model. Another 10 Wistar Kyoto (WKY) rats were used as normotension group. Rats were administrated intragastrically QDG [0.9 g/(kg•d)] or an equivalent volume of pure water for 8 weeks. Blood pressure

histopathological changes

cardiac function

levels of oxidative stress and inflammatory response markers were measured. Furthermore

to gain insights into the potential mechanisms underlying the protective effects of QDG against hypertension-induced cardiac injury

a network pharmacology study was conducted. Predicted results were validated by Western blot

radioimmunoassay immunohistochemistry and quantitative polymerase chain reaction

respectively.

Results:

The administration of QDG resulted in a significant decrease in blood pressure levels in SHRs (

0.01). Histological examinations

including hematoxylin-eosin staining and Masson trichrome staining revealed that QDG effectively attenuated hypertension-induced cardiac damage. Furthermore

echocardiography demonstrated that QDG improved hypertension-associated cardiac dysfunction. Enzyme-linked immunosorbent assay and colorimetric method indicated that QDG significantly reduced oxidative stress and inflammatory response levels in both myocardial tissue and serum (

0.01).

Conclusion:

Both network pharmacology and experimental investigations confirmed that QDG exerted its beneficial effects in decreasing hypertension-induced cardiac damage by regulating the angiotensin converting enzyme (ACE)/angiotensin Ⅱ (Ang Ⅱ)/Ang Ⅱ receptor type 1 axis and ACE/Ang Ⅱ/Ang Ⅱreceptor type 2 axis.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Electroacupuncture Attenuated Phenotype Transformation of Vascular Smooth Muscle Cells via PI3K/Akt and MAPK Signaling Pathways in Spontaneous Hypertensive Rats

Identification of Hypertension Subgroups through Topological Analysis of Symptom-Based Patient Similarity

Effect of Shexiang Baoxin Pill (麝香保心丸) in Alleviating Early Hypertensive Renal Injury in Rats

Study on the Intervention Effects of Pinggan Prescription (平肝方) on Spontaneously Hypertensive Rats Based on Metabonomic and Pharmacodynamic Methods

Blood-Letting Therapy for Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials