Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine<sup>*</sup>

GAO Lei; LI Yun-jia; ZHAO Jia-min; LIAO Yu-xin; QIN Meng-chen; LI Jun-jie; SHI Hao; Wong Nai-Kei; LYU Zhi-ping; SHEN Jian-gang

doi:10.1007/s11655-024-3810-9

Your Location：

Home >

Browse articles >

Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*

Review | Updated：2025-04-22

- Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*
- Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*
- 中国结合医学杂志（英文版） 2025年31卷第5期页码：462-473
- Affiliations：
  
  1.School of Traditional Chinese Medicine, Southern Medical University, Guangzhou (510515), China
  2.The First Affiliated Hospital/the First Clinical Medicine School of Guangdong Pharmaceutical University, Guangzhou (510006), China
  3.State Key Discipline of Infectious Diseases, Shenzhen Third People's Hospital, the Second Affiliated Hospital, Shenzhen University, Shenzhen (518112), Guangdong Province, China
  4.School of Chinese Medicine, the University of Hong Kong, Hong Kong SAR, China
- Author bio：
  
  Prof. SHEN Jian-gang, E-mail: shenjg@hku.hk
- Funds：
  
  the National Natural Science Foundation of China(82074131;82374270);Guangzhou Basic and Applied Basic Research Foundation(SL2023A03J01172);the Outstanding Youth Development Scheme Project of Southern Medical University(G621299870);Young Elite Scientists Sponsorship Program by CACM(2021-QNRC2-B28)
- DOI：10.1007/s11655-024-3810-9
  中图分类号：
- 录用日期：2024-03-04，
  
  网络出版日期：2024-06-28，
  
  纸质出版日期：2025-05
- Accepted：
Scan QR Code
Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*[J]. 中国结合医学杂志（英文版）, 2025,31(5):462-473.

GAO Lei, LI Yun-jia, ZHAO Jia-min, et al. Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*[J]. Chinese journal of integrative medicine, 2025, 31(5): 462-473.
Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*[J]. 中国结合医学杂志（英文版）, 2025,31(5):462-473. DOI： 10.1007/s11655-024-3810-9.

GAO Lei, LI Yun-jia, ZHAO Jia-min, et al. Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine^*[J]. Chinese journal of integrative medicine, 2025, 31(5): 462-473. DOI： 10.1007/s11655-024-3810-9.

摘要

Abstract

Liver ischemia-reperfusion injury (LIRI) is a pathological process involving multiple injury factors and cell types

with different stages. Currently

protective drugs targeting a single condition are limited in efficacy

and interventions on immune cells will also be accompanied by a series of side effects. In the current bottleneck research stage

the multi-target and obvious clinical efficacy of Chinese medicine (CM) is expected to become a breakthrough point in the research and development of new drugs. In this review

we summarize the roles of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in various stages of hepatic ischemia-reperfusion and on various types of cells. Combined with the current research progress in reducing ROS/RNS with CM

new therapies and mechanisms for the treatment of hepatic ischemia-reperfusion are discussed.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Mechanism of Astragaloside Ⅳ in Treatment of Renal Tubulointerstitial Fibrosis^*

Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review

Research Progress of Chinese Medicine Monomers in Treatment of Cholangiocarcinoma

Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

Progress on Regulation of NLRP3 Inflammasome by Chinese Medicine in Treatment of Ulcerative Colitis