<italic style="font-style: italic">Morchella conica</italic>, <italic style="font-style: italic">Morchella esculenta</italic> and <italic style="font-style: italic">Morchella delicosa</italic> Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation

Faiz Ul Haq; Muhammad Imran; Sami Ullah; Usman Aftab; Tasleem Akhtar; Asif Haleem Khan; Roh Ullah; Hasan Ejaz; Fatema Gaffar; Imad Khan

doi:10.1007/s11655-024-3819-0

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Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation

Original Article | Updated：2025-09-23

- Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation
- Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation
- 中国结合医学杂志（英文版） 2025年31卷第10期页码：918-927
- Affiliations：
  
  1.Department of Microbiology, University of Health Sciences, Lahore (54600), Pakistan
  2.Department of Forensic Sciences, University of Health Sciences, Lahore (54600), Pakistan
  3.Department of Pharmacology, University of Health Sciences, Lahore (54600), Pakistan
  4.Department of Hematology, University of Health Sciences, Lahore (54600), Pakistan
  5.Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka (72388), Saudi Arabia
  6.Institute of Allied Health Sciences, De Montfort University, Leicester (LE1 9BH), UK
  7.State Key Laboratory of Food Science and Resources, National Engineering Research Center for Functional Food, National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, WuxiJiangsu Province (214122), China
- Author bio：
  
  Dr. Muhammad Imran, E-mail: mi.bannu@yahoo.com
- Funds：
- DOI：10.1007/s11655-024-3819-0
  中图分类号：
- 录用日期：2024-06-26，
  
  网络出版日期：2024-09-03，
  
  纸质出版日期：2025-10
- Accepted：
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Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation[J]. 中国结合医学杂志（英文版）, 2025,31(10):918-927.

Faiz Ul Haq, Muhammad Imran, Sami Ullah, et al. Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation[J]. Chinese journal of integrative medicine, 2025, 31(10): 918-927.
Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation[J]. 中国结合医学杂志（英文版）, 2025,31(10):918-927. DOI： 10.1007/s11655-024-3819-0.

Faiz Ul Haq, Muhammad Imran, Sami Ullah, et al. Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation[J]. Chinese journal of integrative medicine, 2025, 31(10): 918-927. DOI： 10.1007/s11655-024-3819-0.

摘要

Abstract

Objective:

To explore the potential apoptotic mechanisms of 3

Morchella

extracts (

Morchella conica

Morchella esculenta

and

Morchella delicosa

) on breast and colon cancer cell lines using apoptotic biomarkers.

Methods:

Human breast cell line (MCF-7) and colon cancer cell line (SW-480) were treated with methanol and ethanol extracts of 3

Morchella

species with concentration ranging from 0.0625 to 2 mg/mL. After that their effects on gene expression of apoptosis related markers (pro-apoptotic markers including Bax

caspase-3

caspase-7

and caspase-9

and the antiapoptotic marker including Bcl-2) were determined using reverse transcription polymerase chain reaction.

Results:

All

Morchella

extracts reduced breast and colon cancer cells proliferation at half inhibitory concentration (IC

) of 0.02±0.01 to 0.68±0.30 mg/mL. As expected

all

Morchella

extr

acts significantly increased gene expressions of Bax

caspase-3

caspase-7

and caspase-9 and downregulated the gene expression of Bcl-2 in MCF-7 and SW-480 cell lines (

0.05).

Conclusions:

Morchella

extracts demonstrated significant anti-proliferative activity against breast and colon cancer cell lines via an apoptosis induction mechanism. Anticancer activity of

Morchella

extracts and activation of apoptosis in breast and colon cancer cells suggest that it may be used to develop chemotherapeutic agents against cancer in future.

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Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation

Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation

DOI：10.1007/s11655-024-3819-0

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Abstract

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Keywords

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