基于海马的神经可塑性探讨中药逍遥散抗抑郁的作用

ZHANG Wu-jing; GUO Ze-xuan; WANG Yi-di; FANG Shao-yi; WAN Chun-miao; YU Xiao-long; GUO Xiao-fang; CHEN Yue-yue; ZHOU Xuan; HUANG Jun-qing; LI Xiao-juan; CHEN Jia-xu; FAN Li-li

doi:10.1007/s11655-024-3908-0

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基于海马的神经可塑性探讨中药逍遥散抗抑郁的作用

Review | Updated：2024-07-22

- 基于海马的神经可塑性探讨中药逍遥散抗抑郁的作用
- From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine Xiaoyaosan
- 中国结合医学杂志（英文版） 2024年30卷第8期页码：747-758
- Affiliations：
  
  Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Jinan University, Guangzhou (510632), China
- Author bio：
  
  Dr. FAN Li-li, E-mail: fanlili@jnu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82304746);Jinan University Innovation and Entrepreneurship Training Program for Undergraduate(CX21255;CX22481)
- DOI：10.1007/s11655-024-3908-0
  中图分类号：
- 纸质出版日期：2024-08，
  
  网络出版日期：2024-06-20，
  
  录用日期：2023-09-22
- Accepted：
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基于海马的神经可塑性探讨中药逍遥散抗抑郁的作用[J]. 中国结合医学杂志（英文版）, 2024,30(8):747-758.

ZHANG Wu-jing, GUO Ze-xuan, WANG Yi-di, et al. From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine Xiaoyaosan[J]. Chinese Journal of Integrative Medicine, 2024,30(8):747-758.
基于海马的神经可塑性探讨中药逍遥散抗抑郁的作用[J]. 中国结合医学杂志（英文版）, 2024,30(8):747-758. DOI： 10.1007/s11655-024-3908-0.

ZHANG Wu-jing, GUO Ze-xuan, WANG Yi-di, et al. From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine Xiaoyaosan[J]. Chinese Journal of Integrative Medicine, 2024,30(8):747-758. DOI： 10.1007/s11655-024-3908-0.

摘要

海马体是抑郁症中最常被研究的大脑区域之一. 抑郁症患者海马体积明显减少

严重破坏海马神经可塑性. 然而

靶向海马神经可塑性的抗抑郁疗法尚未明确. 中药可能通过调节海马神经可塑性来减缓抑郁症的进展. 逍遥散

功用疏肝健脾

临床上常被用来治疗抑郁症

其机制可能与调节海马神经可塑性有关. 本文综述了抑郁症与海马神经可塑性异常的关系. 此外

我们还对近30年来发表的关于逍遥散对海马神经可塑性影响的研究进行了总结

以阐明其治疗抑郁症的可能机制

可为今后逍遥散治疗抑郁症的研究提供参考.

Abstract

The hippocampus is one of the most commonly studied brain regions in the context of depression. The volume of the hippocampus is significantly reduced in patients with depression

which severely disrupts hippocampal neuroplasticity. However

antidepressant therapies that target hippocampal neuroplasticity have not been identified as yet. Chinese medicine (CM) can slow the progression of depression

potentially by modulating hippocampal neuroplasticity. Xiaoyaosan (XYS) is a CM formula that has been clinically used for the treatment of depression. It is known to protect Gan (Liver) and Pi (Spleen) function

and may exert its antidepressant effects by regulating hippocampal neuroplasticity. In this review

we have summarized the association between depression and aberrant hippocampal neuroplasticity. Furthermore

we have discussed the researches published in the last 30 years on the effects of XYS on hippocampal neuroplasticity in order to elucidate the possible mechanisms underlying its therapeutic action against depression. The results of this review can aid future research on XYS for the treatment of depression.

关键词

抑郁海马神经可塑性逍遥散中药

Keywords

depressionhippocampal neuroplasticityXiaoyaosanChinese medicine

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