Effectiveness and Safety of Auricular Acupressure Combined with Periocular Thumbtack Needle Therapy for Premyopic Children: A Multicenter, Randomized, Controlled Trial

HOU Xin-yue; LI Bao-hua; WANG Jian-quan; YANG Ying-xin; YAO Xiao-ping; ZHANG Feng-mei; YAO Jing; YU Jing-sheng; LIU Xin-quan; LIANG Feng-ming; YU Xiao-yi; SONG Man; SHANG Yu-hui; KANG Ze-feng

doi:10.1007/s11655-025-3820-2

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Effectiveness and Safety of Auricular Acupressure Combined with Periocular Thumbtack Needle Therapy for Premyopic Children: A Multicenter, Randomized, Controlled Trial

Acupuncture Research | Updated：2026-08-04

- Effectiveness and Safety of Auricular Acupressure Combined with Periocular Thumbtack Needle Therapy for Premyopic Children: A Multicenter, Randomized, Controlled Trial
- Effectiveness and Safety of Auricular Acupressure Combined with Periocular Thumbtack Needle Therapy for Premyopic Children: A Multicenter, Randomized, Controlled Trial
- Chinese Journal of Integrative Medicine 2026年32卷第3期页码：258-266
- Affiliations：
  
  1.Department of Ophthalmology, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing (100040), China
  2.Department of Ophthalmology, Beijing Hospital of Traditional Chinese Medicine, Beijing (100029), China
  3.Department of Ophthalmology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong Province (518000), China
  4.Department of Ophthalmology, Henan Province Hospital of Traditional Chinese Medicine, the Secord Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou (450003), China
  5.Department of Ophthalmology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin (150040), China
  6.Department of Ophthalmology, the First Hospital of Hunan University of Chinese Medicine, Changsha (410036), China
  7.Department of Ophthalmology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai (200032), China
  8.Department of Ophthalmology, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin (300381), China
  9.Department of Ophthalmology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou (510405), China
  10.Department of Ophthalmology, Fuzhou Traditional Chinese Medicine Hospital, Fuzhou (350001), China
  11.Department of Oncology Center, the Second School of Clinical Medicine of Binzhou Medical University, Yantai, Shandong Province (264100), China
- Author bio：
  
  Dr. KANG Ze-feng, E-mail: zefeng2531@163.com
- Funds：
  
  the National Key R&D Program of China(2022YFC3502500);the National Administration of Traditional Chinese Medicine Ophthalmology Evidence-Based Capacity Enhancement Project
- DOI：10.1007/s11655-025-3820-2
  中图分类号：
- 录用：2025-07-02，
  
  网络首发：2026-01-15，
  
  纸质出版：2026-03
- Accepted：
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HOU Xin-yue, LI Bao-hua, WANG Jian-quan, 等. Effectiveness and Safety of Auricular Acupressure Combined with Periocular Thumbtack Needle Therapy for Premyopic Children: A Multicenter, Randomized, Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2026,32(3):258-266.

HOU Xin-yue, LI Bao-hua, WANG Jian-quan, et al. Effectiveness and Safety of Auricular Acupressure Combined with Periocular Thumbtack Needle Therapy for Premyopic Children: A Multicenter, Randomized, Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2026, 32(3): 258-266.
HOU Xin-yue, LI Bao-hua, WANG Jian-quan, 等. Effectiveness and Safety of Auricular Acupressure Combined with Periocular Thumbtack Needle Therapy for Premyopic Children: A Multicenter, Randomized, Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2026,32(3):258-266. DOI： 10.1007/s11655-025-3820-2.

HOU Xin-yue, LI Bao-hua, WANG Jian-quan, et al. Effectiveness and Safety of Auricular Acupressure Combined with Periocular Thumbtack Needle Therapy for Premyopic Children: A Multicenter, Randomized, Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2026, 32(3): 258-266. DOI： 10.1007/s11655-025-3820-2.

摘要

Abstract

Objective:

To evaluate the effects and safety of auricular acupressure combined with periocular thumbtack needle (AATN) therapy for premyopia children.

Methods:

This multi-center

randomized

controlled trial was conducted in 8 Chinese hospitals

and 298 premyopic children aged 6 to 10 years were recruited between October 2020 and February 2022. Eligible participants were randomly assigned to the treatment group or the control group via a simple randomization method. All the participants in both groups were provided with standard intensive eye health instruction through phone calls

WeChat or hospital visits once a week

and the children in the treatment group received AATN therapy additionally. Following 12-week treatment

participants were followed up at 3-month intervals

with the entire study extending over a 9-month duration from baseline to the final assessment. The primary outcome was the mean change in spherical equivalent (SE) from baseline to 36 weeks. The secondary outcomes included the rate of children with stable myopia (MSR)

uncorrected visual acuity (UCVA)

axial length (AL)

corneal curvature (CC)

accommodative amplitude (AMP) and intraocular pressure (IOP) at baseline

24 and 36 weeks. Safety assessment included analysis of treatment-related adverse events (AEs)

such as allergic reactions and skin damage.

Results:

Totally

298 children with premyopia were included

151 in the treatment group and 147 in the control group. At the 36th week

the SE was –0.81±0.55 D in the control group and –0.65±0.44 D in the treatment group (

=0.002). The treatment group demonstrated superior SE control efficacy compared with the control group

with differences of –0.29±0.37 D and –0.49±0.44 D

respectively (

0.01). The children in the treatment group achieved a MSR of 57.78% with more favorable outcome than 37.10% in the control group (

0.01). The adjusted mean change in AMP from baseline to 9th month was 8.85±4.02 in the control group and 9.85±3.41 in the treatment group (

=0.018). AL increased by a mean of 0.35±0.28 mm in the control group and 0.20±0.42 mm in the treatment group (

=0.004). No significant differences in UCVA or CC were found between the two groups (

0.05) and no AEs were reported.

Conclusion:

AATN therapy was effective for controlling the onset of myopia and SE

enhancing ocular accommodation

and mitigating AL. (Registration No. ChiCTR2000039299)

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