Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial

WANG Ya-xing; LYU Jian; LU Zhen-kai; LIU Mi; FENG Wen-ye; XIE Yan-ming; LIU Guang-yu

doi:10.1007/s11655-025-4023-6

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Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial

Clinical Experience | Updated：2026-02-14

- Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial
- Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial
- Chinese Journal of Integrative Medicine 2026年32卷第1期页码：73-79
- Affiliations：
  
  1.Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100700), China
  2.Institute of Clinical Basic Medicine of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing (100700), China
  3.Operations Management Department, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing (100700), China
- Author bio：
  
  Prof. LIU Guang-yu, E-mail: liuguangyu78@126.com
- Funds：
  
  the Beijing Traditional Chinese Medicine Science and Technology Development Fund Project(BJZYYB-2023-53);the Capital Health Development Research Special Fund(2024-2-4173)
- DOI：10.1007/s11655-025-4023-6
  中图分类号：
- 录用：2025-07-11，
  
  网络首发：2025-10-20，
  
  纸质出版：2026-01
- Accepted：
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WANG Ya-xing, LYU Jian, LU Zhen-kai, 等. Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2026,32(1):73-79.

WANG Ya-xing, LYU Jian, LU Zhen-kai, et al. Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2026, 32(1): 73-79.
WANG Ya-xing, LYU Jian, LU Zhen-kai, 等. Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2026,32(1):73-79. DOI： 10.1007/s11655-025-4023-6.

WANG Ya-xing, LYU Jian, LU Zhen-kai, et al. Efficacy of Xueshuantong Injection in Reducing Residual Inflammatory Risk in Unstable Angina Patients: A Randomized Double-Blind Controlled Trial[J]. Chinese Journal of Integrative Medicine, 2026, 32(1): 73-79. DOI： 10.1007/s11655-025-4023-6.

摘要

Abstract

Objective:

To evaluate the clinical efficacy and safety of Xueshuantong Injection (Lyophilized)(XST) in reducing residual inflammatory risk (RIR) in patients with unstable angina (UA).

Methods:

This was a randomized

double-blind

parallel-controlled multicenter trial. Patients with UA were recruited from Xiyuan Hospital and Guang'anmen Hospital of the China Academy of Chinese Medical Sciences between January 2024 and March 2025. Eligible participants were randomly assigned to the treatment group (XST 500 mg

30 cases) or the control group (XST 25 mg

30 cases) in a 1:1 ratio. Both groups received intravenous XST for 10 consecutive days along with standard medical therapy. The primary outcome was change in C-reactive protein(CRP) level from baseline to post-treatment. Secondary outcomes included changes in interleukin-6 (IL-6)

matrix metalloproteinase-9 (MMP-9)

high-mobility group box 1 (HMGB1)

vascular endothelial growth factor(VEGF)

and von Willebrand factor (vWF)

as well as the Canadian Cardiovascular Society (CCS) classification

and Chinese Medicine (CM) syndrome scores. Safety was evaluated by monitoring adverse event (AE) and performing laboratory tests of liver and kidney function before and after treatment.

Results:

A total of 59 patients completed the trial (30 in the treatment group and 29 in the control group). After treatment

the treatment group showed significantly greater reductions in CRP levels compared to the control group (

0.01). In addition

the treatment group exhibited significantly improved IL-6

MMP-9

and HMGB1 levels

as well as CM symptom scores and CCS classification compared to the control group (all

0.05). No serious adverse events were reported. Compared with the control group

the treatment group receiving XST showed greater improvements in RIR and clinical symptoms in UA patients with good safety and tolerability.

Conclusion:

XST shows potential to reduce RIR in patients with UA and may inform anti-inflammatory management. (Registration No. ITMCTR2025000552)

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