Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort Study

XIN Xi-yan; WANG Yang; ZHANG Hua; ZHANG Jia-cheng; FAN Meng-jie; ZHANG Xi; XU Jing; YE Yang; HAO Xin-yu; LI Dong; LI Rong

doi:10.1007/s11655-025-4213-2

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Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort Study

Original Article | Updated：2025-12-19

- Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort Study
- Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort Study
- Chinese Journal of Integrative Medicine 2025年31卷第12期页码：1059-1068
- Affiliations：
  
  1.Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing (100191), China
  2.State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing (100191), China
  3.Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing (100191), China
  4.Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing (100191), China
- Author bio：
  
  Prof. LI Dong, E-mail: lidong6512@sina.com;
  Prof. LI Rong, E-mail: roseli001@sina.com
- Funds：
  
  the National Natural Science Foundation of China(82074193);Youth Fund of the National Natural Science Foundation of China(82301962);the Special Grant for Capital Health Research and Development(2022-2-4097);Key Clinical Projects of Peking University Third Hospital(BYSYZD2024008);Capital Medical Research & Development Fund(2024-2-4099)
- DOI：10.1007/s11655-025-4213-2
  中图分类号：
- 录用：2025-01-08，
  
  网络出版：2025-10-27，
  
  纸质出版：2025-12
- Accepted：
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XIN Xi-yan, WANG Yang, ZHANG Hua, 等. Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort Study[J]. Chinese Journal of Integrative Medicine, 2025,31(12):1059-1068.

XIN Xi-yan, WANG Yang, ZHANG Hua, et al. Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort Study[J]. Chinese Journal of Integrative Medicine, 2025, 31(12): 1059-1068.
XIN Xi-yan, WANG Yang, ZHANG Hua, 等. Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort Study[J]. Chinese Journal of Integrative Medicine, 2025,31(12):1059-1068. DOI： 10.1007/s11655-025-4213-2.

XIN Xi-yan, WANG Yang, ZHANG Hua, et al. Wenyang Lishui Formula Ameliorates Symptoms of Ovarian Hyperstimulation Syndrome: A Prospective Cohort Study[J]. Chinese Journal of Integrative Medicine, 2025, 31(12): 1059-1068. DOI： 10.1007/s11655-025-4213-2.

摘要

Abstract

Objective:

To study the clinical efficacy of Wenyang Lishui Formula (WYLSF) in preventing ovarian hyperstimulation syndrome (OHSS) and explore the suitable range of estradiol (E

) on the human chorionic gonadotropin (HCG) day in patients with OHSS using WYLSF.

Methods:

Part Ⅰ: eligible patients at high risk for OHSS undergoing ovulation induction between January and December

2023 were randomized into 2 groups based on the actual treatment. The treatment group received 200 mL WYLSF formula twice daily for 5 days after oocyte retrieval in a combination of lifestyle coaching (LC) intervention including regular diet and exercise

whereas the LC group received LC intervention alone. The incidence of OHSS

OHSS self-assessment scales

changes in E

levels on HCG day and 5 days after oocyte retrieval

ovarian morphology changes

and menstrual recovery were compared between the two groups. Part Ⅱ: patients at high risk for OHSS treated with WYLSF were studied. The optimal E

threshold on the HCG day was determined using the maximum selection test

and a multivariate analysis was adopted to compare the relationship between different E

levels on HCG day and hospitalization rate

incidence of moderate to severe OHSS

and self-assessment scales

to explore the preventive effect of WYLSF on OHSS in patients with varying E

levels.

Results:

total of 120 patients were included in the Part Ⅰ analysis. The treatment group (60 cases) showed a significant reduction in the incidence

duration

and severity of abdominal distension

as well as the incidence of vomiting compared with the LC group (

0.05). The post-retrieval E

levels in the treatment group decreased significantly more (

=0.032). Among 1

652 patients treated with WYLSF in the Part Ⅱ

90 patients with ≤10092 pmol/L

159 with

31074 pmol/L

and 1

403 in the middle range group were formed based on E

levels on HCG day in Part two analysis. Univariate and regression analyses showed that patients with E

levels

31073 pmol/L had a significantly higher incidence of moderate to severe OHSS compared to those with E

levels ≤10092 pmol/L (

0.05).

Conclusions:

WYLSF can effectively reduce specific symptoms in high-risk OHSS patients after ovulation induction and significantly lower E

levels. It may be more suitable for high-risk OHSS patients with E

levels

31073 pmol/L on HCG day. (Registration No. MR-11-23-032493

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