Latest Issue
2009 Year 15 Vol. 4 Issue
- Keywords：Migraine;Naproxen Sodium;Zolmitriptan;Ergotamine;Rizatriptan
- 799
- |
- 353
- |
- 1
Published：2021-08-27 - Keywords：Migraine;Migraine Attack;Acupuncture Treatment;Rizatriptan;Pizotifen
- 925
- |
- 312
- |
- 3
Published：2021-08-27 -
Treatment of migraine from the view of disease diagnosis and syndrome differentiation in combination
Keywords：Migraine;Chinese Medicine;Sumatriptan;Ergotamine;Flunarizine- 775
- |
- 362
- |
- 5
Published：2021-08-27 - Abstract：To assess the effect and adverse reaction of Qufeng Zhidong Recipe (祛风止动方, QZR) in treating children’s tic disorder (TD). With multicenter randomized parallel open-controlled method adopted, the patients enrolled were assigned to two groups, 41 cases in the Chinese medicine (CM) group and 40 in the Western medicine (WM) group. They were treated by QZR and haloperidol plus trihexyphenidyl respectively for 12 weeks as one course. In total, two courses of treatment were given. The curative effect and adverse reactions were evaluated by scoring with Yale Global Tic Severity Scale (YGTSS), Traditional Chinese Medicine Syndrome Scale (TCMSS), and Treatment Emergent Symptom Scale (TESS), as well as results of laboratory examinations. After one course of treatment, the markedly effective rate in the CM and the WM group was 14.6% and 17.5%, respectively, and the total effective rate 43.9% and 47.5%, respectively, which showed insignificant difference between groups (P>0.05). However, after two courses of treatment, markedly effective rate in them was 73.2% and 7.5%, and the total effective rate was 100.0% and 57.5%, both showing significant differences between groups (P<0.05). Besides, the adverse reactions occurred in the CM group was less than that in the WM group obviously. QZR has definite curative effect with no apparent adverse reaction in treating TD, and it can obviously improve the symptoms and signs and upgrade the quality of life and learning capacities in such patients.Keywords：tic disorder;Chinese Medicine;Qufeng Zhidong Recipe;haloperidol;multicenter study
- 1007
- |
- 351
- |
- 7
Published：2021-08-27 - Abstract：To explore the clinical efficacy of integrative Chinese and Western medicine in treating Tourette syndrome (TS). Ninety children with TS were randomized into two groups by randomizing: digital table method: the 60 patients in the treated group were treated by Ningdong Granule (宁动颗粒, NDG) plus haloperidol, and the 30 in the control group treated by haloperidol alone. The course for both groups was 6 months. Conditions of the patients were estimated before and after treatment with Yale Global Tic Severity Scale (YGTSS), the short-term efficacy, adverse reaction of treatment were assessed at the end of treatment, and the long-term efficacy as well as the recurrent rate were evaluated half a year after the treatment was ended. Of the 60 patients in the treated group, the treatment on 36 was evaluated as remarkably effective, 21 as effective, and 3 as ineffective, the total effective rate being 95.0% (57/60), while of the 30 patients in the control group, the corresponding data were 9, 13, 8 and 73.3% (22/30), respectively, differences between groups in markedly effective rate and total effective rate were statistically significant (χ2=7.20, and χ2=6.85, P<0.01). The improvement on the condition of illness, motor tic and vocal tic, as well as the long-term efficacy of treatment were all better in the treated group than in the control group (P<0.05 or P<0.01). The incidence of adverse reaction and the recurrent rate in the treated group were 13.3% (8/60) and 8.3% (5/60) respectively, all were lower than those in the control group, 36.7% (11/30) and 43.3 (13/30), showing statistical significances (P<0.05 and P<0.01). Integrative medical treatment on TS was markedly effective in clinical practice with less adverse reaction and lower recurrent rate.Keywords：Tourette syndrome;integrative Chinese and western medical treatment;Clinical Observation
- 815
- |
- 344
- |
- 14
Published：2021-08-27 - Abstract：To investigate the impacts of Xuezhikang (血脂康, XZK) or pravastatin combined with antihypertensive drugs on circulating endothelial progenitor cells (CEPCs) in essential hypertensive (EH) patients. Eighty-eight EH patients were enrolled into the study and randomly assigned to the antihypertensive drug treatment group (ATH group, 29 cases), the pravastatin treatment group (PRA group, 29 cases) and the Xuezhikang treatment group (XZK group, 30 cases). Patients in the 3 groups were treated with routine antihypertensive drugs. In addition, pravastatin and Xuezhikang were given to the patients in the PRA group and XZK group, respectively. After an eight-week treatment, CEPCs were counted using a laser scanning confocal microscope, and their proliferation function was evaluated by the MTT colorimetric assay and the adherent cell number was counted to estimate the adhesion function. After the treatment, CEPCs in the PRA group (116.60±5.70) and XZK group (114.40±6.55) was significantly higher than that in the ATH group (88.00±6.32, P<0.01). CEPCs proliferation capability and the adhesion function in the PRA group (0.406±0.016, 33.60±4.26) and XZK group (0.415±0.018, 34.30±3.77) were obviously superior to those in the ATH group (0.333±0.021, P<0.01; 23.30±3.19, P<0.01). No significant difference was found between the pravastatin group and the XZK group. Combined use of XZK or pravastatin with the anti-hypertensive therapy could increase the CEPCs number and improve their function in EH patients with the blood pressure controlled by antihypertensive drugs, leading to benefits independent of pressure-lowering effects.Keywords：Essential Hypertension;endothelial progenitor cell;pravastatin;Xuezhikang
- 934
- |
- 341
- |
- 13
Published：2021-08-27 - Abstract：To investigate the efficiency, safety, and possible mechanisms of Qingre Buyi Decoction (清热补益煎剂, QBD) in the treatment of acute radiation proctitis (ARP). This study was a single center, prospective, single blind, randomized, and placebo-controlled clinical trial. A total of 60 patients with ARP was equally and randomly distributed into the control group (conventional treatment) and the combination group (conventional treatment plus QBD). The changes of main Chinese medicine clinical symptoms and signs, including stomachache, diarrhea, mucous or bloody stool before and after treatment, and their adverse reactions were observed after the two-week treatment. Also, D-lactate and diamine oxidase (DAO) levels, hepatic and renal function were measured. Cure rates, effective rates, and recurrence rates were compared between the two groups. The blood levels of both DAO and D-lactate were significantly decreased in the combination group as compared with those in the control group (P<0.05 or P<0.01). All main clinical symptoms and signs were alleviated more significantly in the combination group (P<0.01). The main symptom scores also were significantly decreased after treatment in the control group (P<0.01), except those for mucous or bloody stool (P>0.05). Compared to the control group, the improvements of stomachache, diarrhea, defecation dysfunction, and stool blood in the combination group were significantly better (P<0.05 or P<0.01). For the combination group, the curative rate, effective rate, and recurrence rate was 76.67%, 16.67%, and 6.67%, respectively. On the other hand, for the control group, the rate was 53.33%, 16.67%, and 30.00%, respectively. The total curative effect was significantly better in the combination group than in the control group (P<0.05). However, the recurrence rate was similar between the two groups (P>0.05). The hepatic and renal function remained normal in both groups (P>0.05). In addition, no severe adverse event was found in both groups. Addition of QBD to the conventional treatment can effectively alleviate the damage of intestinal mucosal barrier function and improve all main clinical symptoms and signs of the ARP. The combination of conventional treatment with Chinese herbal medicine QBD is effective and safe for ARP.Keywords：Qingre Buyi Decoction;acute radiation proctitis;Chinese Herbal Medicine
- 870
- |
- 341
- |
- 9
Published：2021-08-27 - Abstract：To observe the effects of the external application of Qiyu oil (芪榆油) gauze (QYOG) for promoting post-operational healing in patients with anal fistula and to explore its mechanism of action so as to provide a beneficial scientific basis for its wide use. Sixty patients with anal fistula scheduled to receive simple low anal fistulectomy were equally assigned, according to the sequence of hospitalization, to the tested group and the control group, and their wounds were classified according to longitudinal diameter into three grades (Grade I with a diameter below 2 cm; Grade II, 2–5 cm; and Grade III, over 5 cm). After the operation was completed and the operational wound was sterilized with benzalkonium bromide, the wound substratum was packed with QYOG in the test group and with vaseline gauze in the control group. The packing gauze was changed every day till the wound was healed. The healing time of the patients was observed, and the number of capillaries and positive cell percentages of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and epidermal growth factor (EGF) in wound granulation tissues were counted on the 5th day after the operation. The wound healing time was 17.80±5.46 days in the test group, which was significantly shorter than that in the control group (21.90±6.32 days, P<0.01). The number of capillaries and positive cell percentages of VEGF and bFGF in wound granulation tissues on the 5th day in the tested group were higher than those in the control group (P<0.01), though the difference in EGF between the two groups was insignificant (P>0.05). QYOG could shorten the wound healing time after anal fistulectomy, which suggests that it participates in the stimulation of wound granulation tissues to produce VEGF and bFGF, and thus promotes capillary genesis and improves blood circulation in wounds so as to promote wound healing.Keywords：Qiyu oil gauze;anal fistula;wound healing;vascular endothelial growth factor;basic fibroblast growth factor;epidermal growth factor;number of blood capillary
- 869
- |
- 355
- |
- 4
Published：2021-08-27 - Abstract：To investigate the inhibitory effects of Kangjia Pill (抗甲丸, KJP) on the cell proliferation in rat goiter model induced by methimazole (MMI). Fifty-six Wistar rats were randomly divided into four groups: the normal group, MMI model group (MMI), low dose of KJP group (LKJP), and high dose of KJP (HKJP). Except the normal group (20 rats), the other groups (12 rats in each) were given 0.04% (w/v) MMI through the drinking water until the end of the experiment. One week later, the rats in the LKJP and HKJP groups were given KJP by gastrogavage at the dose of 250 mg/(kg · d) and 1 000 mg/(kg · d), respectively for 12 weeks. The relative thyroid weight (mg/100 g body weight) of each rat was accessed. The expression of proliferating cell nuclear antigen (PCNA) was determined by immunohistochemistry, and the correlation analysis between the PCNA positive thyrocytes and the relative thyroid weight was performed. The expressions of PCNA and cyclin D1 were examined with Western blotting. After KJP treatment for 12 weeks, compared with the MMI group, the relative thyroid weight of the HKJP group decreased significantly, and the positive thyrocyte populations of PCNA in the two KJP groups reduced markedly (all P<0.05). The correlation analysis showed that PCNA was closely correlated with thyrocyte proliferation (r=0.685, P<0.05). KJP significantly decreased the protein expression of PCNA and cyclin D1 in the thyroid specimens (P<0.05), the high dose showed better effects. KJP played a therapeutic role via inhibiting cell proliferation in the rat goitrous glands.Keywords：goiter;Chinese Medicine;cell proliferation;proliferating cell nuclear antigen;cyclin D1
- 751
- |
- 420
- |
- 0
Published：2021-08-27 - Abstract：To investigate the effects of Kangquan Recipe (康泉方, KQR) on sex steroids and cell proliferation in an experimental benign prostatic hyperplasia (BPH) model in rats. Seventy-two SD rats were randomly divided into six groups: the normal group, the model group, the finasteride group, and the low-, middle-, and high-dose KQR groups, 12 in each group. Except those in the normal group, the rats were injected with testosterone after castration for the establishment of BPH model and then given respectively with normal saline, finasteride, and low-, middle-, and high-dose of KQR for 30 days. The levels of plasma testosterone (T) and estradiol (E2) were determined by enzyme-linked immunosorbent assay (ELISA), and the mRNA expression ) of proliferating cell nuclear antigen (PCNA) in prostate tissue was detected by reverse transcription-polymerase chain reaction (RT-PCR) after administration. Compared with the model group, the prostate weight, the plasma T, and the mRNA expression of PCNA were significantly lower, and the plasma E2 and the ratio of E2/T were higher in the three KQR groups (P<0.05 or P<0.01). There was no significant difference in the prostate weight, plasma T and E2, and ratio of E2/T among the finasteride group and the three KQR groups (P>0.05). The mRNA expressions of PCNA were significantly higher in the middle- and low-dose of KQR groups than those in the finasteride group (P<0.05). KQR shows multitarget effects on experimental BPH rats, and the mechanism might be related with regulating the balance of plasma T and E2 and decreasing the PCNAmRNA expression in prostate tissue to restrain cell proliferation in a dose-dependent manner.Keywords：Kangquan Recipe;benign prostatic hyperplasia;Testosterone;estradiol;cell proliferation
- 847
- |
- 363
- |
- 7
Published：2021-08-27 - Abstract：To explore the effects of Zuojin Pills (左金丸) and its similar formulas on the stomach cold syndrome in a Wei cold model in rats. The rat Wei cold model was established by intragastric administration of glacial NaOH, and the gastric mucosa injury indices, together with the levels of motilin and gastrin in the stomach, were determined. The preventive and curative effects of Zuojin Pills and its similar formulas on gastric mucosa injury were investigated. Zuojin Pills and its similar formulas could protect the gastric mucosa in the gastric cold model in rats at different levels. Fanzuojin Pills (反左金丸) had the best effect in inhibiting gastric mucosa injury. The different pharmacological effects of Zuojin Pills and its similar formulas in the rat gastric cold model were partially correlated with the degrees in cold and heat properties of the formulas.Keywords：Zuojin Pills;similar formula;rat;Wei cold syndrome
- 785
- |
- 356
- |
- 5
Published：2021-08-27 - Abstract：To observe the clinical efficacy of Yinzhihuang Oral Liquid (YOL, 茵栀黄口服液) to prevent the premature infantile jaundice. After excluded hemolytic, suffocation, infection, and the very low birth weight, 242 cases of premature infants were randomly assigned to two groups, the treatment group and the control group. Both groups were taken conventional procedures, such as warmth, feeding, and blood glucose monitoring, and the treated group was administered YOL 5 mL each time, twice daily additionally, and the control group without any treatment. The percutaneous bilirubin and blood cells were observed every day. Compared the two groups, the jaundice indices were more significantly different at 24–48 h, 48–72 h, and more than 72 h (P<0.05), but not statistically different at 0–24 h (P>0.05). Hemoglobin, reticulocyte, platelets, and leucocyte were not significantly different between the two groups (P>0.05). YOL as an early intervention has positive significance to decrease the incidence of pathological jaundice in the premature infants, and no significant impact on the blood cells.Keywords：premature infants;jaundice;early intervention;Yinzhihuang Oral Liquid;blood cells
- 832
- |
- 320
- |
- 6
Published：2021-08-27 - Abstract：To observe the effect of Yangyin Humo Decoction (养阴护膜饮, YHD) on oral mucomembranous reaction in patients with head-neck tumor undergoing radiotherapy. Forty-Forty-two patients with head-neck tumor undergoing radiotherapy were randomized equally into two groups. The two conventional Western medical treatment was administered to all, including intravenous dripping of 2% lidocaine 20 mL, dexamethasone 5 mg, gentamycin 80 000 units, vitamin B12 5 mg, dissolved in saline 250 mL, and 5% sodium bicarbonate solution for gargling, but to the patients in the tested group, YHD was given additionally. The medication was started simultaneously all through the whole course of the radiotherapy. Patients were examined every day to observe and compare the degree, initiating time, and repairing time of their oral lesions; the dosage of radiation they received was recorded as well. The degree of mucomembranous reaction that appeared in most patients in the test group was of grade 1–2, while in the control group, it was grade 2–3. The average time for oral lesion of 1, 2, 3 grades to be initiated in the test group was 12.0±1.1, 11.0±1.3 and 10.0±0.8 days, respectively, after radiation started, which was later than that in the control group (P<0.01). Moreover, the average repairing time for the lesions of grades 1, 2, and 3 in the test group was 3.0±0.7, 10.0±1.3 and 19.0±0.8 days, which were shorter than those in the control group respectively (P<0.01). The radiation applied on the primary tumor of patients with oral lesion of grade 1–3 in the test group was 24.2±2.2, 42.0±2.6 and 58.0±1.6 Gy on the average, respectively, which were higher than that applied on patients in the control group (P<0.05 or P<0.01). The Chinese herbal preparation YHD could alleviate oral mucomembranous reaction to radiation applied in patients with head-neck tumor.Keywords：radiotherapy;Chinese herbal treatment;radio-protector
- 844
- |
- 332
- |
- 5
Published：2021-08-27 - Abstract：The inflammation factors and roles of them in acute coronary syndrome (ACS) were explored. The similarity between the theory of pathogenic toxin in Chinese Medicine and the inflammation response theory in ACS was discussed. The exploration of new inflammatory factors may be helpful for Chinese Medicine in the research of ACS.Keywords：pathogenic toxin;inflammation factors;acute coronary syndrome
- 857
- |
- 359
- |
- 1
Published：2021-08-27 - Abstract：Pain is the most common symptom in clinics. Therefore, the quality, time course and location of pain are important for the diagnosis and treatment. However, pain is very difficult to define, and it is one of the conditions poorly understood by the medical sciences. In Western medicine pain is often described in terms of a penetrating or tissue-destructive process and/or emotional reactions, but in Chinese medicine the pathogenesis and description of pain are different. It is described based on the theories and pathogenesis of Chinese medicine, and the patients’ feeling according to their languages and cultures. Thus, when taking the history and conducting physical examination in patients in China and treating them according to Chinese medicine, we have to know how these patients express and describe their pain when they go to clinics. This article will explain some terms and words in the Chinese language and their corresponding terms in the English language.Keywords：Chinese Medicine;Chinese medicine patterns;pain
- 833
- |
- 335
- |
- 0
Published：2021-08-27
OriginalPaper
- Abstract：The anti-tumor effects of Chinese herbal medicines and their prescription preparations attracted more and more attention at home and abroad. Thus, it is becoming a hot research topic to exploit the anti-tumor mechanisms of Chinese medicine, and some of them have been partly clarified with the improved research ability to date. In brief, the Chinese herbal medicines possess unique advantages on the treatment of tumors through their multiple actions on multiple targets.Keywords：tumor;Chinese Medicine;mechanism of action;multitarget
- 1045
- |
- 338
- |
- 16
Published：2021-08-27
ReviewPaper
- 邮编：100091
- 联系电话：010-62886827, 62877592 传真：010-62874291
- 技术支持由北京北大方正电子有限公司提供 京ICP备05067934号-1
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
0