Latest Issue
2011 Year 17 Vol. 9 Issue
- Keywords：knee osteoarthritis;Aspirin Resistance;Electric Acupuncture;Integrative Medical Treatment;Clin Rehabilit Tissue Engin
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Published：2021-08-27 - Keywords：Chinese Medicine;Western Medicine;Continue Professional Development;Chinese Philosopher;Philosophical Concept
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Published：2021-08-27 - Abstract：To explore the most effective herbal combinations commonly used by highly experienced Chinese medicine (CM) physicians for the treatment of insomnia. We collected and analyzed data related to insomnia treatment from the clinics of 7 highly experienced CM physicians in Beijing. The sample included 162 patients and 460 consultations in total. Patient outcomes, such as sleep quality and sleep time per day, were manually collected from the medical records by trained CM clinicians. Three data mining methods, support vector machine (SVM), logistic regression and decision tree, and multifactor dimensionality reduction (MDR), were used to determine and confirm the herbal combinations that resulted in positive outcomes in patients suffering from insomnia. Results show that MDR is the most efficient method to predict the effective herbal combinations. Using the MDR model, we identified several combinations of herbs with 100% positive outcomes, such as stir-fried spine date seed, Szechwan lovage rhizome, and prepared thinleaf milkwort root; white peony root, golden thread, and stir-fried spine date seed; and Asiatic cornelian cherry fruit with fresh rehmannia. Results indicate that herbal combinations are effective treatments for patients with insomnia compared with individual herbs. It is also shown that MDR is a potent data mining method to identify the herbal combination with high rates of positive outcome.Keywords：Chinese Medicine;insomnia treatment;highly experienced Chinese medicine physician;herb combinations;multifactor dimensionality reduction;data mining
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Published：2021-08-27 - Abstract：To find an appropriate feature representation in the biclustering of symptom-herb relationship in Chinese medicine (CM). Four different representation schemes were tested in identifying the complex relationship between symptoms and herbs using a biclustering algorithm on an insomnia data set. These representation schemes were effective count, binary value, relative success ratio, or modified relative success ratio. The comparison of the schemes was made on the number and size of biclusters with respect to different threshold values. The modified relative success ratio scheme was the most appropriate feature representation among the four tested. Some of the biclusters selected from this representation scheme were known to follow the therapeutic principles of CM, while others may offer clues for further clinical investigations.Keywords：feature representation;biclustering;Chinese Medicine;symptom-herb relationship
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Published：2021-08-27 - Abstract：To evaluate the safety and efficacy of Xiongshao Capsule (芎芍胶囊, XS), consisting of Chuangxiongol and paeoniflorin, in preventing restenosis after percutaneous coronary intervention (PCI) in senile coronary heart disease (CHD) patients. A multi-center, randomized, double-blind, placebo-controlled trial was conducted. A total of 335 CHD patients were randomly assigned to treatment with oral administration of XS, or a placebo for 6 months after successful PCI. A clinical follow-up was performed at 1, 3 and 6 months after PCI and an angiographic follow-up was scheduled at 6 months. The primary endpoint was angiographic restenosis defined as a luminal stenosis ⩾ 50% in follow-up. The secondary endpoints were combined incidence of death, target lesion nonfatal myocardial infarction, repeat target-vessel angioplasty, and coronary artery bypass graft surgery (CABG). The follow-up for the above clinical endpoint events was continued to 1 year after PCI. The subgroup analysis of 152 senile patients (68 cases angiographic follow-up) showed that the restenosis rates tended to reduce in the XS group as compared with that in the placebo group (24.32% vs. 38.71%, P > 0.05), and the minimum lumen diameter (MLD) significantly increased in the follow-up (2.15 ± 0.84 for XS vs. 1.73 ± 0.91 for placebo, P < 0.05). The incidence of recurrent angina at 3 and 6 months after PCI was also significantly reduced in the XS group (4.11% and 12.33%) as compared with those in the placebo group (17.72% and 43.04%), but there was no significant difference in the combined incidence of clinical outcomes (6.85% in the XS group vs. 11.39% in the placebo group, P > 0.05). No significant adverse reactions occurred within the 6-month follow-up period in the XS group. Administration of XS in addition to standardized Western medication for 6 months is demonstrated to be safe and effective in reducing post-PCI recurrent angina and inhibiting luminal restenosis after PCI in senile CHD patients.Keywords：coronary heart disease;senile;Percutaneous Coronary Intervention;restenosis;Xiongshao capsule;active blood circulation
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Published：2021-08-27 - Abstract：To define if such crucial body composition parameters like body density (Db) and body surface area (BSA) could be considered in the frame of yin-yang concept, i.e., one of the most popular in conventional biomedical science theories of Chinese medicine. Standardized Eurofit Pysical Fitness Test Battery reports of 715 junior school children have been evaluated for association of their body composition parameters with corresponding motoric fitness test results. Equations for BSA and Db calculation included height, weight, and skin-fold thickness values of the tests. Correlative analysis of major physical fitness parameters, obtained from 715 junior school children, demonstrated that participants with high BSA/Db ratio had better yang-featured anaerobic performance, whereas those with low BSA/Db ratio presented with better yin-featured aerobic performance. This result coincided with proposed suggestions to treat BSA as external yang component and Db as internal yin component of body composition. Calculated confidence intervals for BSA/Db ratio ranged between 1.073–1.15, which can be accepted as optimal for junior school children yang/yin ratio of body composition. Easily accessible BSA and Db can provide specialists with useful preliminary information for generating reasonable exercise and nutritional programs.Keywords：body composition;yin;yang;body density;Body Surface Area
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Published：2021-08-27 - Abstract：To explore the association of Chinese medicine constitution susceptibility to diabetic nephropathy (DN) and transforming growth factor (TGF)-β1 (T869C) gene polymorphism. TGF-β1 gene polymorphism detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was screened for 180 DN cases and 180 type 2 diabetic mellitus (T2DM) cases without combined DN. Patients with DN were surveyed epidemiologically with constitution in the Chinese medicine questionnaire (CCMQ). Binary logistic regression analysis was utilized to study the correlation between nine types of Chinese medicine constitution and TGF-β1 (T869C) gene polymorphisms. The DN group has a higher frequency of TGF-β1 (T869C) gene polymorphism than the T2DM group, and CC/CT genotypes than the T2DM group [CC, CT, TT (DN group): 88, 87, 5 (cases) versus (T2DM group) 71, 73, 36 (cases), P<0.05]. The phlegm-dampness constitution, damp-heat constitution, and blood stasis constitution have correlations with TGF-β1 (T869C) gene polymorphism. Chinese medicine constitutions were associated with TGF-β1 (T869C) gene polymorphism, a potential predictor of susceptibility to DN in T2DM patients.Keywords：diabetic nephropathy;gene polymorphism;transforming growth factor-β1;Chinese medicine constitution
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Published：2021-08-27 - Abstract：To investigate the cellular effects of Pien Tze Huang (片仔癀, PZH) in the HT-29 human colon carcinoma cell line. The viability of HT-29 cells was determined by MTT assay. A fluorescence-activated cell sorting (FACS) analysis with annexin-V/propidium iodide (PI) and JC-1 staining were performed to determine cell apoptosis and the loss of mitochondrial membrane potential, respectively. Activation of caspase 3 was evaluated by a colorimetric assay. The mRNA expression levels of Bcl-2 and Bax were measured by reverse transcription polymerase chain reaction (RT-PCR). PZH, in a dose- and timedependent manner, reduced viability and induced apoptosis of HT-29 cells. Moreover, PZH treatment resulted in the collapse of the mitochondrial membrane potential, activation of caspase 3, and an increase in the Bax/Bcl-2 ratio. PZH inhibits the growth of HT-29 cells by inducing cancer cell apoptosis via regulation of the Bcl-2 family and activation of caspase 3, which may, in part, explain its anticancer activity.Keywords：Pien Tze Huang;Chinese Medicine;colon cancer;apoptosis;HT-29 cells
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Published：2021-08-27 - Abstract：To study the inhibitory effect of Fuzheng Yiliu Granule (扶正抑瘤颗粒, FYG) on hepatocellular cancer (HCC) and investigate the mechanism mediating its bioactivity. H22 tumor-bearing ICR mice were treated with FYG [3.6 g/(kg·d)] for 5 days. Tumor volume and tumor weight, percentages of CD3+, CD4+, CD8+, and natural killer (NK) cells in peripheral blood, tumor apoptosis and serum levels of interleukin-2 (IL-2), and tumor necrosis factor-α (TNF-α) were evaluated. FYG-containing serum was prepared from SD rats treated for 7 days [high dose 3.6 g/(kg·d); middle dose 1.8 g/(kg·d); low dose 0.9 g/(kg·d)]. Cell cycle, cell viability, and apoptosis were evaluated after HepG2 cell line was cultured in FYG-containing serum for 48 h. The levels of IL-2 and TNF-α in FYG-containing serum were also determined. FYG produced a potent antitumor effect (P<0.01) and induced marked apoptosis of the tumor tissue (P<0.05). Mice treated with FYG had higher percentages of CD3+ and CD4+ (P<0.05), and more NK cells (P<0.01) in the peripheral blood than those in the animals treated with normal saline. Mice receiving FYG had the highest serum levels of IL-2 and TNF-α (P<0.01). High-dose FYG-containing serum significantly decreased HepG2 cell viability, inhibited cell proliferation (P<0.05), and induced apoptosis (P<0.01). In addition, the levels of IL-2 and TNF-α of high-dose-containing serum were higher than the blank serum (P<0.01). FYG could inhibit HCC growth by regulating immune function and inducing apoptosis of tumor cells in vivo and in vitro.Keywords：Fuzheng Yiliu Granule;hepatocellular cancer;immune function;apoptosis
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Published：2021-08-27 - Abstract：To study the polypharmacological mechanism of herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall (HP CXR-PAP) on the treatment for osteoarthritis (OA). Chemical space was used to discuss the similarities and differences between the molecule sets of HP CXR-PAP and drugs. Docking protocol was used to study the interaction between HP CXR-PAP and OA target enzymes. The similarities and differences of HP CXR-PAP and drugs in target spaces were elucidated by network features. The plots between the molecule sets of HP CXR-PAP and drugs in chemical space had the majority in the same region, and compounds from HP CXR-PAP covered a much larger additional region of space than drug molecules, which denoted the diverse structural properties in the molecule set of HP CXR-PAP. The molecules in HP CXR-PAP had the properties of promiscuous drugs and combination drug, and both HP CXR-PAP ligand-target interaction network and drug ligand-target interaction network were similar in the interaction profiles and network features, which revealed the effects of multicomponent and multitarget. The clue of potential synergism was obtained in curing OA disease by Chinese medicine, which revealed the advantages of Chinese medicine for targeting osteoarthritis disease.Keywords：herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall;chemical space;virtual screening;target space;computational pharmacology;osteoarthritis
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Published：2021-08-27 - Abstract：To study the characteristics of lymphocyte nuclear factor kappa B (NF-κB) signal transduction kinase-related molecular mRNA differential expressions at various month age segments in aging process and the intervening effect of Epimedium flavonoids (EF) on it. Sixty SD rats were divided into six groups, according to animals’ age, i.e., the 3 days (d) group, the 4 months (m) group, the 10 m group, the 18 m group, the 27 m group, and the 27 m+EF group. RNA was extracted from separated splenic lymphocytes. Adopting NF-κB signal path functional genome oligonucleotide gene-chip (128 related genes), the integral characteristics and differences of NF-κB signal transduction kinase-related mRNA expressions were determined, and the intervening effect of EF was examined. The mean level of the NF-κB signal transduction kinase-related mRNA expressions in rats’ splenic lymphocytes lowered with aging; the highest expression was presented at 3 d after birth, and then, it lowered gradually, with the lowest level at 18 m or 27 m. After EF intervention, the expression level was raised to the 10–18 m level in the aged rats. The changing rules of lymphocyte NF-κB-signal-transduction-kinase-related mRNA expressions in various stages of aging are helpful for selecting the well time for preventing and intervening aging, and will also give a hint to the molecular index for assessment of senility retarding researches.Keywords：nuclear factor-κB signal transduction kinase;gene-chip;lymphocyte;aging;immunosenescence;Epimedium flavonoids;mRNA
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Published：2021-08-27 - Abstract：To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin (OPN) and quality of life (QOL) in patients with primary Sjogren's syndrome (pSS) and to study the correlation between OPN level and the disease. Sixty-eight pSS patients were randomly assigned to two groups: the treatment group (35 cases) treated by Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment, immunoglobulin G (IgG) level, erythrocyte sedimentation rate (ESR), and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control. Before treatment, levels of IgG, ESR, and OPN in patients were higher than those in the normal control. After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group (P<0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (P<0.05) and higher in the treatment group than in the control group after treatment (P<0.05). Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR, and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis could alleviate pSS disease and improve the QOL. In addition, the OPN level might be used as an evaluating index for pSS disease.Keywords：primary Sjogren's syndrome;Chinese Herbal Medicine;strengthening qi;nourishing Yin;removing stasis;quality of life
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Published：2021-08-27
OriginalPaper
- Abstract：Many laboratories have been attempting to integrate Chinese medicine (CM) with the research of stem cells in order to explore this promising frontier. Studies on the combination of CM and bone marrow-derived mesenchymal stem cells (BMSCs) have found that some effective components from CM could activate endogenous stem cells and induce stem cells to differentiate into neural-like cells in vitro and promote angiogenesis. This review summarized the latest research findings of BMSCs and their application combined with CM in the treatment of cerebral ischemia.Keywords：bone marrow-derived mesenchymal stem cells;Chinese Medicine;Cerebral Ischemia
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Published：2021-08-27
ReviewPaper
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