Latest Issue
      2018 Year 24 Vol. 8 Issue

        OriginalPaper

      • Zhao-you Tang
        2018, 24(8): 563-567. DOI: 10.1007/s11655-018-2990-6
          
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      • Tian Zhou,Kai-wen Hu
        2018, 24(8): 568-572. DOI: 10.1007/s11655-018-2988-0
          
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      • Tong Zhang,Wen-ting He,Ming-jie Zi,Gang Song,Dan-hui Yi,Yu-fei Yang
        2018, 24(8): 573-578. DOI: 10.1007/s11655-018-2980-0
        Abstract：To investigate the efficacy of integrated Chinese and Western medicine (IM) in the treatment of metastatic colorectal cancer (mCRC) in a cohort study. The survival outcome of patients receiving IM was compared with that of patients receiving Western medicine alone. The study design was adopted with “continuous administration of Chinese medicine for ⩾ 3 months” as the exposure factor. Patients who met this exposure factor were assigned to the IM cohort (Group A, 110 patients). Patients who did not meet this exposure factor were assigned to the Western medicine cohort (Group B, 225 patients). The overall survival (OS), progression-free survival (PFS), and 1st year, 2nd year, and 3rd year survival in the two cohorts were compared. The median OS in Group A and B were 18 months [95% confidence interval (CI) 15–21] and 16 months (95% CI 14–18), respectively, and the median PFS in Group A and B were 6 months (95% CI 4–7) and 5 months (95% CI 4–6), respectively. No statistically significant differences were observed between the groups (P=0.186, P=0.223). Group A demonstrated significantly longer OS and PFS than Group B in the following subgroups: female patients, patients with lesions in the right half of the colon, and those who received first-line treatment (P<0.05). In the subgroup of elderly patients (age>65 years), the OS in Group A was longer than that in Group B (P<0.05). IM could prolong the survival of patients with mCRC. (Registry No. ChiCTR-IOR-17010497)  
        Keywords：cohort study;metastatic colorectal cancer;Integrative Medicine   
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        Published：2021-08-27
      • Wen Sun,Jian Yu,Gu-lan Zeng,Bing-feng Zhang
        2018, 24(8): 579-583. DOI: 10.1007/s11655-017-2961-3
        Abstract：To provide an objective reference for the syndrome types of Chinese medicine (CM) associated with pediatric primary nephrotic syndrome (PNS). A cross-sectional study was performed. Data on clinical symptoms, CM syndrome types, biochemical indices, and medications used were collected from 98 children with PNS. Then, the correlation between CM syndromes and biochemical indices, as well as medications used, was analyzed. The four most common symptoms in children with PNS were brown urine, red tongue, excessive sweating, and swelling of the face and limbs. The syndromes of qi deficiency of Fei (Lung) and Shen (Kidney) (FSQD) and yin deficiency of Gan (Liver) and Shen (GSYD) were the most common main CM syndrome types. FSQD syndrome score correlated significantly with the total cholesterol level, urine protein/creatinine ratio, and urine IgG and albumin levels (P<0.01 or P<0.05). The use of maintenance glucocorticoids combined with immunosuppressive agents correlated with FSQD syndrome, and the use of maintenance glucocorticoids alone correlated with GSYD syndrome (P<0.05). Two of the most common CM syndrome types were FSQD and GSYD syndromes. FSQD syndrome may be caused by some factors related to lipid levels, protein loss, and the use of immunosuppressive agents. The use of maintenance glucocorticoids may cause GSYD syndrome  
        Keywords：primary nephrotic syndrome;Chinese Medicine;Syndrome Type;correlation analysis   
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        Published：2021-08-27
      • Karl Peltzer,Supa Pengpid
        2018, 24(8): 584-590. DOI: 10.1007/s11655-016-2748-y
        Abstract：To estimate recent prevalence data (2011–2013) on traditional, complementary and alternative medicine (TCAM) provider use and sociodemographic and health related correlates in nationally representative population samples from 32 countries from all world regions. This secondary analysis was based on the International Social Survey Program (ISSP), 2011–2013, Health and Health Care Module. In a cross-sectional population-based survey (N=52,801), simple or multi-stage stratified random sampling was used, resulting in representative samples of the adult population of respective countries. Overall, the 12-month TCAM provider use prevalence was 26.4%, ranging from under 10% in Bulgaria, Poland and Slovenia to over 50% in China mainland, the Philippines and Republic of Korea. Over 80% TCAM treatment satisfaction was found in Europe in Denmark, Slovenia, Spain and Switzerland, in Asia in Taiwan (China) and USA. Multivariate logistic regression found sociodemographic variables (middle age, female sex, lower educational status, not having a religious affiliation, and lower economic indicators) and health variables (perceived poor or fair health status, being unhappy and depressed, having a chronic condition or disability, and having positive attitudes towards TCAM) were associated with TCAM provider use. A high prevalence TCAM provider use was found in all world regions and several sociodemographic and health related factors of its use were identified.  
        Keywords：utilization;traditional;Complementary Medicine;Africa;Asia;America;Australia;Europe   
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      • Gi Hee Jeong,William A. Boisvert,Mei-zhu Xi,Yi-lin Zhang,Young-Bin Choi,Sunghun Cho,Sanghyun Lee,Changsun Choi,Bog-Hieu Lee
        2018, 24(8): 591-599. DOI: 10.1007/s11655-017-2755-7
        Abstract：To investigate the hair growth-promoting effect of Miscanthus sinensis var. purpurascens (MSP) flower extracton on in vitro and in vivo models. MSP flower extract was extracted in 99.9% methanol and applied to examine the proliferation of human dermal papilla cells (hDPCs) in vitro at the dose of 3.92–62.50 μg/mL and hair growth of C57BL/6 mice in vivo at the dose of 1000 μg/mL. The expression of transforming growth factor β1 (TGF-β1), hepatocyte growth factor (HGF), β-catenin, substance P was measured by relative quantitative realtime polymerase chain reaction. Histopathological and immunohistochemical analysis were performed. MSP (7.81 μg/mL) down-regulated TGF-β1 and up-regulated HGF and β-catenin in hDPCs (P<0.01). MSP (1000 μg/mL)-treated mice showed the earlier transition of hair follicles from the telogen to the anagen phase. The number of mast cells was lower in the MSP-treated mice than in other groups (P<0.05 vs. NCS group). Substance P and TGF-β1 were expressed in hair follicles and skin of the MSP group lower than that in negative control. Stem cell factor in hair follicles was up-regulated in the MSP-treated mice (P<0.01). The MSP flower extract may have hair growth-promotion activities.  
        Keywords：Miscanthus sinensis var. purpurascens flower extract;hair growth;human hair dermal papilla cell;hepatocyte growth factor;transforming growth factor β1   
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        Published：2021-08-27
      • Shun-jin Hu,Bing Shu,Hua Jin,Xiao-feng Li,Jia-rong Mao,Ke-jun Ren,Lei Gao,Li Yang,You-wan Wu,Yong-jun Wang
        2018, 24(8): 600-605. DOI: 10.1007/s11655-016-2607-x
        Abstract：To evaluate the renal protective effect of Tangshenkang Granule (糖肾康颗粒) in a rat model of diabetic nephropathy (DN). Forty male Sprague-Dawley rats were randomly divided into control, DN, Tangshenkang and benazepril groups. DN model was established in the rats of DN, Tangshenkang and benazepril groups. Tangshenkang Granule solution and benazepril hydrochloride solution were intragastrically administered daily to the rats in the Tangshenkang and benazepril groups for 8 weeks, respectively. Urinary albumin and creatinine were detected. The albumin/creatinine (ACR) was calculated in addition to 24 h urinary protein (24-h UPr), serum creatinine (Scr), blood urea nitrogen (BUN), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and creatinine clearance rate (Ccr). Right kidneys were harvested for pathological observation using periodic acid-silver methenamine-Masson staining. The average glomerular diameter (DG), average glomerular (AG) and mesangial areas (AM) were measured. The thickness of glomerular basement membrane (TGBM) was detected using transmission electron microscope. Compared with rats in the control group, rats in the DN group showed significantly decreased body weight, increased hypertrophy index, 24-h urinary volume, 24-h UPr, ACR, Scr, BUN, Ccr, blood lipids as well as renal pathological indices including DG, AG, AM, AM/AG and TGBM (P <0.05). Compared with the DN group, the weights of rats in the Tangshenkang and benazepril groups were significantly increased, and the renal hypertrophy indices were significantly decreased (P <0.05). The 24-h urinary volumes, ACR, 24-h UPr, Scr, BUN, Ccr, LDL, DG, AG, AM and TGBM were obviously decreased (P <0.05). Compared with the benazepril group, the Tangshenkang group showed significantly decreased levels of ACR, 24-h UPr, AG and AM (P <0.05). Tangshenkang Granule decreased the urinary protein, attenuated the high glomerular filtration rate and improved lipid metabolism in DN rats, and prevented further injury induced by diabetic nephropathy.  
        Keywords：diabetic nephropathy;Tangshenkang Granule;kidney function;lipid metabolism;kidney pathology;Chinese Medicine   
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      • Fan Lin,Bin-ling Chen,Yi-zheng Wang,Dong Gao,Jun Song,T. J. Kaptchuk,Ke-ji Chen
        2018, 24(8): 606-612. DOI: 10.1007/s11655-015-2289-9
        Abstract：To compare the angiogenesis behaviors of vascular endothelial growth factor (VEGF) and Chinese medicine Xuefu Zhuyu Decoction (血府逐瘀汤, XZD) treatments. Human microvascular endothelial cells (HMEC-1) were treated with various concentrations of either XZD-containing serum (XZD-CS) or VEGF for 24, 48, and 72 h, respectively. Cell viability, proliferation, migration, adhesion, and in vitro tube formation assays were used to assess their angiogenic effects. VEGF promoted all cellular phases involved in angiogenesis including cell viability, proliferation, migration, adhesion, and tube formation (<0.05 or <0.01). Unlike the continuous promotion effects of VEGF at the above stages, XZD inhibited cell viability and proliferation (<0.05 or <0.01) and only promoted tube formation in the early phase of angiogenesis (<0.01). These two medications promote different angiogenesis behaviors, which might be an important reason for their distinct therapeutic profile in clinical usage.  
        Keywords：Xuefu Zhuyu Decoction;Chinese Medicine;vascular endothelial growth factor;angiogenesis   
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        Published：2021-08-27
      • Jian-yong Qi,Lei Wang,Dong-sheng Gu,Li-heng Guo,Wei Zhu,Min-zhou Zhang
        2018, 24(8): 613-620. DOI: 10.1007/s11655-016-2448-7
        Abstract：To observe the in vivo effect of Danlou Tablet (丹蒌片, DLT) on myocardial ischemia and reperfusion (I/R) injury. DLT effects were evaluated in mouse heart preparation using 30-min coronary occlusion followed by 24-h reperfusion and compared among sham group (n=6), I/R group (n=8), IPC group (ischemia preconditioning, n=6) and DLT group (I/R with DLT pretreatment for 3 days, 750 mg•kg-1•day-1, n=8). The effects of DLT were characterized in infarction size (IS) compared with risk region (RR) and left ventricle using the Evans blue/triphenyltetrazolium chloride double dye staining method in vivo. Furthermore, the dose-dependent effect of DLT on I/R injury was evaluated by double staining method. Five different concentrations of DLT (0.625, 1.25, 2.5, 5 and 10 g•kg-1•day-1) were chosen in this study, and dose-response curve of DLT was obtained on these data. The ratio of IS to left ventricle was significantly smaller in the DLT and IPC groups than the I/R group (P<0.05 or P<0.01), the ratio of IS to RR was also reduced in the DLT and IPC groups (P<0.01), while there were no differences in RR among the four groups (P>0.05). Experiments showed incidence of arrhythmias was reduced in the DLT group (P<0.01). Furthermore, DLT produced a dose-dependent inhibitory effect with a half maximal inhibitory concentration of 1.225 g•kg-1•day-1. Our research concluded that DLT was effective in reducing I/R injury in mice, and provided experimental supports for the clinical use of DLT.  
        Keywords：ischemia and reperfusion;Chinese Medicine;Danlou Tablet   
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        Published：2021-08-27
      • Byung Il Yoon,Woong Jin Bae,Yong Sun Choi,Su Jin Kim,U. Syn Ha,Sung-Hoo Hong,Dong Wan Sohn,Sae Woong Kim
        2018, 24(8): 621-626. DOI: 10.1007/s11655-013-1547-y
        Abstract：To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis (CBP) rat model. The Sprague-Dawley rats were divided into 4 groups, including control, ciprofloxacin, anthocyanins and anthocyanins with ciprofloxacin groups (n=8 in each group). Then, drip infusion of bacterial suspension (Escherichia coli Z17 O2:K1:H−) into Sprague-Dawley rats was conducted to induce CBP. In 4 weeks, results of prostate tissue, urine culture, and histological analysis on the prostate were analyzed for each group. Results: The use of ciprofloxacin, anthocyanins, and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group (P<0.05). The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group (P<0.05). These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects, as well as a synergistic effect with ciprofloxacin. Therefore, we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.  
        Keywords：Prostatitis;anti-bacterial agents;anthocyanins   
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      • Yan-qing Tong,Min Sun,Chun-jie Hu,Dong-kai Zhao
        2018, 24(8): 627-631. DOI: 10.1007/s11655-016-2599-6
        Abstract：To observe the alteration of QT dispersion (QTd) and QTc dispersion (QTcd) in hemodialysis patients after oral administration of Zhigancao Decoction (炙甘草汤, Roasted Licorice Decoction, RLD). To investigate the alteration of QTd and QTcd in 68 routine hemodialysis patients before and after hemodialysis with 12-lead electrocardiogram (ECG) after orally administrated RLD for 4 weeks. Blood was also taken for measurement of plasma electrolytes, liver function, renal function, hemoglobin (Hgb) and hematocrit (HCT). After hemodialysis, QTd and QTcd were prolonged evidently; the difference was significant between before and after hemodialysis (P<0.05). After RLD orally administrated for 4 weeks, QTd and QTcd only slightly increased after dialysis compared with pre-dialysis (P>0.05). The QTd and QTcd of the post-therapy-post-dialysis decreased significantly compared with the pre-therapy-post-dialysis (P<0.05). There were no other significant changes in other variables (post-therapy-pre-dialysis vs. pre-therapy-pre-dialysis, or post-therapy-post-dialysis vs. pre-therapy-post-dialysis;P>0.05). After therapy, the number of patients with supraventricular arrhythmia, occasional ventricular premature beat and multiple ventricular premature beat were decreased from 15 to 4, 10 to 2 and 7 to 1, respectively. RLD therapy not only lowered the increased QTd and QTcd after hemodialysis, but also displayed a safety profile.  
        Keywords：chronic renal failure;QT dispersion;hemodialysis;roasted licorice decoction;Chinese Medicine   
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        Published：2021-08-27

        ReviewPaper

      • Ying Zhang,Xiao-juan Ma,Da-zhuo Shi
        2018, 24(8): 632-640. DOI: 10.1007/s11655-015-2297-9
        Abstract：Atherothrombosis is the major cause of acute coronary syndromes and cardiovascular deaths. Platelets participate in the processes of forming and extending atherosclerotic plaques. Therefore, antiplatelet therapy is a milestone in the primary and second prevention of atherothrombotic diseases. Along with the longterm use of antiplatelet agents, the safety and drug resistance has become a big concern in clinic and new drugs possessing higher effectiveness and fewer adverse effects are needed. Abundant recent data support that traditional Chinese herbs may be a good alternative and complementary choice of new antiplatelet drugs. This review highlights the progress of antiplatelet effect of active components derived from traditional Chinese herbs based on their chemical structures.  
        Keywords：Chinese Herbal Medicine;antiplatelet;active components   
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