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Latest Issue
2025Year31Volume11Issue
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Original Article
Effect and Safety of Phytosomal Curcumin Supplementation on Migraine Patients: A Randomized, Double-Blind and Placebo-Controlled Trial
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2025, 31(11): 963-972. DOI: 10.1007/s11655-025-3939-1
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Updated:2025-10-23
藏红花素通过调节APP加工、抑制内质网应激及激活自噬作用抑制N2a/APP细胞中Aβ生成
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2025, 31(11): 973-981. DOI: 10.1007/s11655-025-3933-7
Abstract:目的:探讨藏红花主要活性成分藏红花素调节神经元细胞中β淀粉样蛋白(Aβ)生成、内质网应激及自噬的作用机制,为阿尔茨海默病(AD)治疗提供潜在靶点。方法:采用具有稳定过表达APP瑞典突变(APPswe)的N2A神经细胞(N2a/APP)作为AD细胞模型,空载转染细胞(N2a/vector)作为对照。通过流式细胞术评估三种浓度藏红花素对活性氧(ROS)、胞内钙离子及细胞凋亡的影响;酶联免疫吸附法检测Aβ水平;蛋白质免疫印迹法分析APP加工过程及内质网应激相关蛋白表达;自噬检测试剂盒联合共聚焦显微镜观察自噬体形成。结果:藏红花素可抑制N2a/APP细胞中APP表达,促进APP加工的α剪切途径,同时适度降低β分泌酶1(BACE1)及早老素1(PS1)水平(P<0.05或P<0.01)。与对照组相比,N2a/APP细胞内质网应激标志蛋白(Bip/GRP78、CHOP)显著升高(P<0.05),藏红花素能有效逆转该趋势(P<0.05或P<0.01)。此外,藏红花素通过促进自噬体形成增强自噬活性(P<0.05或P<0.01)。结论:藏红花素通过促进APPα剪切、抑制内质网应激相关未折叠蛋白反应及调控自噬通路,显著抑制Aβ生成。
Keywords:阿尔茨海默病;淀粉样前体蛋白加工;自噬;藏红花素;内质网应激;未折叠蛋白反应
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Updated:2025-10-23
Suanzaoren Decoction Alleviates Anxiety- and Depression-Like Behaviors Induced by Chronic Restraint Stress via Regulating Pyramidal Neuron Activity in Basolateral Amygdala of Mice
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2025, 31(11): 982-990. DOI: 10.1007/s11655-025-3942-6
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Updated:2025-10-23
Dihuang Yinzi Regulates cAMP/PKA/CREB-BDNF to Improve Synaptic Plasticity in APP/PS1 Mice: A Study Based on Brain Metabolomics
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2025, 31(11): 991-1000. DOI: 10.1007/s11655-025-3936-4
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Updated:2025-10-23
Liujunzi Decoction Regulated Intestinal Flora Homeostasis to Relieve Lung–Gut Axis Inflammation in Asthma Flora Disorder Mice: Possibly Related to GATA3/ILC2
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2025, 31(11): 1001-1010. DOI: 10.1007/s11655-025-3929-3
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Updated:2025-10-23
Quercetin Confers Protection against Sepsis-Related Acute Respiratory Distress Syndrome by Suppressing ROS/p38 MAPK Pathway
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2025, 31(11): 1011-1020. DOI: 10.1007/s11655-025-3927-5
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Updated:2025-10-23
Salvianolic Acid B Exerts Antiphotoaging Effect on Ultraviolet B-Irradiated Human Keratinocytes by Alleviating Oxidative Stress via SIRT1 Protein
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2025, 31(11): 1021-1028. DOI: 10.1007/s11655-025-3931-9
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Updated:2025-10-23
Clinical Experience
Lu'e Biyan Formula for Treatment of Allergic Rhinitis Patients with Fei (Lung)-Qi Deficiency-Coldness Syndrome: A Randomized, Double Blind, and Placebo-Controlled Trial
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2025, 31(11): 1029-1036. DOI: 10.1007/s11655-025-3948-0
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Updated:2025-10-23
Review
甲型流感的中医治疗策略:研究进展与展望
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2025, 31(11): 1037-1045. DOI: 10.1007/s11655-025-3941-7
Abstract:本综述总结并阐述了甲型流感的流行病学与治疗现状,以及其中医治疗的基础与临床研究。此外,本综述探讨了多组学等新兴技术在中医治疗甲型流感中的潜在应用及面临的挑战。研究成果有望为甲型流感发病机制提供新见解,并从中医角度为新型抗甲型流感病毒药物研发提供依据。
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Updated:2025-10-23
中医药在糖尿病视网膜病变中的优势及机制:聚焦于炎症与氧化应激
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2025, 31(11): 1046-1055. DOI: 10.1007/s11655-025-3938-2
Abstract:糖尿病性视网膜病变(DR)作为全球视力障碍的主要诱因,其患病率呈持续上升趋势。尽管现有的眼部治疗和血糖控制等治疗手段已广泛应用,仍难以有效应对这一多维度疾病。慢性炎症反应与氧化应激互为因果,触发病理级联反应,是DR发生发展的关键病理环节。中药凭借多靶点和整体调节的独特优势,其抗炎和抗氧化的双重活性已得到初步验证,然而,二者协同效应及在DR中的整合机制尚未得到系统阐明。为此,本文综述中药复方、中成药、草药及其活性成分通过抗炎和抗氧化途径干预DR的研究进展,旨在阐明其作用机制,为深入理解中药综合调控DR的分子基础及临床防治提供新思路。
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Updated:2025-10-23
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