Supported by Key Program of National Natural Science Foundation of China (No. 81330084), National Science and Technology Major Special Project (No. 2012ZX10005001-004), National Key Research and Development: Special Project for Research on the Modernization of Traditional Chinese Medicine (No. 2018YFC1704204) and Science and Technology Commission of Shanghai Municipality (No.19YF1449900),Conflict of Interest,The authors declare that they have no conflict of interests.,Author Contributions,Su SB designed the study and revised the article. Hu YY collected the CHB samples in clinical. Hu XQ conducted the experiments, performed the analyses and wrote the manuscript. Chen J helped to draw the figures. Lu YY conducted the cytokines detection. Zhou Y and Chen QL offered suggestions for experiment performing and data analyses.