Supported by the Natural Science Foundation of Fujian Province, China (No. 2019J01355) and Xiamen Traditional Chinese Medicine Factory Co., Ltd. (No. HX2016001),Conflict of Interest,The authors declare that they have no conflict of interest. There is no any interest with Xiamen Traditional Chinese Medicine Factory.,Author Contributions,Lin JM and Peng J designed the study; Chen X participated in the paper preparation. Gui MX and Huang B performed the experiments, wrote the paper and contributed equally to this paper. Gui MX, Huang B and Gao Y analyzed the data. Muthu R and Wang RG contributed to paper writing and careful review. All authors read and approved the final manuscript for publication.