Conflict of Interest,The authors have no financial or commercial conflicts of interest to declare.,Author Contributions,Wan HT and Yang JH designed the experiments. Wang HY, Zhou HF and He Y perform the experiments. Yu L and Li C analyzed the data. Wang HY wrote the manuscript. Wang HT and Yang JH supervise the whole experimental process and the preparation of the manuscript. All authors read and approved the final manuscript for publication.,Supported by the National Natural Science Foundation of China (No. 81630105, 81973560); Zhejiang Provincial Natural Science Foundation of China (Nos. LZ17H270001 and LZ18H270001) and Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents