Supported by the National Natural Science Foundation of China (No. 81273933 and 81102722), the Eleven Five-Year Plan of National Science and Technology Support Project (No. 2006BAI04A01-2), the Jilin Province Major Science and Technology Achievement Transforming Project (No. 11ZDZH005),Conflict of Interest,The authors declare no competing financial interests.,Author Contributions,Prof. Shi DZ and Dr. Jiang HY have made substantial intellectual contributions to the conception and design of this study, with revising and final approve of the article. Wang MM has contributed to the experiment conduction and data analysis of this study, and the article drafting. Assoc. Prof. Xue M has contributed to the drug material supply and blood sampling and FACS procession. Dr. Xin ZH has contributed to the data analysis. Dr. Li RJ and Wang YH have made substantial contribution to the language revision. All the authors approve the submission and publication of the manuscript.