Supported by the State Administration of Traditional Chinese Medicine (No. 201307004),Conflict of Interests,The authors declare no conflict of interests.,Author Contributions,Su YX and Guo JM conceived of and designed the study. Zhu YJ, Zhang YQ, Lai XQ and Huang LL were responsible for recruiting patients. Cai TY, Wang JH, Chen SQ and Li BL were responsible for clinical data collection. Xiao Y and Mao X provided efforts in data analysis. All authors participated in the writing and/or critical revision of the manuscript and approved the final version for submission.