Conflict of Interest,The authors declare no financial or commercial conflict of interest.,Supported by National Science and Technology Major Project of the Ministry of Science and Technology of China (No. 2017ZX09304025), Construction Program of Clinical Cooperation Ability of Chinese and Western Medicine for Major and Difficult Diseases (No. 2019-163), the Key Research and Development Program of Liaoning Province (No. 2018225060), Science and Technology Plan Project of Liaoning Province (No. 2016007010), and Science and Technology Plan Project of Shenyang City (No. 19-112-4-099)