Conflict of Interest,All authors declare that: (1) no support, financial or otherwise, has been received from any organization that may have an interest in the submitted work; (2) there are no other relationships or activities that could appear to have influenced the submitted work.,Supported by Research Foundation of Chinese Medicine Program of Zhejiang Province (No. 2015ZA211), National Major Project for the Innovative New Drugs of “the 13th Five-Year Plan” (No. 2016ZX09101071)