Supported by the National Science Foundation of China (No. 81704097), “Sailing Program” of the Shanghai Science and Technology Committee (No. 19YF1449600), and the “Yumiao Project” of Longhua Hospital affiliated to Shanghai University of Chinese Medicine (No. LYTD-60),Conflict of Interest,The authors declare that they have no competing interests.,Author Contributions,Yin MC, Wang HS and Yang X contributed to the design. Yan YJ and Fan ZX collected the studies. Yin MC, Xin CQ and Wang T drafted the manuscript. Ye J and Ma JM participated in the statistical analysis. Mo W revised the manuscript. All authors read and approved the final manuscript.,Availability of Data and Material,The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.