Supported by the China Postdoctoral Science Foundation (No. 2019M651044), and the National Natural Science Foundation of China (No. 81330088),Conflict of Interest,The authors declare that they have no competing interest.,Author Contributions,Zhang K, Yang T, Zhang YF and Yan YW carried out the experiments, Zhang K, Yang T and Zhang YF contributed to statistical analysis, Zhang K, Zhao X, Xu ZF, Gong YN, Liu YY wrote the manuscript, Guo Y, Guo YM and Zhao X designed the project and supervised the work and provided the facilities for the study. All authors read the manuscript and approved the final version.