Supported by National Natural Science Foundation of China (No. 81703932), Beijing Natural Science Foundation (No. 7144205), The Youth Talent Fund of Beijing Municipal Bureau of Health Administration Grants (No. QML20190605), Beijing Science and Technology Development Fund Project of Traditional Chinese Medicine (No.JJ-2020-01), and Science and Technology Plan of Chaoyang District, Beijing (No. CYSF2027),Conflict of Interest,The authors have no financial associations or any other conflicts of interests to declare.,Author Contributions,The authors acknowledge the invaluable participation of participants. Feng Y prepared and drafted the manuscript. Wang LY, Wang YX, and Xu H provided constructive suggestions and modified the manuscript. Lu SL and Jin XG performed the statistical analysis for this article. Gao J and Chen WP provided the data for this manuscript.