Supported by the National Natural Science Foundation of China (No. 82074450), Natural Science Foundation of Hunan Province (No. 2020JJ4066), Postgraduate Innovation Project of Hunan University of Chinese Medicine in 2020 (No. 2020CX14), “YIFANG” Postgraduate Innovation Project of Hunan University of Chinese Medicine (No. 2020YF04),Conflict of Interest,The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.,Author Contributions,Zhang Z and Zeng PH contributed to the conception of this manuscript and wrote the draft; Tian XF contributed to this manuscript revision, the data collection and funding; Gao WH and Li JW helped with revision; All authors read and approved the final manuscript.,Data Availability Statement,The datasets generated and/or analyzed during the study are not publicly available to protect subject confidentiality but are available from the corresponding author on reasonable request.