Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers

Xiao Yi; Huang Xi-zhen; Zhu Jia-shi

doi:10.1007/BF02836405

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Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers

Updated：2021-08-27

- Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers
- Chinese Journal of Integrative Medicine Vol. 10, Issue 3, Pages: 187-192(2004)
- Affiliations：
  
  Department of Respiratory Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/BF02836405
  CLC：
- Published：2004，
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Yi, X., Xi-zhen, H. & Jia-shi, Z. Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers., Chin. J. Integr. Med. 10, 187–192 (2004). https://doi.org/10.1007/BF02836405

Xiao Yi, Huang Xi-zhen, Zhu Jia-shi. Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers. [J]. Chinese Journal of Integrative Medicine 10(3):187-192(2004)
Yi, X., Xi-zhen, H. & Jia-shi, Z. Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers., Chin. J. Integr. Med. 10, 187–192 (2004). https://doi.org/10.1007/BF02836405 DOI：

Xiao Yi, Huang Xi-zhen, Zhu Jia-shi. Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers. [J]. Chinese Journal of Integrative Medicine 10(3):187-192(2004) DOI： 10.1007/BF02836405.

摘要

Objective: Cordyceps sinensis (CS) is a popular natural Chinese herbal medicine for invigoration

health preservation and reducing fatigue. Its natural substance has been prepared as a fermentation product of a specific strain of Cordyceps sinensis (Cs-4). Our objective was to assess the effect of Cs-4 on the exercise capacity of the healthy elderly people in a randomized

double-blind

placebo-controlled trial.Methods: Thirty-seven healthy

elderly Chinese subjects were randomly assigned to receive either Cs-4 (3 g/ day) or identical placebo capsules. Their exercise performance was tested before and after 6 weeks of treatment with a symptom-limited

incremental work rate protocol on a cycle ergometer. Maximum oxygen uptake (VO2max) was measured using a metabolic chart. Anaerobic thresholds (VO2θ) were identified by two observers using plots of both VCO2 vs VO2 and VE/VO2 vs time.Results: After taking Cs-4 for 6 weeks

VO2max (1.88 ±0.13 to 2.00 ±0.14 L/min;P = 0.050) and VO2θ (1.15 ±0.07 to 1.30 ±0.09 L/min;P = 0.012) were significantly increased

whereas after placebo application they were unchanged.Conclusion: These findings support the belief held in China that Cs-4 could improve oxygen uptake or aerobic capacity and ventilation function and resistance to fatigue of elderly people in exercise.

Abstract

Objective: Cordyceps sinensis (CS) is a popular natural Chinese herbal medicine for invigoration

double-blind

placebo-controlled trial.Methods: Thirty-seven healthy

VO2max (1.88 ±0.13 to 2.00 ±0.14 L/min;P = 0.050) and VO2θ (1.15 ±0.07 to 1.30 ±0.09 L/min;P = 0.012) were significantly increased

关键词

Cordyceps sinensisCs-4aerobic capacityventilationelderlyexercise

Keywords

Cordyceps sinensisCs-4aerobic capacityventilationelderlyexercise

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Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

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