Effects of Tribuli saponins on left ventricular remodeling after acute myocardial infarction in rats with hyperlipidemia

Guo Yan; Yin Hui-jun; Shi Da-zhuo; Chen Ke-ji

doi:10.1007/BF02836472

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Effects of Tribuli saponins on left ventricular remodeling after acute myocardial infarction in rats with hyperlipidemia

Updated：2021-08-27

- Effects of Tribuli saponins on left ventricular remodeling after acute myocardial infarction in rats with hyperlipidemia
- Chinese Journal of Integrative Medicine Vol. 11, Issue 2, Pages: 142-146(2005)
- Affiliations：
  
  Xiyuan Hospital, China Academy of Traditional Chinese Medicine,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02836472
  CLC：
- Published：2005，
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Yan, G., Hui-jun, Y., Da-zhuo, S. et al. Effects of Tribuli saponins on left ventricular remodeling after acute myocardial infarction in rats with hyperlipidemia., Chin. J. Integr. Med. 11, 142–146 (2005). https://doi.org/10.1007/BF02836472

Guo Yan, Yin Hui-jun, Shi Da-zhuo, et al. Effects of Tribuli saponins on left ventricular remodeling after acute myocardial infarction in rats with hyperlipidemia. [J]. Chinese Journal of Integrative Medicine 11(2):142-146(2005)
Yan, G., Hui-jun, Y., Da-zhuo, S. et al. Effects of Tribuli saponins on left ventricular remodeling after acute myocardial infarction in rats with hyperlipidemia., Chin. J. Integr. Med. 11, 142–146 (2005). https://doi.org/10.1007/BF02836472 DOI：

Guo Yan, Yin Hui-jun, Shi Da-zhuo, et al. Effects of Tribuli saponins on left ventricular remodeling after acute myocardial infarction in rats with hyperlipidemia. [J]. Chinese Journal of Integrative Medicine 11(2):142-146(2005) DOI： 10.1007/BF02836472.

摘要

Objective: To observe the effect of Tribuli saponins (TS) on left ventricular remodeling after acute myocardial infarction (AMI) in rats with hyperlipemia.Methods: A composite model of myocardial infarction and hyperlipemia was established and treated with TS to observe its effect on cardiac structure and function by echocardiography.Results: (1) Cardiac function: As compared with the model group

the fractional shortening (FS) and ejection fraction (EF) got increased

and the left ventricular end diastolic volume (LVEDV) and systolic volume (LVESV) got lower in the groups treated with high dose TS and simvastatin (P<0.05 orP<0.01)

but difference between the two treated groups was insignificant. (2) Cardiac structure: As compared with the model group

the left ventricular dimension end diastole (LVDd) and systole (LVDs) in the groups treated with high dose TS and simvastatin got lower (P<0.05 orP<0.01). No treatment showed any effect on the thickness of ventricular wall. (3)Ventricular weight index: Both high dose TS and simvastatin could decrease the left ventricular weight index (LVWI) (P<0.05).Conclusion: TS could attenuate the left ventricular remodeling after acute myocardial infarction to certain extent

and improve cardiac function in the early phase after AMI

thus playing an important role in controlling morbidity and mortality of cardiac events and long-term prognosis.

Abstract

the fractional shortening (FS) and ejection fraction (EF) got increased

and the left ventricular end diastolic volume (LVEDV) and systolic volume (LVESV) got lower in the groups treated with high dose TS and simvastatin (P<0.05 orP<0.01)

but difference between the two treated groups was insignificant. (2) Cardiac structure: As compared with the model group

and improve cardiac function in the early phase after AMI

thus playing an important role in controlling morbidity and mortality of cardiac events and long-term prognosis.

关键词

Tribuli saponinsventricular remodelinghyperlipemiaacute myocardial infarction

Keywords

Tribuli saponinsventricular remodelinghyperlipemiaacute myocardial infarction

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Division of Emergency, the Second Clinical College of Guangzhou University of Traditional Chinese Medicine

The Second Hospital of Hebei Medical University

Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Heart Center, Guangdong Provincial Hospital of Chinese Medicine

Department of Internal Cardiac Medicine, Tongren Hospital Affiliated to the Capital Medical University

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