Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy

Xu-sheng Li; Wei-ying Zheng; Shi-xian Lou; Xiao-wen Lu; Shang-he Ye

doi:10.1007/s11655-009-0026-8

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Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy

Updated：2021-08-27

- Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy
- Chinese Journal of Integrative Medicine Vol. 15, Issue 1, Pages: 26-29(2009)
- Affiliations：
  
  1. Medical College, Jinhua College of Profession and Technology,Jinhua,China
  2. The Affiliated Hospital of Jinhua College of Profession and Technology,Jinhua,China
- Author bio：
- Funds：
  
  Supported by the Scientific Research Grant of Zhejiang Provincial Administration Bureau of Education (No. 20051319)
- DOI：10.1007/s11655-009-0026-8
  CLC：
- Published：2009，
  
  Published Online：7 March 2009，
Scan for full text
Li, Xs., Zheng, Wy., Lou, Sx. et al. Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy., Chin. J. Integr. Med. 15, 26–29 (2009). https://doi.org/10.1007/s11655-009-0026-8

Xu-sheng Li, Wei-ying Zheng, Shi-xian Lou, et al. Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy. [J]. Chinese Journal of Integrative Medicine 15(1):26-29(2009)
Li, Xs., Zheng, Wy., Lou, Sx. et al. Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy., Chin. J. Integr. Med. 15, 26–29 (2009). https://doi.org/10.1007/s11655-009-0026-8 DOI：

Xu-sheng Li, Wei-ying Zheng, Shi-xian Lou, et al. Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy. [J]. Chinese Journal of Integrative Medicine 15(1):26-29(2009) DOI： 10.1007/s11655-009-0026-8.

摘要

To explore the effect of ginkgo leaf extract (GLE) on vascular endothelial function (VEF) in patients with early stage diabetic nephropathy (DN). Sixty-four patients were randomized equally by a randomzing digital table into two groups

the treated group and the control group. They were all treated for 8 weeks with conventional therapy for diabetes

but GLE tablets were given to the treated group additionally. Changes in VEF were estimated before and after treatment by ultrasonic examination of the brachial artery. In the meantime

changes in plasma levels of the von Willebrand factor (vWF)

nitric oxide (NO) and endothelin-1 (ET-1) were observed as well. The brachial arterial endothelium dependent dilating function in the treated group increased from 4.91±2.31% before treatment to 6.78±3.89% after treatment (P<0.05)

while the level of vWF decreased from 182.05±64.13% to 128.56±48.98%

and that of NO increased from 50.16±24.64 μmol/L to 70.65±28.71 μmol/L (P<0.01). However

these indexes were not significantly changed in the control group after treatment (P>0.05). GLE could decrease the plasma level of vWF

raise the plasma NO level and improve the endothelium dependent vascular dilating function in DN patients.

Abstract

the treated group and the control group. They were all treated for 8 weeks with conventional therapy for diabetes

but GLE tablets were given to the treated group additionally. Changes in VEF were estimated before and after treatment by ultrasonic examination of the brachial artery. In the meantime

changes in plasma levels of the von Willebrand factor (vWF)

while the level of vWF decreased from 182.05±64.13% to 128.56±48.98%

and that of NO increased from 50.16±24.64 μmol/L to 70.65±28.71 μmol/L (P<0.01). However

these indexes were not significantly changed in the control group after treatment (P>0.05). GLE could decrease the plasma level of vWF

raise the plasma NO level and improve the endothelium dependent vascular dilating function in DN patients.

关键词

Ginkgo leaf extractdiabetic nephropathyendothelial functionvon Willebrand factor

Keywords

Ginkgo leaf extractdiabetic nephropathyendothelial functionvon Willebrand factor

references

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Department of Pharmacy, College of Chemical and Chemistry Engineering, Hu’nan University

Department of Basic Guiyang College of Traditional Chinese Medicine

Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of Technology

Zhejiang University of Traditional Chinese Medicine

Dongzhimen Hospital, Beijing University of Chinese Medicine

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