Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on microenvironment of ova in patients with endometriosis

Fang Lian; Xin-ling Li; Zhen-gao Sun; Jian-wei Zhang; Yan-he Liu; Feng-mei Ma

doi:10.1007/s11655-009-0042-8

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Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on microenvironment of ova in patients with endometriosis

Updated：2021-08-27

- Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on microenvironment of ova in patients with endometriosis
- Chinese Journal of Integrative Medicine Vol. 15, Issue 1, Pages: 42-46(2009)
- Affiliations：
  
  1. Reproductive and Genetic Center of Intrgrative Medivine, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,China
  2. Clinical College, Shandong University of Traditional Chinese Medicine,Jinan,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30672706)
- DOI：10.1007/s11655-009-0042-8
  CLC：
- Published：2009，
  
  Published Online：7 March 2009，
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Lian, F., Li, Xl., Sun, Zg. et al. Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on microenvironment of ova in patients with endometriosis., Chin. J. Integr. Med. 15, 42–46 (2009). https://doi.org/10.1007/s11655-009-0042-8

Fang Lian, Xin-ling Li, Zhen-gao Sun, et al. Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on microenvironment of ova in patients with endometriosis. [J]. Chinese Journal of Integrative Medicine 15(1):42-46(2009)
Lian, F., Li, Xl., Sun, Zg. et al. Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on microenvironment of ova in patients with endometriosis., Chin. J. Integr. Med. 15, 42–46 (2009). https://doi.org/10.1007/s11655-009-0042-8 DOI：

Fang Lian, Xin-ling Li, Zhen-gao Sun, et al. Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on microenvironment of ova in patients with endometriosis. [J]. Chinese Journal of Integrative Medicine 15(1):42-46(2009) DOI： 10.1007/s11655-009-0042-8.

摘要

To observe the effect of Quyu Jiedu Granules (祛瘀解毒颗粒

QJG) on the micro- microenvironment of ova in patients with endometriosis (EM). environment Twenty EM patients who received in vitro fertilization and embryo transfer (IVF-ET) were randomized equally into a treated group and a control group. Further

20 patients who received IVF-ET due to oviduct factors were enrolled into a non-endometriosis group. The dosage of gonadotrophic hormone used

the number of ova attained

fertilization rate and clinical pregnancy rate were all observed

and the levels of tumor necrosis factor α (TNF-⇌) and interleukin 6 (IL-6) in follicular fluid as well as their mRNA expressions in ovarian granular cells were detected by RT-PCR on the very day of ovum attainment. The ova attainment (13.80±6.87) and fertilization rate (0.69±0.31) in the treated group were all higher than the corresponding values in the control group (9.80±5.32 and 0.47±0.22); the follicular fluid contents of TNF-α and IL-6 in the treated group were 1.38±0.21 ng/mL and 130.56±12.81 pg/mL

respectively

which were lower than those in the control group (1.98±0.34 ng/mL and 146.83±17.65 pg/mL

respectively). Further

the treated group showed much lower mRNA expressions of TNF-α and IL-6 in ovarian granular cells. The elevation of TNF-α and IL-6 contents in follicular fluid and their mRNA expressions in ovarian granular cells are possibly related to the low quality of ova in EM; QJG might raise the ova quality by reducing TNF-α and IL-6 levels to improve the living micro-environment for the ova.

Abstract

To observe the effect of Quyu Jiedu Granules (祛瘀解毒颗粒

20 patients who received IVF-ET due to oviduct factors were enrolled into a non-endometriosis group. The dosage of gonadotrophic hormone used

the number of ova attained

fertilization rate and clinical pregnancy rate were all observed

respectively

which were lower than those in the control group (1.98±0.34 ng/mL and 146.83±17.65 pg/mL

respectively). Further

关键词

endometriosisQuyu Jiedu Granulein vitro fertilizationfollicular fluidgranular cellstumor necrosis factor αinterleukin 6

Keywords

endometriosisQuyu Jiedu Granulein vitro fertilizationfollicular fluidgranular cellstumor necrosis factor αinterleukin 6

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Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology

Department of Emergency Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences

Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

Department of Obstetrics and Gynecology, Beijing Hospital, Ministry of Health

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