Influence of TCM therapy for supplementing Pi (脾) and nourishing Shen (肾) on dendritic cell function in patients with chronic hepatitis B treated by lamivudine

Yong-hua Zhang; Yi-hui Liu

doi:10.1007/s11655-009-0060-6

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Influence of TCM therapy for supplementing Pi (脾) and nourishing Shen (肾) on dendritic cell function in patients with chronic hepatitis B treated by lamivudine

Updated：2021-08-27

- Influence of TCM therapy for supplementing Pi (脾) and nourishing Shen (肾) on dendritic cell function in patients with chronic hepatitis B treated by lamivudine
- Chinese Journal of Integrative Medicine Vol. 15, Issue 1, Pages: 60-62(2009)
- Affiliations：
  
  Department of Hepatopathy, Zhejiang Hospital of Integrated Traditional and Western Medicine,Hangzhou,China
- Author bio：
- Funds：
  
  Supported by General Scientific Research Development Projects of Science and Technology Department of Zhejiang Province (No. 2006C33007)
- DOI：10.1007/s11655-009-0060-6
  CLC：
- Published：2009，
  
  Published Online：7 March 2009，
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Zhang, Yh., Liu, Yh. Influence of TCM therapy for supplementing Pi (脾) and nourishing Shen (肾) on dendritic cell function in patients with chronic hepatitis B treated by lamivudine., Chin. J. Integr. Med. 15, 60–62 (2009). https://doi.org/10.1007/s11655-009-0060-6

Yong-hua Zhang, Yi-hui Liu. Influence of TCM therapy for supplementing Pi (脾) and nourishing Shen (肾) on dendritic cell function in patients with chronic hepatitis B treated by lamivudine. [J]. Chinese Journal of Integrative Medicine 15(1):60-62(2009)
Zhang, Yh., Liu, Yh. Influence of TCM therapy for supplementing Pi (脾) and nourishing Shen (肾) on dendritic cell function in patients with chronic hepatitis B treated by lamivudine., Chin. J. Integr. Med. 15, 60–62 (2009). https://doi.org/10.1007/s11655-009-0060-6 DOI：

Yong-hua Zhang, Yi-hui Liu. Influence of TCM therapy for supplementing Pi (脾) and nourishing Shen (肾) on dendritic cell function in patients with chronic hepatitis B treated by lamivudine. [J]. Chinese Journal of Integrative Medicine 15(1):60-62(2009) DOI： 10.1007/s11655-009-0060-6.

摘要

To observe the influence of traditional Chinese medicine (TCM) therapy for supplementing Pi (脾) and nourishing Shen (肾

SPNS) on dendritic cell function in patients with chronic hepatitis B (CHB) treated by lamivudine. Sixty CHB patients with positive HBeAg were equally randomized by digital table into two groups: the observation group and the control group. Patients in the control group were treated with lamivudine only

while patients in the observation group were treated with lamivudine combined with SPNS fomula

for 12 weeks. The phenotype and function of dendritic cell

as well as its secretion factor interleukin 12 (IL-12) in all patients were determined after termination of therapy and the impacts on alanine transaminase (ALT) and HBVDNA were observed. The phenotypes of dendritic cells such as CD1a

CD80

CD86

human leukocyte antigen (HLA-DR) and intercellular adhesion molecule-1

as well as the levels of stimulation index (SI) and IL-12 were higher in the observation group than those in the control group (P<0.05 or P<0.01). Meanwhile

signififi cant difference between the two groups was also shown in the normalizing rates of ALT and HBV-DNA (P<0.05). TCM therapy for SPNS can signifificantly improve the function of dendritic cells in patients with CHB treated by lamivudine and enhance the early stage response of patients to the treatment.

Abstract

To observe the influence of traditional Chinese medicine (TCM) therapy for supplementing Pi (脾) and nourishing Shen (肾

while patients in the observation group were treated with lamivudine combined with SPNS fomula

for 12 weeks. The phenotype and function of dendritic cell

CD80

CD86

human leukocyte antigen (HLA-DR) and intercellular adhesion molecule-1

as well as the levels of stimulation index (SI) and IL-12 were higher in the observation group than those in the control group (P<0.05 or P<0.01). Meanwhile

关键词

TCM therapy for supplementing Pi and nourishing ShenLamivudinechronic hepatitis Bdendritic cells

Keywords

TCM therapy for supplementing Pi and nourishing ShenLamivudinechronic hepatitis Bdendritic cells

references

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Jiangyin Hospital Affiliated to Medical College of South Eastern University

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Institute of Basic Theories of Traditional Chinese Medicine, China Academy of Traditional Chinese Medicine

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