Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction

Guo-qiang Yuan; Zhen-hua Jia; Hai-tao Yang; Shi-zhen Wu; Huai-lin Gao; Cong Wei; Hui-ming Zhu; Yi-ling Wu

doi:10.1007/s11655-010-0054-7

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Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction

Updated：2021-08-27

- Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction
- Chinese Journal of Integrative Medicine Vol. 16, Issue 1, Pages: 54-60(2010)
- Affiliations：
  
  1. The Laboratory of Collateral Diseases, Pharmaceutical Research Academy, Hebei Medical University,Shijiazhuang,China
  2. The Laboratory of Epidemiology and Health Statistics, Public Health Institute, Hebei Medical University,Shijiazhuang,China
- Author bio：
- Funds：
  
  Supported by the National Basic Research Program of China (973 Program, No. 2005CB523301), the International Science and Technology Cooperation Program (No. 2006DFB32460)
- DOI：10.1007/s11655-010-0054-7
  CLC：
- Published：2010，
  
  Published Online：4 February 2010，
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Yuan, Gq., Jia, Zh., Yang, Ht. et al. Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction., Chin. J. Integr. Med. 16, 54–60 (2010). https://doi.org/10.1007/s11655-010-0054-7

Guo-qiang Yuan, Zhen-hua Jia, Hai-tao Yang, et al. Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction. [J]. Chinese Journal of Integrative Medicine 16(1):54-60(2010)
Yuan, Gq., Jia, Zh., Yang, Ht. et al. Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction., Chin. J. Integr. Med. 16, 54–60 (2010). https://doi.org/10.1007/s11655-010-0054-7 DOI：

Guo-qiang Yuan, Zhen-hua Jia, Hai-tao Yang, et al. Comfortable lifestyle-induced imbalance of neuro-endocrineimmunity network: A possible mechanism of vascular endothelial dysfunction. [J]. Chinese Journal of Integrative Medicine 16(1):54-60(2010) DOI： 10.1007/s11655-010-0054-7.

摘要

To observe the changes of vascular endothelial functions and general neuro-endocrine-immunity (NEI) network under the state of qi-deficiency syndrome induced by excessive idleness and to approach their internal relevance and illuminate initially the pathophysiological mechanism of vascular lesion induced by excessive idleness. A total of 100 male Wistar rats were randomly divided into the control group and the qi-deficiency syndrome model group

50 rats in each group. The qi-deficiency syndrome model was established by feeding the animals with hyper-alimentation diet in combination with restricting movement for 10 weeks. Changes of common chemical signal molecules related to NEI and vascular endothelial functions were measured by the end of the experiment. Furthermore

their internal relevance was analyzed by the method of canonical correlation analysis. The vascular endothelial structure and function were obviously injured in the model group. Compared with the control group

the chemical signal molecules

such as 5-hydroxytryptamine (5-HT)

corticosterone (CORT)

triiodothyronine (T3)

tetraiodothyronine (T4)

angiotensin II (Ang II)

interleukin-1 (IL-1)

and tumor necrosis factor-α (TNF-α) in peripheral blood of the model group (n=43) were changed significantly (P<0.05 or P<0.01). Canonical correlation analysis showed that vascular endothelial dysfunction was correlated to the changes of these signal molecules in the NEI network. Comfort-based lifestyle induced not only vascular endothelial dysfunction but also an imbalance of the NEI network. Vascular endothelial dysfunction and the imbalanced NEI network interacted with each other

and an imbalance of the NEI network may be the pathophysiologic basis for the genesis and development of vascular endothelial dysfunction

even diseases of the blood vessel.

Abstract

the chemical signal molecules

such as 5-hydroxytryptamine (5-HT)

corticosterone (CORT)

triiodothyronine (T3)

tetraiodothyronine (T4)

angiotensin II (Ang II)

interleukin-1 (IL-1)

and an imbalance of the NEI network may be the pathophysiologic basis for the genesis and development of vascular endothelial dysfunction

even diseases of the blood vessel.

关键词

qi-deficiency syndromevascular endothelial functionneuro-endocrine-immunity networkchemical signal molecules

Keywords

qi-deficiency syndromevascular endothelial functionneuro-endocrine-immunity networkchemical signal molecules

references

Besedovsky HO, Del Rey A. Immune-neuro-endocrine interaction: facts and hypotheses. Endocr Rev 1996;17:64–102.

Xia Q. Review of regulation of cardiovascular functions. J Zhejiang Univ (Med Sci, Chin) 2003; 32:171–174.

Deng JY, Shi D. Progress on the research of the immunological mechanism of vascular endothelial cell injury. Chin J Gen Surg (Chin) 2003;12:462–464.

Chen Y, Wang Y, Li Y, Sun SZ, Yu YH, Wang YL, et al. Effects of different interventional modalities on vascular endothelial dysfunction of obese rats. Chin J Pediatr (Chin) 2006;44:607–610.

Li JL, Fang ZQ. Review of animal model preparative method of syndrome of qi-deficiency. Acta Univ Tradit Med Sicensis Pharmacol Shanghai (Chin) 2004;18(3):56–60.

Ding FL, Liu C. The changes of markers to endothelium cell injury in patients with type 2 diabetes. Clin Med (Chin) 2006; 26(12):81–82.

Kroeze WK, Kristiansen K, Roth BL. Molecular biology of serotonin receptors structure and function at the molecular level. Curr Top Med Chem 2002;2:507–528.

Wen ZJ, Luo Y. The research progress of 5-HT2 receptor antagonist effect on blood vascular system. Chin J Intern Med (Chin) 2004;43:314–315.

Van der Kolk BA. The psychobiology and psychophamacology of PTSD. Human Psychopharmacol 2001;16:S49–S64.

Hageman I, Andersen HS, Jorgensen MB. Posttraumatic stress disorder: a review of psychobiology and pharmacotherapy. Acta Psychiatr Scand 2001;104:411–422.

Zhang T, Du LP, Cui P, Jiang H. Effect of intimal lesion and glucocorticoid on gene expression of angiotensin II type 1 receptor. J Cardiovas Pulmonary Dis (Chin) 1999;18:9–12.

Gillis S, Ferm MM, Ou W, Smith KA. T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol 1978;120:2027–2032.

Lekakis J, Papamichael C, Alevizaki M, Piperingos G, Marafelis P, Mantzos J, et al. Flow-mediated, endothelium-dependent vasodilation is impaired in subjects with hypothyroidism, borderline hypothyroidism and high-normal serum thyrotropin (TSH) values. Thyroid 1997; 7:411–414.

Taddei S, Caraccio N, Virdis A, Dardano A, Versari D, Ghiadoni L, et al. Impaired endothelium-dependent vasodilation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J Clin Endocrinol Metab 2003; 88:3731–3737.

Fekder C, Arias P, Refojo D, Nacht S, Mohuilevsky J. Interleukin-1 inhibits NMDA-stimulated GnRH secretion: associated effects on the release of hypothalamic inhibitory amino acid neurotransmitters. Neuroimmunomodulation 2000;7:46–50.

Besedovsky HO, Rey AD, Sorkin E, Dinarello CA. Immunoregulation feedback between interleukin-1 and glucocorticoid hormones. Science 1986;233:652–654.

Wang J, Ren JL, Wei JD. The progress of interleukin and cardiovascular disease. Med Recapitulate (Chin) 2002; 8:699–701.

Wang JR, Li N, Wang RG, Wang JK. Progress of interleukin and ischemic cerebrovascular disease. Foreign Med Sci (Neurol Neurosurg, Chin) 1997; 24:59–62.

Taheri SA, Lazar FL, Haddad G, Castaldo R, Wilson M, Mousa S. Diagnosis of deep venous thrombosis by use of soluble necrosis factor receptor. Angiology 1998; 49:537–544.

Esmon CT. Crosstalk between inflammation and thrombosis. Maturitas 2004;47:305–314.

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